CTLA-4 (extracellular domain) scaffold protein anti-Human CD80

Name: CTLA-4 (extracellular domain) scaffold protein anti-Human CD80
SKU: SCT-L065
Rating: 5 (1 reviews)

CAT#: SCT-L065

The CTLA-4 (extracellular domain) that bound CD80 was isolated from the library using Phage display techonology. After affinity maturation, CTLA-4 variants were identified having affinities for CD80 as determined by biosensor technology. It's potential to be used in diagnostic, research and therapeutic applications.

Gene Expression

Normal Tissue Figure 1 Bone marrow

Hematopoietic cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/25368/56116_B_6_4.jpg

Normal Tissue Figure 2 Lymph node

Germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/25368/56076_A_9_8.jpg

RNA Expression Figure 3 RNA cell line category: Cell line enhanced (Daudi, HDLM-2, Karpas-707, U-266/70)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000121594-CD80

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Specifications

Scaffold Name
CTLA-4 (extracellular domain)

Origin
CTLA-4

Core Structure
V-like Ig β-strands

Variable Regions
1–2 loops

Target
CD80

Species Reactivity
Human

Expression Host
E. coli

Applications
ELISA; IHC; Microscopy; FC; WB; FuncS

Target

Alternative Names
CTLA-4; CTLA-4 (extracellular domain); CD80; CD80 molecule; B7; BB1; B7-1; B7.1; LAB7; CD28LG; CD28LG1; T-lymphocyte activation antigen CD80; activation B7-1 antigen; costimulatory factor CD80; CTLA-4 counter-receptor B7.1; B-lymphocyte activation antigen B7; costimulatory molecule variant IgV-CD80; CD80 antigen (CD28 antigen ligand 1, B7-1 antigen); Hodgkin's lymphoma; lymphoma

Gene ID
941

UniProt ID
P01589

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Related Diseases

Rheumatoid Arthritis

Systemic Lupus Erythematosus

Allograft Rejection

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Maturity Onset Diabetes of the Young

Downloadable Resources

Download resources about recombinant antibody development and antibody engineering to boost your research.

Datasheet

Datasheet - SCT-L065.pdf

MSDS

MSDS - SCT-L065.pdf

COA

Certificate of Analysis Lookup

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