Mouse Anti-CD274 Recombinant Antibody Hexamer (VS-0924-YC110), CDC Enhanced (CAT#: VS-0924-YC110)
The product is a hexameric mouse anti-CD274 antibody with enhanced complement-dependent cytotoxicity (CDC) activity. This hexameric IgG1 targets human CD274 and includes hexamerization-enhancing mutations that promote hexamer formation, thereby facilitating optimal C1q binding and boosting CDC.
Specific Inquiry
Subcellular Location and Protein Expression
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line U-251 MG
(Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/3528/1899_B9_6_cr5ba2049576272_selected.jpg
(Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/3528/1899_B9_6_cr5ba2049576272_selected.jpg
Figure 2 IF staining of human cell line BJ
(Immunofluorescent staining of human cell line BJ shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/3528/1936_G3_3_blue_red_green.jpg
(Immunofluorescent staining of human cell line BJ shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/3528/1936_G3_3_blue_red_green.jpg
Figure 3 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/3528/1953_G5_3_blue_red_green.jpg
(Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/3528/1953_G5_3_blue_red_green.jpg
Figure 4 Colon
(Peripheral nerve/ganglion
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/76385/169546_A_9_3.jpg
(Peripheral nerve/ganglion
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/76385/169546_A_9_3.jpg
Figure 5 Placenta
(Cytotrophoblasts
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Syncytiotrophoblasts - cell body
Staining:Medium
Intensity: Moderate
Quantity:>75%
Syncytiotrophoblasts - microvilli
Staining:High
Intensity: Strong)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/76385/169546_A_1_7.jpg
(Cytotrophoblasts
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Syncytiotrophoblasts - cell body
Staining:Medium
Intensity: Moderate
Quantity:>75%
Syncytiotrophoblasts - microvilli
Staining:High
Intensity: Strong)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/76385/169546_A_1_7.jpg
Figure 6 RNA cell line category: Cell line enhanced (HDLM-2, HHSteC, U-251 MG)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000120217-CD274
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000120217-CD274
Specifications
- Host Species
- Mouse
- Type
- Antibody hexamer
- Specificity
- Human CD274
- Species Reactivity
- Human
- Molecule Class
- ~ 900 kDa
- Applications
- ELISA, WB, SPR, ADCC, CDC
- Conjugate
- None
- Related Disease
- Cancer, infectious diseases, pathological disorders
Product Property
- Clonality
- Monoclonal
- Purification
- Protein G purified
- Purity
- >95% determined as SDS-PAGE and SEC-HPLC
- Aggregation
- <5%
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- Store at 4°C short term (1-2 weeks). Store at -20°C long term (12 months). Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- CD274; CD274 molecule; B7-H; B7H1; PDL1; PD-L1; PDCD1L1; PDCD1LG1; programmed cell death 1 ligand 1; B7 homolog 1; CD274 antigen; PDCD1 ligand 1; programmed death ligand 1
- Gene ID
- 29126
- UniProt ID
- Q0GN75
- Long Name
- CD274 Molecule
Downloads
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ScFv-Fc Chimera Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NAB-305-sdAb | Recombinant Anti-Mouse Cd274 VHH Single Domain Antibody | IHC, IP, FC, Neut, FUNC | Llama VHH |
| HPAB-N0408-YC-VHH | Recombinant Humanized Anti-CD274 Single Domain Antibody (HPAB-N0408-YC-VHH) | ELISA, FC, BL | Human VHH |
| HPAB-N0307-YC-VHH | Recombinant Humanized Anti-CD274 Single Domain Antibody (HPAB-N0307-YC-VHH) | ELISA, FC, BL | Humanized VHH |
| NBD-0065-YJ-VHH | Camelid Anti-CD274 Recombinant Single Domain Antibody (NBD-0065-YJ-VHH) | ELISA | Camelid VHH |
| NBD-0066-YJ-VHH | Camelid Anti-CD274 Recombinant Single Domain Antibody (NBD-0066-YJ-VHH) | ELISA, Inihb | Camelid VHH |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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