Recombinant Anti-CD274 Biparatopic Antibody, Tandem scFv (CAT#: VS-0525-YC202)

• Host Animal 1
• Human

• Host Animal 2
• Human

• Specificity
• Human CD274

• Species Reactivity
• Human

• Type
• Tandem scFv

• Valency
• 1 + 1

• Epitope 1
• The epitope 1 is constituted by the C strand, F strand, G strand, CC' loop, and N-terminal region of PD-L1.

• Epitope 2
• The epitope 2 is formed by the CC'FG antiparallel β-sheet and the BC, CC', C'C″, and FG loops

• Purity
• >90%

• Purification
• Affinity purified

• Applications
• ELISA, IHC, FC, IP, IF

• Concentration
• Lot specific

• Buffer
• PBS, pH 7.4

• Preservative
• No preservatives

• Storage
• Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid freeze-thaw cycles.

• Long Name
• CD274 Molecule

• Introduction
• This gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human malignancies, including colon cancer and renal cell carcinoma. Alternative splicing results in multiple transcript variants.

• Alternative Names
• Programmed cell death 1 ligand 1; B7H1; B7-H1; PDL1; PD-L1; PDCD1L1; B7 homolog 1; B7 homologue 1

• Gene ID
• 29126

• UniProt ID
• Q9NZQ7

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