Recombinant Anti-CD274 Vesicular Antibody, EV Displayed (VS-0425-YC608) (CAT#: VS-0425-YC608)

• Application
• Block, ELISA, FC, Cell-uptake

• Product Type
• Ab-Fc-EVs

• Antibody Quantification (Ab/EV)
• ~100 Ab/EV

• Target
• CD274

• Host Animal
• Human

• Antibody Isotype
• IgG

• Species Reactivity
• Human, Cynomolgus, Mouse

• Expression Cell
• Mammalian cell

• EV-sorting domain
• CD63

• Fc-binding domain
• z domain

• EV Size
• 30~150 nm

• Producing Cell
• HEK293F

• Isolation Method
• Gradient centrifugation

• Purification
• qEV size exclusion chromatography

• Binding Affinity
• Kd = 0.85 µg/mL

• Concentration
• 1 x 10¹⁰

• Size
• 1 mL

• Buffer
• PBS

• Storage
• Store at -80°C for 12 months

• Full Name
• CD274 molecule

• Biological Process
• Adaptive immunity, Immunity

• Molecular Function
• Receptor

• Cellular Localization
• Plasma membrane, Actin filaments, Nucleoplasm

• Introduction
• This gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human malignancies, including colon cancer and renal cell carcinoma.

• Alternative Names
• B7-H, B7-H1, B7H1, PD-L1, PDCD1LG1, PDL1

• Gene ID
• 29126

• UniProt ID
• Q9NZQ7

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