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    Recombinant Anti-CD274 Vesicular Antibody, EV Displayed (VS-0425-YC608)

    CAT#: VS-0425-YC608

    The Recombinant Anti-CD274 Vesicular Antibody, EV Displayed (VS-0425-YC608) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to CD274-expressed cells or tissues. CD274 is an immune inhibitory receptor ligand interacting with its receptor to inhibit T-cell activation. This interaction prevents autoimmunity but enables tumor immune escape.

    Gene Expression
    ❮
    Figure 1 IF staining of human cell line U-251 MG Figure 2 IF staining of human cell line BJ Figure 3 IF staining of human cell line U-2 OS Figure 4 Colon Figure 5 Placenta Figure 6 RNA cell line category: Cell line enhanced (HDLM-2, HHSteC, U-251 MG)
    ❯

    Recombinant Antibody

    • Application
    • Block, ELISA, FC, Cell-uptake
    • Product Type
    • Ab-Fc-EVs
    • Antibody Quantification (Ab/EV)
    • ~100 Ab/EV
    • Target
    • CD274
    • Host Animal
    • Human
    • Antibody Isotype
    • IgG
    • Species Reactivity
    • Human, Cynomolgus, Mouse
    • Expression Cell
    • Mammalian cell

    Engineered EVs

    • EV-sorting domain
    • CD63
    • Fc-binding domain
    • z domain
    • EV Size
    • 30~150 nm
    • Producing Cell
    • HEK293F
    • Isolation Method
    • Gradient centrifugation
    • Purification
    • qEV size exclusion chromatography
    • Binding Affinity
    • Kd = 0.85 µg/mL
    • Concentration
    • 1 x 10¹⁰
    • Size
    • 1 mL
    • Buffer
    • PBS
    • Storage
    • Store at -80°C for 12 months

    Target

    • Full Name
    • CD274 molecule
    • Biological Process
    • Adaptive immunity, Immunity
    • Molecular Function
    • Receptor
    • Cellular Localization
    • Plasma membrane, Actin filaments, Nucleoplasm
    • Introduction
    • This gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human malignancies, including colon cancer and renal cell carcinoma.
    • Alternative Names
    • B7-H, B7-H1, B7H1, PD-L1, PDCD1LG1, PDL1
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    Datasheet

    Datasheet - VS-0425-YC608.pdf

    MSDS

    MSDS - VS-0425-YC608.pdf

    COA

    Certificate of Analysis Lookup

    To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.

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