Afuco™ Anti-CD274 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-417CQ)

Name: Afuco™ Anti-CD274 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-417CQ)
SKU: AFC-TAB-417CQ
Rating: 5 (1 reviews)

CAT#: AFC-TAB-417CQ

This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant monoclonal antibody to CD274. It is a human monoclonal antibody that can be potentially used in the treatment of Cancers, non-small cell lung (NSCLC), Solid tumors, bladder, urothelial.

Gene Expression

Subcellular Location and Protein Expression Figure 1 IF staining of human cell line U-251 MG

Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/3528/1899_B9_6_cr5ba2049576272_selected.jpg

Subcellular Location and Protein Expression Figure 2 IF staining of human cell line BJ

Immunofluorescent staining of human cell line BJ shows localization to plasma membrane.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/3528/1936_G3_3_blue_red_green.jpg

Subcellular Location and Protein Expression Figure 3 IF staining of human cell line U-2 OS

Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/3528/1953_G5_3_blue_red_green.jpg

Normal Tissue Figure 4 Colon

Peripheral nerve/ganglion
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/76385/169546_A_9_3.jpg

Normal Tissue Figure 5 Placenta

Cytotrophoblasts
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Syncytiotrophoblasts - cell body
Staining:Medium
Intensity: Moderate
Quantity:>75%
Syncytiotrophoblasts - microvilli
Staining:High
Intensity: Strong

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/76385/169546_A_1_7.jpg

RNA Expression Figure 6 RNA cell line category: Cell line enhanced (HDLM-2, HHSteC, U-251 MG)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000120217-CD274

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Specifications

Immunogen
The details of the immunogen for this antibody are not available.

Host Species
Human

Derivation
Human

Type
ADCC enhanced antibody

Specificity
Human CD274

Species Reactivity
Human

Applications
ELISA, IHC, FC, IP, IF, Inhib

Conjugate
Unconjugated

Trade name
Imfinzi

Generic Name
Durvalumab

Related Disease
Cancers, non-small cell lung (NSCLC), Solid tumors, bladder, urothelial

Product Property

Purity
>95% by SDS-PAGE

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Alternative Names
Programmed cell death 1 ligand 1; B7H1; B7-H1; PDL1; PD-L1; PDCD1L1; B7 homolog 1; B7 homologue 1

Gene ID
29126

UniProt ID
Q9NZQ7

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Biosimilar Overview

Please refer to Durvalumab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Durvalumab.

Downloadable Resources

Download resources about recombinant antibody development and antibody engineering to boost your research.

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

Datasheet - AFC-TAB-417CQ.pdf

MSDS

MSDS - AFC-TAB-417CQ.pdf

COA

Certificate of Analysis Lookup

To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.

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Protocol & Troubleshooting

Immunofluorescence (IF)

Immunohistochemistry (IHC)

We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.

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DrugMonitor™ Anti-Durvalumab Antibody (VS-1224-YC381)
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See other products for "Cd274"

Select a product category from the dropdown menu below to view related products.

CAT	Product Name	Application	Type
TAB-0190CL	Anti-Human CD274 Recombinant Antibody (PD1-AB1)	FC, ELISA, FuncS
TAB-0997CL	Anti-Human CD274 Recombinant Antibody (B60-55)	ELISA, FuncS, FC, PK	Human antibody
TAB-0190CL-F(E)	Anti-Human CD274 Recombinant Antibody Fab Fragment (PD1-AB1)	FC, ELISA, FuncS
TAB-0997CL-F(E)	Anti-Human CD274 Recombinant Antibody Fab Fragment (B60-55)	ELISA	Human antibody
TAB-1002CL-F(E)	Mouse Anti-CD274 Recombinant Antibody (TAB-1002CL-F(E)); Fab Fragment	ELISA, FC	Mouse Fab

CAT	Product Name	Application	Type
TAB-0263CL	Human Anti-CD274 Recombinant Antibody (TAB-0263CL)	ELISA, WB, SPR, FuncS	Humanized IgG
TAB-0264CL	Human Anti-CD274 Recombinant Antibody (TAB-0264CL)	ELISA, WB, SPR, ADCC, CDC, FuncS, Inhib	Humanized IgG
TAB-0265CL	Human Anti-CD274 Recombinant Antibody (TAB-0265CL)	ELISA, WB, SPR, ADCC, CDC, FuncS	Humanized IgG
TAB-0266CL	Human Anti-CD274 Recombinant Antibody (TAB-0266CL)	ELISA, WB, SPR, ADCC, CDC, FuncS	Humanized IgG
TAB-0267CL	Human Anti-CD274 Recombinant Antibody (TAB-0267CL)	ELISA, WB, SPR, ADCC, CDC, FuncS	Humanized IgG

CAT	Product Name	Application	Type
TAB-0992CL	Mouse Anti-CD274 Recombinant Antibody (TAB-0992CL)	Inhib, FC, SPR	Mouse IgG
TAB-0993CL	Mouse Anti-CD274 Recombinant Antibody (TAB-0993CL)	FC, SPR	Mouse IgG
TAB-0994CL	Mouse Anti-CD274 Recombinant Antibody (TAB-0994CL)	ELISA, FC	Mouse IgG
TAB-1009CL	Mouse Anti-CD274 Recombinant Antibody (TAB-1009CL)	WB, IHC	Mouse IgG1, κ
TAB-1010CL	Anti-Human CD274 Recombinant Antibody	FC

CAT	Product Name	Application	Type
TAB-0995CL	Human Anti-CD274 Recombinant Antibody (TAB-0995CL)	ELISA, FC	Chimeric (Mouse/Human) IgG1, κ
TAB-0995CL-S(P)	Human Anti-CD274 Recombinant Antibody; scFv Fragment (TAB-0995CL-S(P))	ELISA, FC	Human scFv
TAB-0995CL-F(E)	Human Anti-CD274 Recombinant Antibody; Fab Fragment (TAB-0995CL-F(E))	ELISA, FC	Chimeric (Mouse/Human) Fab

CAT	Product Name	Application	Type
NEUT-324CQ	Mouse Anti-CD274 Recombinant Antibody (clone 29E.2A3.C6)	IHC-P, FC, Neut, ICC	Mouse IgG2b, κ
NEUT-325CQ	Human Anti-CD274 Recombinant Antibody (clone CBLS-206)	Neut	Human IgG1, κ
NEUT-326CQ	Human Anti-CD274 Recombinant Antibody (clone CBLS-207)	ELISA, Neut	Human IgG1, κ
NEUT-327CQ	Mouse Anti-CD274 Recombinant Antibody (clone MIH1)	FC, FuncS, Neut, IHC, IF	Mouse IgG1, κ
NEUT-330CQ	Rat Anti-CD274 Recombinant Antibody (clone MIH5)	FC, FuncS, Neut, IHC-Fr, WB	Rat IgG2a, λ

CAT	Product Name	Application	Type
NEUT-328CQ	Rat Anti-CD274 Recombinant Antibody (VMC171)	Block, FC	Rat IgG2
NEUT-329CQ	Rat Anti-CD274 Recombinant Antibody (clone 10F.9G2)	FC, IF, Block	Rat IgG2b, κ
NEUT-331CQ	Mouse Anti-CD274 Recombinant Antibody (clone alphaPD-L1)	ELISA, Block	Mouse IgG1, λ
NEUT-332CQ	Rabbit Anti-CD274 Recombinant Antibody (clone CBL1009)	Block	Rabbit IgG

CAT	Product Name	Application	Type
MOR-0548	Hi-Affi™ Rabbit Anti-CD274 Recombinant Antibody (clone DS548AB)	ELISA	Rabbit IgG
MOR-4049	Hi-Affi™ Rabbit Anti-CD274 Recombinant Antibody (clone SI116DS)	ELISA	Rabbit IgG
MOR-4050	Hi-Affi™ Rabbit Anti-CD274 Recombinant Antibody (clone SI117DS)	ICC, IF, FC	Rabbit IgG
MOR-4051	Hi-Affi™ Rabbit Anti-CD274 Recombinant Antibody (clone SI118DS)	FC	Rabbit IgG

CAT	Product Name	Application	Type
HPAB-N0326-YC-S(P)	Human Anti-CD274 Recombinant Antibody; scFv Fragment (HPAB-N0326-YC-S(P))	ELISA, FuncS	Human scFv
HPAB-0933LY-S(P)	Human Anti-CD274 Recombinant Antibody; scFv Fragment (HPAB-0933LY-S(P))	Inhib, ELISA	Human scfv
HPAB-0934LY-S(P)	Human Anti-CD274 Recombinant Antibody; scFv Fragment (HPAB-0934LY-S(P))	Inhib, ELISA	Human scfv
HPAB-0935LY-S(P)	Human Anti-CD274 Recombinant Antibody; scFv Fragment (HPAB-0935LY-S(P))	Inhib, ELISA	Human scfv
HPAB-0936LY-S(P)	Human Anti-CD274 Recombinant Antibody; scFv Fragment (HPAB-0936LY-S(P))	Inhib, ELISA	Human scfv

CAT	Product Name	Application	Type
HPAB-0400LY	Human Anti-PDCD1 Recombinant Antibody (HPAB-0400LY)	ELISA, RIA, WB	Human IgG1
HPAB-0401LY	Human Anti-PDCD1 Recombinant Antibody (HPAB-0401LY)	ELISA, RIA, WB	Human IgG1
HPAB-0402LY	Human Anti-PDCD1 Recombinant Antibody (HPAB-0402LY)	ELISA, RIA, WB	Human IgG1
HPAB-0403LY	Human Anti-PDCD1 Recombinant Antibody (HPAB-0403LY)	ELISA, RIA, WB	Human IgG1
HPAB-0404LY	Human Anti-CD274 Recombinant Antibody (HPAB-0404LY)	ELISA, RIA, WB	Human IgG1

CAT	Product Name	Application	Type
HPAB-0933LY-F(E)	Human Anti-CD274 Recombinant Antibody; Fab Fragment (HPAB-0933LY-F(E))	Inhib, ELISA	Human Fab
HPAB-0934LY-F(E)	Human Anti-CD274 Recombinant Antibody; Fab Fragment (HPAB-0934LY-F(E))	Inhib, ELISA	Human Fab
HPAB-0935LY-F(E)	Human Anti-CD274 Recombinant Antibody; Fab Fragment (HPAB-0935LY-F(E))	Inhib, ELISA	Human Fab
HPAB-0936LY-F(E)	Human Anti-CD274 Recombinant Antibody; Fab Fragment (HPAB-0936LY-F(E))	Inhib, ELISA	Human Fab
HPAB-0937LY-F(E)	Human Anti-CD274 Recombinant Antibody; Fab Fragment (HPAB-0937LY-F(E))	Inhib, ELISA	Human Fab

CAT	Product Name	Application	Type
AFC-TAB-418CQ	Afuco™ Anti-CD274 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-418CQ)	ELISA, IHC, FC, IP, IF, BL	ADCC enhanced antibody

CAT	Product Name	Application	Type
NBD-0065-YJ-VHH	Camelid Anti-CD274 Recombinant Single Domain Antibody (NBD-0065-YJ-VHH)	ELISA	Camelid VHH
NBD-0066-YJ-VHH	Camelid Anti-CD274 Recombinant Single Domain Antibody (NBD-0066-YJ-VHH)	ELISA, Inihb	Camelid VHH
NBD-0067-YJ-VHH	Camelid Anti-CD274 Recombinant Single Domain Antibody (NBD-0067-YJ-VHH)	ELISA, FC	Camelid VHH
NBD-0068-YJ-VHH	Camelid Anti-CD274 Recombinant Single Domain Antibody (NBD-0068-YJ-VHH)	ELISA, FC	Camelid VHH
NBD-0069-YJ-VHH	Camelid Anti-CD274 Recombinant Single Domain Antibody (NBD-0069-YJ-VHH)	ELISA, FC	Camelid VHH

CAT	Product Name	Application	Type
VS-0924-YC110	Mouse Anti-CD274 Recombinant Antibody Hexamer (VS-0924-YC110), CDC Enhanced	ELISA, WB, SPR, ADCC, CDC	Antibody hexamer
VS-0924-YC111	Human Anti-CD274 Recombinant Antibody Hexamer (VS-0924-YC111), CDC Enhanced	ELISA, WB, SPR, ADCC, CDC, Inhib	Antibody hexamer

CAT	Product Name	Application	Type
VS-1024-XY375	Mouse Anti-NHP CD274 Recombinant Antibody (clone 29E.2A3)	FC	Mouse IgG2b, kappa

CAT	Product Name	Application	Type
VS-0225-XY32	CytoStream™ Mouse Anti-CD274 Recombinant Antibody (clone 29E.2A3)	FC	Mouse IgG2b, kappa

CAT	Product Name	Application	Type
VS-0325-FY65	Human Anti-CD274 (clone MI4736) scFv-Fc Chimera	ELISA, Inhib	Human IgG1, scFv-Fc

CAT	Product Name	Application	Type
VS-0425-YC608	Recombinant Anti-CD274 Vesicular Antibody, EV Displayed (VS-0425-YC608)	Block, ELISA, FC, Cell-uptake

CAT	Product Name	Application
VS-0525-XY1152	Anti-CD274 Immunohistochemistry Kit	IHC
VS-0525-XY1153	Anti-Mouse CD274 Immunohistochemistry Kit	IHC
VS-0525-XY1154	Anti-Human CD274 Immunohistochemistry Kit	IHC

CAT	Product Name	Application	Type
VS-0525-YC202	Recombinant Anti-CD274 Biparatopic Antibody, Tandem scFv	ELISA, IHC, FC, IP, IF	Tandem scFv

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