Anti-CD44 (clone RG7356) Recombinant Antibody Coupled Liposome (VS-1024-FY41)
CAT#: VS-1024-FY41
Anti-CD44 antibody liposomes are specialized nanocarriers that utilize liposomal technology to deliver therapeutic agents directly to CD44-expressing cells, such as certain cancer cells and immune cells. CD44 is a cell surface glycoprotein involved in cell-cell interactions, cell migration, and the retention of hyaluronic acid in tissues. It is often overexpressed in various tumors and plays a significant role in cancer progression, metastasis, and inflammation.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane & the Golgi apparatus.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/316/203_H10_1_selected.jpg
Subcellular Location
Figure 2 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/112/if_selected.jpg
Subcellular Location
Figure 3 IHC staining of human vagina
Immunohistochemical staining of human vagina shows strong cytoplasmic positivity in squamous epithelial cells.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/316/5_B_2_2_selected.jpg
Normal Tissue
Figure 4 Colon
Endocrine cells
Staining: High
Intensity: Strong
Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Enterocytes
Staining: Medium
Intensity: Strong
Quantity: <25%
Goblet cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Mucosal lymphoid cells
Staining: High
Intensity: Strong
Quantity:>75%
Peripheral nerve/ganglion
Staining: High
Intensity: Strong
Quantity: 75%-25%
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/5785/16384_A_9_3.jpg
Normal Tissue
Figure 5 Kidney
Cells in glomeruli
Staining: Medium
Intensity: Strong
Quantity: <25%
Distal tubules
Staining: Medium
Intensity: Strong
Quantity: <25%
Proximal tubules (cell body)
Staining: Medium
Intensity: Strong
Quantity: <25%
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/5785/16384_A_8_5.jpg
Normal Tissue
Figure 6 Skin
Cells in basal layer
Staining: High
Intensity: Strong
Quantity:>75%
Cells in spinous layer
Staining: High
Intensity: Strong
Quantity:>75%
Fibrohistiocytic cells
Staining: High
Intensity: Strong
Langerhans cells
Staining: High
Intensity: Strong
Quantity:>75%
Lymphocytes
Staining: High
Intensity: Strong
Melanocytes
Staining: High
Intensity: Strong
Quantity:>75%
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/5785/16384_B_7_1.jpg
Normal Tissue
Figure 7 Lymph node
Germinal center cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/5785/16384_A_7_8.jpg
RNA Expression
Figure 8 RNA cell line category: Cell line enhanced (hTERT-RPE1)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000026508-CD44
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More Infomation
Specifications
- Potential Clinical Applications
- Colon, breast, pancreas, and head and neck cancer
Product Composition
- Clone
- RG7356
- Antibody Type
- IgG1, kappa
- Antibody Host
- Humanized
- Antibody Reactivity
- Human
- Antibody Description
- This is a humanized antibody that specifically targets CD44 and demonstrates antitumor activity in mice with tumors expressing CD44, such as those implanted with MDA-MB-231 breast cancer cells. In a short-term treatment regimen, tumor-bearing mice exhibited changes in the MAPK pathway in the responsive model; however, no alterations were detected in downstream phosphorylation in a nonresponsive xenograft model.
Product Property
- Storage
- See in the COA
- Storage Shelf Time
- See in the COA
Target Information
- Target
- CD44
- Alternative Names
- CD44 Molecule (Indian Blood Group); Hematopoietic Cell E- And L-Selectin Ligand; GP90 Lymphocyte Homing/Adhesion Receptor; Chondroitin Sulfate Proteoglycan 8; Extracellular Matrix Receptor III; Heparan Sulfate Proteoglycan; Phagocytic Glycoprotein 1; Hyaluronate Receptor; Hermes Antigen; CD44 Antigen; ECMR-III; HUTCH-I; Epican; CDW44; MDU2; MDU3
- Full Name
- CD44 Molecule (Indian Blood Group)
- Gene ID
- 960
- UniProt ID
- P16070
- Cellular Localization
- Cell membrane, Cell projection, Membrane
- Post Translation Modifications
- Proteolytically cleaved in the extracellular matrix by specific proteinases (possibly MMPs) in several cell lines and tumors.
N-glycosylated.
O-glycosylated. O-glycosylation contains more-or-less-sulfated chondroitin sulfate glycans, whose number may affect the accessibility of specific proteinases to their cleavage site(s). It is uncertain if O-glycosylation occurs on Thr-637 or Thr-638.
Phosphorylated; activation of PKC results in the dephosphorylation of Ser-706 (constitutive phosphorylation site), and the phosphorylation of Ser-672.
- Protein Refseq
- NP_000601.3; NP_001001389.1; NP_001001390.1
- Function
- Cell-surface receptor that plays a role in cell-cell interactions, cell adhesion and migration, helping them to sense and respond to changes in the tissue microenvironment (PubMed:16541107, PubMed:19703720, PubMed:22726066).
Participates thereby in a wide variety of cellular functions including the activation, recirculation and homing of T-lymphocytes, hematopoiesis, inflammation and response to bacterial infection (PubMed:7528188).
Engages, through its ectodomain, extracellular matrix components such as hyaluronan/HA, collagen, growth factors, cytokines or proteases and serves as a platform for signal transduction by assembling, via its cytoplasmic domain, protein complexes containing receptor kinases and membrane proteases (PubMed:18757307, PubMed:23589287).
Such effectors include PKN2, the RhoGTPases RAC1 and RHOA, Rho-kinases and phospholipase C that coordinate signaling pathways promoting calcium mobilization and actin-mediated cytoskeleton reorganization essential for cell migration and adhesion (PubMed:15123640).
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Datasheet
MSDS
COA
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| TAB-231LC-S(P) | Mouse Anti-CD44 Recombinant Antibody; scFv Fragment (TAB-231LC-S(P)) | ELISA | Mouse scFv |
| TAB-232LC-S(P) | Mouse Anti-CD44 Recombinant Antibody; scFv Fragment (TAB-232LC-S(P)) | ELISA | Mouse scFv |
| TAB-235LC-S(P) | Anti-Human CD44 Recombinant Antibody scFv Fragment (chPTA-4621) | FC | Chimeric antibody (mouse/human) |
| TAB-231LC-F(E) | Human Anti-CD44 Recombinant Antibody; Fab Fragment (TAB-231LC-F(E)) | ELISA | Chimeric (mouse/human) Fab |
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| HPAB-N0328-YC | Rat Anti-CD44 Recombinant Antibody (clone 9A4) | WB, ELISA, IHC-P, IHC-Fr | Rat IgG1 |
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| CAT | Product Name | Application | Type |
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| NEUT-379CQ | Mouse Anti-CD44 Recombinant Antibody (clone F10-44-2) | WB, Neut, FC, IHC, IHC-Fr, IHC-P, IP, ICC | Mouse IgG2a |
| NEUT-380CQ | Rat Anti-CD44 Recombinant Antibody (clone Hermes-1) | WB, Neut, ELISA, FC, IF, IHC, IP | Rat IgG2a |
| CAT | Product Name | Application | Type |
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|---|---|---|---|
| HPAB-0054-YC-S(P) | Mouse Anti-CD44 Recombinant Antibody (clone mH460-16-2); scFv Fragment | ELISA, FC, IHC | Mouse scFv |
| HPAB-0047-YJ-S(P) | Mouse Anti-CD44 Recombinant Antibody (clone HI44a); scFv Fragment | WB, IF, FC | Mouse scFv |
| HPAB-0746-FY-F(E) | Human Anti-CD44 Recombinant Antibody; Fab Fragment (HPAB-0746-FY-F(E)) | ELISA | Human Fab |
| HPAB-0747-FY-F(E) | Human Anti-CD44 Recombinant Antibody; Fab Fragment (HPAB-0747-FY-F(E)) | ELISA | Human Fab |
| HPAB-0443-YJ-S(P) | Human Anti-CD44 Recombinant Antibody (clone CA14); scFv Fragment | ELISA, FuncS | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0019-CN-F(E) | Mouse Anti-CD44 Recombinant Antibody (clone AV6); Fab Fragment | FC | Mouse Fab |
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| HPAB-0747-FY-S(P) | Human Anti-CD44 Recombinant Antibody; scFv Fragment (HPAB-0747-FY-S(P)) | ELISA | Human scFv |
| CAT | Product Name | Application | Type |
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| MRO-0307-CN | Mouse Anti-CD44 Recombinant Antibody (clone A7-1) | WB, IHC, FC | Mouse IgM |
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| AFC-TAB-727 | Afuco™ Anti-CD44 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-727) | ELISA, FC, IP, FuncS, IF, Neut | ADCC enhanced antibody |
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