Mouse Anti-CD70 Recombinant Antibody (clone m1F6) (CAT#: HPAB-AP584-YC)
Provided are recombinant anti-CD70 antibodies, that exert a cytotoxic, cytostatic or immunomodulatory on CD70 expressing cells. The antibody could be used for the prophylaxis or treatment of CD70-expressing cancers and immunological disorders where CD70-expressing cells are present.
Specific Inquiry
ICC
Figure 1 Subcellular localization, microtubule-disrupting, and anti-mitotic activities of 1F6 ADCs.
786-O cells were treated with the indicated mAb, ADCs, or free AFP. Microtubule organization was examined by an anti-a-tubulin antibody and counterstained with AF488-conjugated goat anti-mouse IgG while nuclei were counterstained with DAPI. One to three representative cells from each treatment are shown.
Law, C. L., Gordon, K. A., Toki, B. E., Yamane, A. K., Hering, M. A., Cerveny, C. G., ... & Sauter, G. (2006). Lymphocyte activation antigen CD70 expressed by renal cell carcinoma is a potential therapeutic target for anti-CD70 antibody-drug conjugates. Cancer Research, 66(4), 2328-2337.
FC
Figure 2 Subcellular localization, microtubule-disrupting, and anti-mitotic activities of 1F6 ADCs.
Cell cycle distribution and DNA synthesis in 786-O cells at progressive time points after m1F6, m1F6-vcAFP8, or IgG-vcAFP8 treatment was determined by anti-bromodeoxyuridine and propidium iodide staining and flow cytometry. G0-G1, S, G2-M, and apoptotic events were defined on the dual-color dot plots as described before. Percentages of cells in different phases of the cell cycle were plotted against time after drug treatment.
Law, C. L., Gordon, K. A., Toki, B. E., Yamane, A. K., Hering, M. A., Cerveny, C. G., ... & Sauter, G. (2006). Lymphocyte activation antigen CD70 expressed by renal cell carcinoma is a potential therapeutic target for anti-CD70 antibody-drug conjugates. Cancer Research, 66(4), 2328-2337.
Specifications
- Host Species
- Mouse
- Type
- Mouse IgG
- Specificity
- Human CD70
- Species Reactivity
- Human, Mouse
- Clone
- m1F6
- Applications
- FC, ADCC, CDC, FuncS
- Related Disease
- Cancer
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- The CD70 antibody has been reported in applications of Immunocytochemistry, Flow Cytometry, Functional Assay.
Target
- Alternative Names
- CD70 Molecule; Tumor Necrosis Factor Ligand Superfamily Member 7; CD70 Antigen; CD27 Ligand; CD27LG; TNFSF7; CD27-L
- Gene ID
- 970
- UniProt ID
- P32970
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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Humanized Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-H76 | Anti-Human CD70 Recombinant Antibody (Vorsetuzumab) | ELISA, FC, IP, FuncS, IF, Neut, ICC | IgG1 - kappa |
| TAB-882 | Anti-Human CD70 Recombinant Antibody (Vorsetuzumab Mafodotin) | ELISA, FC, IP, FuncS, IF, Neut, ICC | IgG1 - kappa |
| TAB-342LC-F(E) | Human Anti-CD70 Recombinant Antibody; Fab Fragment (TAB-342LC-F(E)) | FC | Humanized Fab |
| TAB-343LC-F(E) | Human Anti-CD70 Recombinant Antibody; Fab Fragment (TAB-343LC-F(E)) | FC | Humanized Fab |
| TAB-344LC-F(E) | Human Anti-CD70 Recombinant Antibody; Fab Fragment (TAB-344LC-F(E)) | FC | Humanized Fab |
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-336LC-F(E) | Anti-Human CD70 Recombinant Antibody Fab Fragment (Mb VLVH) | FC, ELISA | Human antibody |
| TAB-337LC-F(E) | Anti-Human CD70 Recombinant Antibody Fab Fragment (Mb VHVL) | FC, ELISA | Human antibody |
| TAB-338LC-F(E) | Anti-Human CD70 Recombinant Antibody Fab Fragment (VL-5-VH) | FC, ELISA | Human antibody |
| TAB-339LC-F(E) | Anti-Human CD70 Recombinant Antibody Fab Fragment (VH-5-VL) | FC, ELISA | Human antibody |
| TAB-340LC-F(E) | Anti-Human CD70 Recombinant Antibody Fab Fragment (VL-8-VH) | FC, ELISA | Human antibody |
Neutralizing Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-403CQ | Rat Anti-Cd70 Recombinant Antibody (clone 9G24) | ELISA, Neut | Rat IgG1 |
| NEUT-405CQ | Rat Anti-Cd70 Recombinant Antibody (clone CBL684) | ELISA, Neut | Rat IgG1 |
| NEUT-406CQ | Rat Anti-Cd70 Recombinant Antibody (clone FR70) | FC, FuncS, Neut, IP | Rat IgG2b, κ |
| NEUT-407CQ | Rat Anti-Cd70 Recombinant Antibody (clone CBL856) | ELISA, Neut | Rat IgG1 |
Blocking Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-404CQ | Rat Anti-Cd70 Recombinant Antibody (clone MAB0825) | Block, FC, Inhib, IP | Rat IgG2 |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0095-LSX | Human Anti-CD70 Recombinant Antibody (HPAB-0095-LSX) | ELISA, FC, ADCC, FuncS | Human IgG |
| HPAB-0096-LSX | Human Anti-CD70 Recombinant Antibody (HPAB-0096-LSX) | ELISA, FC, Block, FuncS | Human IgG |
| HPAB-0097-LSX | Human Anti-CD70 Recombinant Antibody (HPAB-0097-LSX) | ELISA, FC, Block, FuncS | Human IgG |
| FN-046CQ | Mouse Anti-CD70 Recombinant Antibody (clone BU69) | ELISA, FC, Block, ICC, IHC | Mouse IgG1 |
| VS-0723-WK5 | Human Anti-CD70 Recombinant Antibody (VS-0723-WK5) | FC | Human IgG1 |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-M0487-YC-S(P) | Rat Anti-CD70 Recombinant Antibody (clone 4F2-12); scFv Fragment | FC | Rat scFv |
| HPAB-AP586-YC-S(P) | Human Anti-CD70 Recombinant Antibody (clone h1F6-HHLA); scFv Fragment | FC, ADCC, CDC, FuncS | Humanized (mouse/human) scFv |
| HPAB-AP587-YC-S(P) | Human Anti-CD70 Recombinant Antibody (clone h1F6-HELA); scFv Fragment | FC, ADCC, CDC, FuncS | Humanized (mouse/human) scFv |
| HPAB-AP588-YC-S(P) | Human Anti-CD70 Recombinant Antibody (clone h1F6-HJLA); scFv Fragment | FC, ADCC, CDC, FuncS | Humanized (mouse/human) scFv |
| HPAB-AP589-YC-S(P) | Human Anti-CD70 Recombinant Antibody (clone h1F6-HMLA); scFv Fragment | ELISA, Cyt, FuncS | Human scFv |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-M0487-YC-F(E) | Rat Anti-CD70 Recombinant Antibody (clone 4F2-12); Fab Fragment | FC | Rat Fab |
| HPAB-0468-WJ-F(E) | Human Anti-CD70 Recombinant Antibody; Fab Fragment (HPAB-0468-WJ-F(E)) | ELISA | Human Fab |
| HPAB-0469-WJ-F(E) | Human Anti-CD70 Recombinant Antibody; Fab Fragment (HPAB-0469-WJ-F(E)) | ELISA | Human Fab |
| HPAB-0470-WJ-F(E) | Human Anti-CD70 Recombinant Antibody; Fab Fragment (HPAB-0470-WJ-F(E)) | ELISA | Human Fab |
| HPAB-0471-WJ-F(E) | Human Anti-CD70 Recombinant Antibody; Fab Fragment (HPAB-0471-WJ-F(E)) | ELISA | Human Fab |
ADCC Enhanced Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-H76 | Afuco™ Anti-CD70 ADCC Recombinant Antibody (Vorsetuzumab), ADCC Enhanced | ELISA, FC, IP, FuncS, IF, Neut | ADCC enhanced antibody |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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