Mouse Anti-CD70 Recombinant Antibody (clone m1F6) (CAT#: HPAB-AP584-YC)
Provided are recombinant anti-CD70 antibodies, that exert a cytotoxic, cytostatic or immunomodulatory on CD70 expressing cells. The antibody could be used for the prophylaxis or treatment of CD70-expressing cancers and immunological disorders where CD70-expressing cells are present.
Specific Inquiry
ICC
Figure 1 Subcellular localization, microtubule-disrupting, and anti-mitotic activities of 1F6 ADCs.
786-O cells were treated with the indicated mAb, ADCs, or free AFP. Microtubule organization was examined by an anti-a-tubulin antibody and counterstained with AF488-conjugated goat anti-mouse IgG while nuclei were counterstained with DAPI. One to three representative cells from each treatment are shown.
Law, C. L., Gordon, K. A., Toki, B. E., Yamane, A. K., Hering, M. A., Cerveny, C. G., ... & Sauter, G. (2006). Lymphocyte activation antigen CD70 expressed by renal cell carcinoma is a potential therapeutic target for anti-CD70 antibody-drug conjugates. Cancer Research, 66(4), 2328-2337.
FC
Figure 2 Subcellular localization, microtubule-disrupting, and anti-mitotic activities of 1F6 ADCs.
Cell cycle distribution and DNA synthesis in 786-O cells at progressive time points after m1F6, m1F6-vcAFP8, or IgG-vcAFP8 treatment was determined by anti-bromodeoxyuridine and propidium iodide staining and flow cytometry. G0-G1, S, G2-M, and apoptotic events were defined on the dual-color dot plots as described before. Percentages of cells in different phases of the cell cycle were plotted against time after drug treatment.
Law, C. L., Gordon, K. A., Toki, B. E., Yamane, A. K., Hering, M. A., Cerveny, C. G., ... & Sauter, G. (2006). Lymphocyte activation antigen CD70 expressed by renal cell carcinoma is a potential therapeutic target for anti-CD70 antibody-drug conjugates. Cancer Research, 66(4), 2328-2337.
Specifications
- Host Species
- Mouse
- Type
- Mouse IgG
- Specificity
- Human CD70
- Species Reactivity
- Human, Mouse
- Clone
- m1F6
- Applications
- FC, ADCC, CDC, FuncS
- Related Disease
- Cancer
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- The CD70 antibody has been reported in applications of Immunocytochemistry, Flow Cytometry, Functional Assay.
Target
- Alternative Names
- CD70 Molecule; Tumor Necrosis Factor Ligand Superfamily Member 7; CD70 Antigen; CD27 Ligand; CD27LG; TNFSF7; CD27-L
- Gene ID
- 970
- UniProt ID
- P32970
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "Clone m1F6"
See other products for "CD70"
Select a product category from the dropdown menu below to view related products.
Please select product type
Humanized Antibody
Human Antibody
Neutralizing Antibody
Blocking Antibody
Fab Fragment Antibody
ADCC Enhanced Antibody
Recombinant Antibody
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-H76 | Anti-Human CD70 Recombinant Antibody (Vorsetuzumab) | ELISA, FC, IP, FuncS, IF, Neut, ICC | IgG1 - kappa |
| TAB-882 | Anti-Human CD70 Recombinant Antibody (Vorsetuzumab Mafodotin) | ELISA, FC, IP, FuncS, IF, Neut, ICC | IgG1 - kappa |
| TAB-335LC | Human Anti-CD70 Recombinant Antibody (TAB-335LC) | ELISA | Humanized IgG1, κ |
| TAB-342LC | Human Anti-CD70 Recombinant Antibody (TAB-342LC) | FC | Humanized IgG |
| TAB-343LC | Human Anti-CD70 Recombinant Antibody (TAB-343LC) | FC | Humanized IgG |
Customer Reviews and Q&As
There are currently no Customer reviews or questions for HPAB-AP584-YC. Click the button above to contact us or submit your feedback about this product.
Popular products with customers
Application: ELISA, FC, IP, FuncS, IF, Neut, ICC
Application: FC, IP, ELISA, Neut, FuncS, IF, ICC
Application: WB, ELISA, FC, IP, FuncS, IF, Neut
Application: ELISA, IP, FC, FuncS, Neut, IF, ICC
Application: Neut, ELISA, WB, SPR, IF, EM
Application: ELISA, Activ, Block
Application: ELISA, FuncS, RIA, IP, IF, IHC, IA, Block
For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
