Anti-CD80 (clone AB007) Recombinant Antibody Coupled Liposome (VS-1024-FY5)
CAT#: VS-1024-FY5
Anti-CD80 antibody liposomes are a nanoscale delivery system designed to enhance the immune response of antigen-presenting cells. By binding to the CD80 molecules on the surface of dendritic cells, they promote T cell activation, thereby strengthening the immune response against specific antigens. The design of these liposomes allows for effective delivery of antigens, leading to a more robust anti-tumor immune response. Studies suggest that their mechanism may involve alterations in cytokine expression and the enhancement of specific immune responses.
Gene Expression
Normal Tissue
Figure 1 Bone marrow
Hematopoietic cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/25368/56116_B_6_4.jpg
Normal Tissue
Figure 2 Lymph node
Germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/25368/56076_A_9_8.jpg
RNA Expression
Figure 3 RNA cell line category: Cell line enhanced (Daudi, HDLM-2, Karpas-707, U-266/70)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000121594-CD80
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More Infomation
Specifications
- Potential Clinical Applications
- Specific targeting of dendritic cells
Product Composition
- Clone
- AB007
- Antibody Type
- IgG
- Antibody Host
- Mouse
- Antibody Reactivity
- Human
- Antibody Description
- This is a recombinant monoclonal antibody targeting CD8, developed for the treatment of B-cell lymphoma.
Product Property
- Storage
- See in the COA
- Storage Shelf Time
- See in the COA
Target Information
- Target
- CD80
- Introduction
- CD80 (CD80 Molecule) is a Protein Coding gene. Diseases associated with CD80 include Focal Segmental Glomerulosclerosis and Vaccinia. Among its related pathways are PEDF Induced Signaling and Cytokine Signaling in Immune system. Gene Ontology (GO) annotations related to this gene include coreceptor activity. An important paralog of this gene is CD86.
- Alternative Names
- CD80 Molecule; CD80 Antigen (CD28 Antigen Ligand 1, B7-1 Antigen); B-Lymphocyte Activation Antigen B7; CTLA-4 Counter-Receptor B7.1; Activation B7-1 Antigen; CD28LG1; CD28LG; LAB7; BB1
- Full Name
- CD80 Molecule
- Gene ID
- 941
- UniProt ID
- P33681
- Cellular Localization
- Cell membrane
- Post Translation Modifications
- Palmitoylated by ZDHHC20; palmitoylation protects CD80 from ubiquitin-mediated degradation, regulating the protein stability, and ensures its accurate plasma membrane localization. ( P33681-CD80_HUMAN )
Glycosylation at Asn53, Asn89, Asn98, Asn186, Asn207, Asn211, Asn226, and Asn232 ( NX_P33681 [NX_P33681-1] )
Modification sites at PhosphoSitePlus ( P33681 )
Glycosylation from GlyGen (P33681) 8 sites, 2 N-linked glycans (1 site)
- Protein Refseq
- NP_005182.1
- Function
- Acts as the primary auxiliary signal augmenting the MHC/TCR signal in naive T-cells together with the CD28 receptor which is constitutively expressed on the cell surface of T-cells.
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Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "Clone AB007"
- CAT
- Product Name
See other products for "CD80"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-215 | Anti-Human CD80 Recombinant Antibody (Galiximab) | WB, ELISA, FC, IP, FuncS, IF, Neut | IgG1 - lambda |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AGTO-L001G | anti-CD80 immunotoxin 6G7 (IgG)-Gel | Cytotoxicity assay, Functional assay | |
| AGTO-L001S | anti-CD80 immunotoxin 6G7 (IgG)-Sap | Cytotoxicity assay, Functional assay | |
| AGTO-L001O | anti-CD80 immunotoxin 6G7 (IgG)-Bouganin | Cytotoxicity assay, Functional assay |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-347LC | Mouse Anti-CD80 Recombinant Antibody (TAB-347LC) | FC | Mouse IgG |
| TAB-347LC-S(P) | Mouse Anti-CD80 Recombinant Antibody; scFv Fragment (TAB-347LC-S(P)) | FC | Mouse scFv |
| TAB-347LC-F(E) | Mouse Anti-CD80 Recombinant Antibody; Fab Fragment (TAB-347LC-F(E)) | FC | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-159LC | Recombinant Anti-Human CD80 Antibody (Fc glycosylation/Non fucosylated) | ELISA | Chimeric antibody (primate/human) |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-159LC-1 | Recombinant Anti-Human CD80 Antibody (Fc glycosylation/Non fucosylated) | ELISA | Chimeric antibody (primate/human) |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0490CT | Recombinant Mouse anti-Human CD80 Monoclonal antibody (NFN-344) | FC | |
| MRO-1762-CN | Rabbit Anti-CD80 Polyclonal Antibody (MRO-1762-CN) | WB, IF, IHC, FC | Rabbit IgG |
| FN-164CQ | Mouse Anti-CD80 Recombinant Antibody (clone CBL-1325) | FC, FuncS | Mouse IgG1, κ |
| HPAB-0708-FY | Mouse Anti-CD80 Recombinant Antibody (clone AB007) | ELISA | Mouse IgG |
| HPAB-1587WJ | Mouse Anti-CD80 Recombinant Antibody (clone 1F1) | ELISA, WB | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0066MZ | Chicken Anti-BB1 Polyclonal IgY | WB | Chicken antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-409CQ | Mouse Anti-CD80 Recombinant Antibody (clone CBL764) | FC, IHC, CyTOF®, ELISA, Neut | Mouse IgG1 |
| NEUT-410CQ | Mouse Anti-CD80 Recombinant Antibody (clone 6N36) | FC, IHC, Neut, WB | Mouse IgG1 |
| NEUT-411CQ | Mouse Anti-CD80 Recombinant Antibody (clone AS29) | IP, Neut | Mouse IgG1 |
| NEUT-412CQ | Mouse Anti-CD80 Recombinant Antibody (VMC172) | Neut, FC | Mouse IgG1 |
| NEUT-415CQ | Hamster Anti-Cd80 Recombinant Antibody (clone 16-10A1) | FC, FuncS, Neut, IHC, IHC-Fr | Hamster IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-413CQ | Rat Anti-Cd80 Recombinant Antibody (clone 1G10) | IP, Block | Rat IgG2a, κ |
| NEUT-414CQ | Hamster Anti-Cd80 Recombinant Antibody (NEUT-414CQ) | Block, FC, IHC-Fr | Hamster IgG |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0583 | Hi-Affi™ Rabbit Anti-CD80 Recombinant Antibody (clone DS583AB) | WB, IHC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-215 | Afuco™ Anti-CD80 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-215) | ELISA, FC, IP, FuncS, IF | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FN-040CQ | Mouse Anti-CD80 Recombinant Antibody (FN-040CQ) | FC, ELISA, WB, Block | Mouse IgM, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0063-YJ-S(P) | Human Anti-CD80 Recombinant Antibody (clone hu1F1); scFv Fragment | ELISA, FuncS | Humanized scFv |
| HPAB-0708-FY-F(E) | Mouse Anti-CD80 Recombinant Antibody (clone AB007); scFv Fragment | ELISA | Mouse scFv |
| HPAB-1587WJ-S(P) | Mouse Anti-CD80 Recombinant Antibody; scFv Fragment (clone 1F1) | ELISA, WB | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0063-YJ-F(E) | Human Anti-CD80 Recombinant Antibody (clone hu1F1); Fab Fragment | ELISA, FuncS | Humanized Fab |
| HPAB-0708-FY-S(P) | Mouse Anti-CD80 Recombinant Antibody (clone AB007); Fab Fragment | ELISA | Mouse Fab |
| HPAB-1587WJ-F(E) | Mouse Anti-CD80 Recombinant Antibody; Fab Fragment (clone 1F1) | ELISA, WB | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0424-XY56 | AbPlus™ Anti-CD80 Magnetic Beads (AS29) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0225-XY73 | CytoStream™ Mouse Anti-CD80 Recombinant Antibody (clone 2D10.4) | FC | Mouse IgG1, kappa |
| VS13-YC175 | CytoStream™ Hamster Anti-Mouse Cd80 Recombinant Antibody (VS13-YC175) | FC | Armenian hamster IgG |
| VS13-YC176 | CytoStream™ Rabbit Anti-CD80 Recombinant Antibody (VS13-YC176) | FC, ELISA | Rabbit IgG |
| VS13-YC177 | CytoStream™ Mouse Anti-CD80 Recombinant Antibody (VS13-YC177) | WB, IHC-P, FC, ICC | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-FY9 | Mouse Anti-CD80 (clone AB007) scFv-Fc Chimera | IA | Mouse IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC176 | Recombinant Anti-CD80 Vesicular Antibody, EV Displayed (VS-0425-YC176) | ELISA, FC, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY1224 | Anti-Mouse CD80 Immunohistochemistry Kit | IHC |
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