Anti-IGF1R Antibody Prodrug, Protease Activated (VS-1025-YC73)
CAT#: VS-1025-YC73
The Anti-IGF1R Antibody Prodrug, Protease Activated (VS-1025-YC73) is an antibody prodrug comprised of a recombinant human antibody targeting human IGF1R, linked to a masking peptide that conceals the active antigen-binding site via a protease-cleavable linker. The mask peptide is recombinantly attached to the amino terminus of either the light or heavy chain of the antibody, designed to block access to the antigen-binding site and physically prevent the antibody from binding to IGF1R protein. Once the masking peptide is cleaved by matrix metalloproteinases (MMPs), the prodrug is activated, allowing the unmasked monoclonal antibody component to bind to IGF1R effectively. IGF1R (Insulin-like Growth Factor 1 Receptor) is a receptor tyrosine kinase that promotes cell survival and inhibits apoptosis, often mediating resistance to chemotherapy and radiotherapy. Its signaling is frequently activated in many solid tumors, making it an attractive target. Inhibition of IGF1R is studied as a way to resensitize cancer cells to treatment.
Gene Expression
Normal Tissue
Figure 1 Cerebral cortex
Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Glial cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Neuronal cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Neuropil
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10268/32662_B_7_5.jpg
Normal Tissue
Figure 2 Colon
Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Glandular cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10268/32662_A_7_3.jpg
Normal Tissue
Figure 3 Liver
Cholangiocytes
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Hepatocytes
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10268/32662_A_8_4.jpg
Normal Tissue
Figure 4 Kidney
Cells in glomeruli
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Cells in tubules
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10268/32662_A_7_5.jpg
Normal Tissue
Figure 5 Testis
Cells in seminiferous ducts
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Leydig cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10268/32662_A_6_6.jpg
Normal Tissue
Figure 6 Heart muscle
Cardiomyocytes
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10268/32662_B_5_6.jpg
Normal Tissue
Figure 7 Lymph node
Germinal center cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10268/32662_A_7_8.jpg
RNA Expression
Figure 8 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000140443-IGF1R
❮
❯
Specifications
- Host Animal
- Human
- Applications
- In situ zymography (ISZ), Cytotoxicity assay (Cyt), Functional assay
- Specificity
- Human IGF1R
- Target
- IGF1R
- Species Reactivity
- Human
- Isotype
- IgG
- Epitope
- IGF1R-ECD
- Masking Approach
- Affinity mask
- Mask
- A synthetic peptide
- Protease Cleavable Linker
- MMP-cleavable linker
- Protease Substrate
- MMPs
- Purification
- Protein A purified
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Target
- Introduction
- This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
- Alternative Names
- IGFR; CD221; IGFIR; JTK13
- Gene ID
- 3480
- UniProt ID
- P08069
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Related Signaling Pathways
Insulin Signaling Pathway
Related Diseases
Endocrine Resistance
Type I Diabetes Mellitus
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Datasheet
MSDS
COA
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| TAB-209 | Anti-Human IGF1 Receptor Recombinant Antibody (TAB-209) | FuncS, IF, Neut, ELISA, FC, IP, ICC | IgG1 - kappa |
| TAB-052ZJ | Anti-Human IGF-1R Recombinant Antibody (TAB-052ZJ) | IHC, ELISA, FC, IF, IP | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-736 | Anti-IGF1R Recombinant Antibody (TAB-736) | FC, IP, ELISA, Neut, FuncS, IF, ICC | IgG1 - kappa |
| TAB-386CL | Humanized Anti-IGF1R Recombinant Antibody (TAB-386CL) | FuncS | Humanized IgG |
| TAB-035ZJ | Human Anti-IGF1R Recombinant Antibody (TAB-035ZJ) | ELISA, FC | Humanized IgG |
| TAB-036ZJ | Anti-Human IGF-1R Recombinant Antibody (H0L0 IgGIm(AA)) | ELISA, Neut, FC, IHC | Humanized antibody |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| AGTO-L024E | IGF1-PE immunotoxin | Cytotoxicity assay, Functional assay | |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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| AFC-TAB-209 | Afuco™ Anti-IGF1R ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-209) | FuncS, IF, Neut, ELISA, FC, IP | ADCC enhanced antibody |
| AFC-TAB-736 | Afuco™ Anti-IGF1R ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-736) | FC, IP, ELISA, Neut, FuncS, IF | ADCC enhanced antibody |
| AFC-TAB-078 | Afuco™ Anti-IGF1R ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-078) | IF, IP, Neut, FuncS, ELISA, FC | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBL-591 | Mouse Anti-IGF1R Recombinant Antibody (clone mAb 83-14); Fab Fragment | WB, ELISA, FuncS | Mouse Fab |
| PFBL-592 | Mouse Anti-IGF1R Recombinant Antibody (clone mAb 83-7); Fab Fragment | WB, ELISA, FuncS | Mouse Fab |
| HPAB-0084-YC-F(E) | Human Anti-IGF1R Recombinant Antibody; Fab Fragment (HPAB-0084-YC-F(E)) | ELISA, FC | Humanized Fab |
| HPAB-0085-YC-F(E) | Human Anti-IGF1R Recombinant Antibody; Fab Fragment (HPAB-0085-YC-F(E)) | Block, FuncS, FC, ELISA | Human Fab |
| HPAB-0210CQ-F(E) | Human Anti-IGF1R Recombinant Antibody (clone 15H12); Fab Fragment | ELISA, FC, Neut | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBL-591 | Mouse Anti-IGF1R Recombinant Antibody (clone mAb 83-14); scFv Fragment | WB, ELISA, FuncS | Mouse scFv |
| PSBL-592 | Mouse Anti-IGF1R Recombinant Antibody (clone mAb 83-7); scFv Fragment | WB, ELISA, FuncS | Mouse scFv |
| HPAB-0084-YC-S(P) | Human Anti-IGF1R Recombinant Antibody; scFv Fragment (HPAB-0084-YC-S(P)) | ELISA, FC | Human scFv |
| HPAB-0085-YC-S(P) | Human Anti-IGF1R Recombinant Antibody; scFv Fragment (HPAB-0085-YC-S(P)) | Block, FuncS, FC, ELISA | Human scFv |
| HPAB-0210CQ-S(P) | Human Anti-IGF1R Recombinant Antibody (clone 15H12); scFv Fragment | ELISA, FC, Neut | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-009ZJ | Mouse Anti-IGF1R Recombinant Antibody (TAB-009ZJ) | ELISA, FC | Mouse IgG1, κ |
| TAB-010ZJ | Anti-Human IGF-1R Recombinant Antibody (6E11) | ELISA, Neut, FC, IHC | |
| TAB-011ZJ | Mouse Anti-IGF1R Recombinant Antibody (TAB-011ZJ) | ELISA, FC, WB, Inhib | Mouse IgG2, κ |
| TAB-012ZJ | Mouse Anti-IGF1R Recombinant Antibody (TAB-012ZJ) | ELISA, FC, WB, Inhib | Mouse IgG2, κ |
| TAB-013ZJ | Anti-Human IGF-1R Recombinant Antibody (1H7) | WB, Inhib |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-084ZJ | Human Anti-IGF1R Recombinant Antibody (TAB-084ZJ) | WB, Inhib, ELISA, FC | Chimeric (mouse/human) IgG |
| TAB-085ZJ | Anti-Human IGF-1R Recombinant Antibody (6E11c) | ELISA, FC, IHC, Inhib | Chimeric antibody (mouse/human) |
| TAB-086ZJ | Human Anti-IGF1R Recombinant Antibody (TAB-086ZJ) | ELISA, FC, Inhib, IP | Chimeric (mouse/human) IgG1 |
| TAB-087ZJ | Anti-Human IGF-1R Recombinant Antibody (ch7C2) | ELISA | Chimeric antibody (mouse/human) |
| TAB-093ZJ | Anti-Human IGF-1R Recombinant Antibody (ch9E11) | ELISA | Chimeric antibody (mouse/human) |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0103MZ | Chicken Anti-CD221 Polyclonal IgY | WB | Chicken antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1075CQ | Mouse Anti-IGF1R Recombinant Antibody (clone alphaIR3) | FC, IP, Neut, ICC, IF | Mouse IgG1 |
| NEUT-1076CQ | Mouse Anti-IGF1R Recombinant Antibody (clone 33255.111) | ELISA, Neut, WB | Mouse IgG1 |
| NEUT-1081CQ | Mouse Anti-IGF1R Recombinant Antibody (clone CBL453) | WB, ELISA, Neut | Mouse IgG1 |
| NEUT-1082CQ | Mouse Anti-IGF1R Recombinant Antibody (clone CBL080) | Neut, WB | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1077CQ | Mouse Anti-IGF1R Recombinant Antibody (clone 1H7) | FC, Block, IHC, IP, WB | Mouse IgG1, κ |
| NEUT-1078CQ | Mouse Anti-IGF1R Recombinant Antibody (clone 24-60) | Inhib, ICC, IF, IP, WB | Mouse IgG2a, κ |
| NEUT-1079CQ | Mouse Anti-IGF1R Recombinant Antibody (clone 17-69) | Inhib, IP | Mouse IgG1 |
| NEUT-1080CQ | Mouse Anti-IGF1R Recombinant Antibody (clone 24-57) | Inhib, IP | Mouse IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1755 | Rabbit Anti-IGF1R Recombinant Antibody (clone DS1755AB) | IP, ELISA | Rabbit IgG |
| MOR-4684 | Rabbit Anti-IGF1R Recombinant Antibody (clone TH198DS) | WB, ELISA | Rabbit IgG |
| MOR-4685 | Rabbit Anti-IGF1R Recombinant Antibody (clone TH199DS) | WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NS-041CN | Mouse Anti-IGF1R Recombinant Antibody (NS-041CN) | ELISA, WB, FC | Mouse IgG |
| NS-041CN-F(E) | Mouse Anti-IGF1R Recombinant Antibody; Fab Fragment (NS-041CN-F(E)) | ELISA, WB, FC | Mouse Fab |
| NS-041CN-S(P) | Mouse Anti-IGF1R Recombinant Antibody; scFv Fragment (NS-041CN-S(P)) | ELISA, WB, FC | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0424-XY145 | AbPlus™ Anti-IGF1R Magnetic Beads (9E11) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0125-FY20 | Human Anti-IGF1R (clone 1H3) scFv-Fc Chimera | ELISA, FC, Neut, Inhib | Human IgG1, scFv-Fc |
| VS-0325-FY85 | Human Anti-IGF1R (clone 7C10) scFv-Fc Chimera | ELISA, FC, Inhib | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY1101 | Anti-IGF1R Immunohistochemistry Kit | IHC | |
| VS-0525-XY3431 | Anti-Mouse IGF1R Immunohistochemistry Kit | IHC | |
| VS-0525-XY3430 | Anti-Human IGF1R Immunohistochemistry Kit | IHC | |
| VS-0525-XY3432 | Anti-Rat IGF1R Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC366 | Recombinant Anti-IGF1R Vesicular Antibody, EV Displayed (VS-0425-YC366) | ELISA, FC, Neut, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-YC108 | Recombinant Anti-IGF1R (AA 62-184 x AA 283-440) Biparatopic Antibody, Tandem scFv (Clone 4-52 x Clone 45742) | ELISA | Tandem scFv |
| VS-0525-YC107 | Recombinant Anti-IGF1R (AA 283-440 x AA 440-514) Biparatopic Antibody, Tandem scFv (Clone 45742 x Clone 24-55) | ELISA | Tandem scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0825-YC167 | SmartAb™ Recombinant Anti-IGF1R pH-dependent Antibody (Clone DalotuzumAb) | ELISA, IHC, FC, IP, IF, WB | Human IgG1 kappa |
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