Recombinant Anti-IGF1R (AA 283-440 x AA 440-514) Biparatopic Antibody, Tandem scFv (Clone 45742 x Clone 24-55) (CAT#: VS-0525-YC107)

• Host Animal 1
• Mouse

• Host Animal 2
• Mouse

• Specificity
• Human insulin-like growth factor 1 receptor (IGF1R)

• Species Reactivity
• Human

• Type
• Tandem scFv

• Valency
• 1 + 1

• Clone 1
• 45742

• Clone 2
• 24-55

• Epitope 1
• aa 283-440

• Epitope 2
• aa 440-514

• Purity
• >90%

• Purification
• Affinity purified

• Applications
• ELISA

• Concentration
• Lot specific

• Buffer
• PBS, pH 7.4

• Preservative
• No preservatives

• Storage
• Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid freeze-thaw cycles.

• Long Name
• Insulin Like Growth Factor 1 Receptor

• Introduction
• This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

• Alternative Names
• Insulin Like Growth Factor 1 Receptor

• Gene ID
• 3480

• UniProt ID
• P08069

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