Recombinant Anti-IGF1R (AA 283-440 x AA 440-514) Biparatopic Antibody, Tandem scFv (Clone 45742 x Clone 24-55)

Name: Recombinant Anti-IGF1R (AA 283-440 x AA 440-514) Biparatopic Antibody, Tandem scFv (Clone 45742 x Clone 24-55)
SKU: VS-0525-YC107
Rating: 5 (1 reviews)

CAT#: VS-0525-YC107

The Recombinant Anti-IGF1R (AA 283-440 x AA 440-514) Biparatopic Antibody, Tandem scFv (Clone 45742 x Clone 24-55) is a biparatopic antibody (bpAb) that recognizes two unique IGF1R epitopes. This bpAb's tandem scFv construct joins the 45742 scFv (binding amino acids 283-440 of IGF1R) N-terminally to the 24-55 scFv (targeting amino acids 440-514 of IGF1R).

Gene Expression

Normal Tissue Figure 1 Cerebral cortex

Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Glial cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Neuronal cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Neuropil
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10268/32662_B_7_5.jpg

Normal Tissue Figure 2 Colon

Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Glandular cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10268/32662_A_7_3.jpg

Normal Tissue Figure 3 Liver

Cholangiocytes
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Hepatocytes
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10268/32662_A_8_4.jpg

Normal Tissue Figure 4 Kidney

Cells in glomeruli
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Cells in tubules
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10268/32662_A_7_5.jpg

Normal Tissue Figure 5 Testis

Cells in seminiferous ducts
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Leydig cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10268/32662_A_6_6.jpg

Normal Tissue Figure 6 Heart muscle

Cardiomyocytes
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10268/32662_B_5_6.jpg

Normal Tissue Figure 7 Lymph node

Germinal center cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10268/32662_A_7_8.jpg

RNA Expression Figure 8 RNA cell line category: Low cell line specificity

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000140443-IGF1R

❮

❯

Specifications

Host Animal 1
Mouse

Host Animal 2
Mouse

Specificity
Human insulin-like growth factor 1 receptor (IGF1R)

Species Reactivity
Human

Type
Tandem scFv

Valency
1 + 1

Clone 1
45742

Clone 2
24-55

Epitope 1
aa 283-440

Epitope 2
aa 440-514

Purity
>90%

Purification
Affinity purified

Applications
ELISA

Concentration
Lot specific

Buffer
PBS, pH 7.4

Preservative
No preservatives

Storage
Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid freeze-thaw cycles.

Long Name
Insulin Like Growth Factor 1 Receptor

Target

Introduction
This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

Alternative Names
Insulin Like Growth Factor 1 Receptor

Gene ID
3480

UniProt ID
P08069

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Related Signaling Pathways

Insulin Signaling Pathway

Related Diseases

Endocrine Resistance

Type I Diabetes Mellitus

Downloadable Resources

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Datasheet

Datasheet - VS-0525-YC107.pdf

MSDS

MSDS - VS-0525-YC107.pdf

COA

Certificate of Analysis Lookup

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