Popular Searches: Recombinant Antibody MHC Tetramer T cell Receptor Scaffold Protein

IGF1-DT immunotoxin (CAT#: AGTO-L024D)

This immunotoxin was achieved by conjugating/fusing the IGF1 to Diphtheria toxin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to cancer cells. Once bind, the toxin enters cells by receptor-mediated endocytosis, then Before the N-terminal 193 amino acids corresponding to the catalytic domain of DT enzyme; -II binding and elongation factor into the eukaryotic cell; the cell can catalyze specific elongation factor EF2 amide His699 of diphtheria ADP2 ribosylation occurs; thereby preventing protein synthesis and causes cell death. It was designed for treatment of breast, prostate, and lung cancers.

See more Engineered Antibody products for IGF1R
Specific Inquiry
  • Size:
  • Conjugation:
  • Endotoxin:
  • Purity:
  • Fc Engineering:
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Normal Tissue
Figure 1 Cerebral cortex
Figure 1 Cerebral cortex
(Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Glial cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Neuronal cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Neuropil
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10268/32662_B_7_5.jpg
Figure 2 Colon
Figure 2 Colon
(Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Glandular cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10268/32662_A_7_3.jpg
Figure 3 Liver
Figure 3 Liver
(Cholangiocytes
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Hepatocytes
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10268/32662_A_8_4.jpg
Figure 4 Kidney
Figure 4 Kidney
(Cells in glomeruli
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Cells in tubules
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10268/32662_A_7_5.jpg
Figure 5 Testis
Figure 5 Testis
(Cells in seminiferous ducts
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Leydig cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10268/32662_A_6_6.jpg
Figure 6 Heart muscle
Figure 6 Heart muscle
(Cardiomyocytes
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10268/32662_B_5_6.jpg
Figure 7 Lymph node
Figure 7 Lymph node
(Germinal center cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10268/32662_A_7_8.jpg
RNA Expression
Figure 8 RNA cell line category: Low cell line specificity
Figure 8 RNA cell line category: Low cell line specificity
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000140443-IGF1R
Figure 8 RNA cell line category: Low cell line specificity
Figure 8 RNA cell line category: Low cell line specificity
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000140443-IGF1R

Specifications

  • Host Species
  • Human
  • Species Reactivity
  • Human
  • Molecule Class
  • IGF1-DT
  • Toxin Description
  • Diphtheria toxin (Diphtheriatoxin, DT) is a cell toxin produced by diphtheria, is a protein toxin most commonly used in the construction of recombinant immunotoxin. Before the N-terminal 193 amino acids corresponding to the catalytic domain of DT enzyme, -II binding and elongation factor into the eukaryotic cell, the cell can catalyze specific elongation factor EF2 amide His699 of diphtheria ADP2 ribosylation occurs, thereby preventing protein synthesis and causes cell death.
  • Applications
  • This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
  • Related Disease
  • Breast, prostate, and lung cancers

Target

  • Alternative Names
  • IGF1R; insulin-like growth factor 1 receptor; IGFR; CD221; IGFIR; JTK13; IGF-I receptor; soluble IGF1R variant 1; soluble IGF1R variant 2; insulin-like growth factor I receptor; Diphtheria toxin; Diphtheria-toxin; DT; DT388; DT389; DT390; DAB389

Related Resources

  • Related Signaling Pathways
  • Related Diseases

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "IGF1R"

Select a product category from the dropdown menu below to view related products.
Please select product type
Single-domain Antibody Immunotoxin ADCC Enhanced Antibody Fab Fragment Antibody Mouse Antibody Human Antibody Chimeric Antibody Humanized Antibody Chicken IgY Antibody Neutralizing Antibody Blocking Antibody Rabbit Monoclonal Antibody Recombinant Antibody Neuroscience Antibody scFv Fragment Antibody
CAT Product Name Application Type
NABL-091 Recombinant Anti-human IGF1R VHH Single Domain Antibody WB, ELISA, IHC, FC, FuncS Llama VHH
TAB-096ZJ Anti-Human IGF-1R Therapeutic Single Domain Antibody (TAB-096ZJ) ELISA, IHC, IF, WB Single domain antibody
HPAB-1545-FY Recombinant Llama Anti-IGF1R Single Domain Antibody (HPAB-1545-FY) WB, ELISA Llama VHH
HPAB-1546-FY Recombinant Llama Anti-IGF1R Single Domain Antibody (HPAB-1546-FY) WB, ELISA Llama VHH
HPAB-1547-FY Recombinant Llama Anti-IGF1R Single Domain Antibody (HPAB-1547-FY) WB, ELISA Llama VHH

Customer Reviews and Q&As

Submit a review or a question

There are currently no Customer reviews or questions for AGTO-L024D. Click the button above to contact us or submit your feedback about this product.

Popular products with customers

Figure 1 Anti-Human TNF beta Antibody (TAB-071) in WB

Anti-Human TNF beta Recombinant Antibody (Pateclizumab) (CAT# TAB-071)
Application: Neut, ELISA, IF, IP, FuncS, FC, ICC

Figure 1 Anti-SDC1 Antibody (TAB-197) in WB

Chimeric (Mouse/Human) Anti-SDC1 Recombinant Antibody (clone Indatuximab) (CAT# TAB-197)
Application: Neut, ELISA, IF, IP, FuncS, FC, ICC

Figure 1 Anti-Human CXCR4 Recombinant Antibody (TAB-H72) in SDS-PAGE

Anti-Human CXCR4 Recombinant Antibody (Ulocuplumab) (CAT# TAB-H72)
Application: IP, IF, FuncS, FC, Neut, ELISA, ICC

Figure 1 IGF1R Recombinant Antibody (TAB-736) in SDS-PAGE

Anti-IGF1R Recombinant Antibody (Dalotuzumab) (CAT# TAB-736)
Application: FC, IP, ELISA, Neut, FuncS, IF, ICC

Figure 1 Anti-ERBB3 Recombinant Antibody (TAB-892) in ELISA

Anti-Human ERBB3/ErbB 3 Recombinant Antibody (Seribantumab) (CAT# TAB-892)
Application: IF, IP, Neut, FuncS, ELISA, FC, ICC

Figure 1 Anti-Human MUC5AC Recombinant Antibody (TAB-200) in SDS-PAGE

Anti-Human MUC5AC Recombinant Antibody (Ensituximab) (CAT# TAB-200)
Application: IP, IF, FuncS, FC, Neut, ELISA, ICC

Figure 1 Anti-Human IL5 Recombinant Antibody (TAB-031) in SDS-PAGE

Anti-Human IL5 Recombinant Antibody (Mepolizumab) (CAT# TAB-031)
Application: IF, IP, Neut, FuncS, ELISA, FC, ICC

Figure 1 Anti-Human VEGF Recombinant Antibody (TAB-011) in WB

Anti-Human VEGF Recombinant Antibody (Bevacizumab) (CAT# TAB-011)
Application: FC, IP, ELISA, Neut, FuncS, IF, ICC

Figure 1 Anti-Human IL21R Recombinant Antibody (TAB- 416CL) in WB

Anti-Human IL21R Recombinant Antibody (PF-05230900) (CAT# TAB-416CL)
Application:

Figure 1 Anti-Human Laminin-332 Recombinant Antibody (TAB-481CL) in SDS-PAGE

Anti-Human Laminin-332 Recombinant Antibody (CAT# TAB-481CL)
Application:

Figure 1 Anti-HIV-1 gp120 Antibody (PABL-163) in WB

Human Anti-HIV-1 gp120 Recombinant Antibody (clone 3bnc117) (CAT# PABL-163)
Application: Neut, ELISA, FuncS

Figure 1 Anti-C3b Antibody (PABL-420) in SDS-PAGE

Human Anti-C3b Recombinant Antibody (clone S77) (CAT# PABL-420)
Application: FuncS, Inhib, IP, ELISA

Figure 1 Mouse Anti-KIT Recombinant Antibody (PABL-642) in SDS-PAGE

Mouse Anti-KIT Recombinant Antibody (clone 79D) (CAT# PABL-642)
Application: WB, FuncS

Figure 1 Anti-CD3 Recombinant Antibody (TAB-0416CL-F(E)) in SDS-PAGE

Anti-Human CD3 Recombinant Antibody Fab Fragment (OKT3) (CAT# TAB-0416CL-F(E))
Application: IB, ELISA, FC, FuncS

Figure 1 Anti-CD28 Antibody (TAB-064LC) in ELISA

Anti-Human CD28 Recombinant Antibody (TGN1412) (CAT# TAB-064LC)
Application: FC, Stim

Figure 1 Human Anti-NOTCH4 Recombinant Antibody (HPAB-0068-CN) in SDS-PAGE

Human Anti-NOTCH4 Recombinant Antibody (HPAB-0068-CN) (CAT# HPAB-0068-CN)
Application: Neut, IF

Figure 1 Human IgG2, kappa Isotype Control Antibody (MOB-197CQ) in SDS-PAGE

Human IgG2, kappa Isotype Control Antibody (CAT# MOB-197CQ)
Application: FC, ELISA

Figure 1 Mouse Anti-MRC2 Recombinant Antibody (HPAB-M0693-YC) in SDS-PAGE

Mouse Anti-MRC2 Recombinant Antibody (HPAB-M0693-YC) (CAT# HPAB-M0693-YC)
Application: WB, FuncS

Figure 1 Recombinant Mouse Anti-Psa Fab Fragment (HPAB-3383LY-F(E)) in SDS-PAGE

Mouse Anti-Psa Recombinant Antibody; Fab Fragment (HPAB-3383LY-F(E)) (CAT# HPAB-3383LY-F(E))
Application: ELISA

Figure 1 Human Anti-IAV HA Recombinant Antibody (PABJ-0204) in SDS-PAGE

Human Anti-IAV HA Recombinant Antibody (clone FluA-20) (CAT# PABJ-0204)
Application: ELISA, Inhib, FuncS

For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

Send Inquiry

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

  • 0
  • 0
Cart
    Inquiry
    Go to compare

    Go to compare