AbPlus™ Anti-IGF1R Magnetic Beads (9E11)

Name: AbPlus™ Anti-IGF1R Magnetic Beads (9E11)
SKU: VS-0424-XY145
Rating: 5 (1 reviews)

CAT#: VS-0424-XY145

The AbPlus Anti-IGF1R Magnetic Beads (9E11) is an innovative affinity resin which is bound with anti-IGF1R specific antibody (9E11). The beads were designed for small-scale affinity purification and immunoprecipitation (IP) of IGF1R protein under native and denaturing conditions.

Gene Expression

Normal Tissue Figure 1 Cerebral cortex

Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Glial cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Neuronal cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Neuropil
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10268/32662_B_7_5.jpg

Normal Tissue Figure 2 Colon

Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Glandular cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10268/32662_A_7_3.jpg

Normal Tissue Figure 3 Liver

Cholangiocytes
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Hepatocytes
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10268/32662_A_8_4.jpg

Normal Tissue Figure 4 Kidney

Cells in glomeruli
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Cells in tubules
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10268/32662_A_7_5.jpg

Normal Tissue Figure 5 Testis

Cells in seminiferous ducts
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Leydig cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10268/32662_A_6_6.jpg

Normal Tissue Figure 6 Heart muscle

Cardiomyocytes
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10268/32662_B_5_6.jpg

Normal Tissue Figure 7 Lymph node

Germinal center cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10268/32662_A_7_8.jpg

RNA Expression Figure 8 RNA cell line category: Low cell line specificity

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000140443-IGF1R

❮

❯

Specifications

Applications
Immunoprecipitation, Protein Purification

Matrix
Magrose bead (> 50 μmol/mL gel)

Bead Ligand
Anti-IGF1R specific antibody (9E11)

Target
IGF1R

Immunogen
Recombinant soluble IGF-IR

Target Species
Human

Antibody Clone
9E11

Bead Capacity
20-30 mg/mL binding antibody

Bead size
10-37 μm

Stability
pH 2-14

Format
20% Suspension

Buffer
PBS, pH 7.4, with 1% BSA

Preservative
0.03% Proclin 300

Storage
Stored at 4°C, and is stable for up to 2 years. Do not centrifuge, dry or freeze the magnetic beads.

Applications

Application Notes
The beads are in suspension and will settle upon storage. Prior to use, mix the vial gently (do not vortex) to ensure delivery of proper bead volume.

Target

Introduction
This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

Alternative Names
IGF1R; insulin-like growth factor 1 receptor; IGFR; CD221; IGFIR; JTK13; IGF-I receptor; soluble IGF1R variant 1; soluble IGF1R variant 2; insulin-like growth factor I receptor

Gene ID
3480

UniProt ID
P08069

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Related Signaling Pathways

Insulin Signaling Pathway

Related Diseases

Endocrine Resistance

Type I Diabetes Mellitus

Downloadable Resources

Download resources about recombinant antibody development and antibody engineering to boost your research.

Datasheet

Datasheet - VS-0424-XY145.pdf

MSDS

MSDS - VS-0424-XY145.pdf

COA

Certificate of Analysis Lookup

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CAT	Product Name	Application	Type
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TAB-011ZJ-S(P)	Mouse Anti-IGF1R Recombinant Antibody; scFv Fragment (TAB-011ZJ-S(P))	ELISA, FC, WB, Inhib	Mouse scFv
TAB-012ZJ-S(P)	Mouse Anti-IGF1R Recombinant Antibody; scFv Fragment (TAB-012ZJ-S(P))	ELISA, FC, WB, Inhib	Mouse scFv
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CAT	Product Name	Application	Type
TAB-035ZJ-S(P)	Human Anti-IGF1R Recombinant Antibody; scFv Fragment (TAB-035ZJ-S(P))	ELISA, FC	Humanized scFv
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TAB-037ZJ-S(P)	Anti-Human IGF-1R Recombinant Antibody scFv Fragment (H1L0 IgGIm(AA))	ELISA, Neut, FC, IHC	Humanized antibody
TAB-038ZJ-S(P)	Human Anti-IGF1R Recombinant Antibody; scFv Fragment (TAB-038ZJ-S(P))	ELISA, FC, Inhib, IP	Humanized scFv
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MOR-1755	Rabbit Anti-IGF1R Recombinant Antibody (clone DS1755AB)	IP, ELISA	Rabbit IgG
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NS-041CN-S(P)	Mouse Anti-IGF1R Recombinant Antibody; scFv Fragment (NS-041CN-S(P))	ELISA, WB, FC	Mouse scFv

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HPAB-0210CQ	Human Anti-IGF1R Recombinant Antibody (clone 15H12)	ELISA, FC, Neut	Human IgG3, κ
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HPAB-0212CQ	Human Anti-IGF1R Recombinant Antibody (clone 11A4)	ELISA, FC, Block	Human IgG1
HPAB-0213CQ	Human Anti-IGF1R Recombinant Antibody (clone 8A1)	ELISA, FC, Block	Human IgG1
HPAB-0214CQ	Human Anti-IGF1R Recombinant Antibody (clone PINT-9A2)	ELISA, FC, Block	Human IgG1

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HPAB-0210CQ-F(E)	Human Anti-IGF1R Recombinant Antibody (clone 15H12); Fab Fragment	ELISA, FC, Neut	Human Fab
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HPAB-0212CQ-F(E)	Human Anti-IGF1R Recombinant Antibody (clone 11A4); Fab Fragment	ELISA, FC, Block	Human Fab
HPAB-0213CQ-F(E)	Human Anti-IGF1R Recombinant Antibody (clone 8A1); Fab Fragment	ELISA, FC, Block	Human Fab
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HPAB-0284-YJ-S(P)	Mouse Anti-IGF1R Recombinant Antibody; scFv Fragment (HPAB-0284-YJ-S(P))	ELISA, FC, Inhib, FuncS	Mouse scFv
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HPAB-1204-FY-F(E)	Mouse Anti-IGF1R Recombinant Antibody (clone 2C6); scFv Fragment	Inhib, ELISA	Mouse scFv
HPAB-1732-FY-F(E)	Human Anti-IGF1R Recombinant Antibody; Fab Fragment (HPAB-1732-FY-F(E))	WB, ELISA	Human Fab
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VS-0125-FY20	Human Anti-IGF1R (clone 1H3) scFv-Fc Chimera	ELISA, FC, Neut, Inhib	Human IgG1, scFv-Fc
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VS-0325-XY1101	Anti-IGF1R Immunohistochemistry Kit	IHC
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VS-0525-XY3430	Anti-Human IGF1R Immunohistochemistry Kit	IHC
VS-0525-XY3432	Anti-Rat IGF1R Immunohistochemistry Kit	IHC

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VS-0425-YC366	Recombinant Anti-IGF1R Vesicular Antibody, EV Displayed (VS-0425-YC366)	ELISA, FC, Neut, Cell-uptake

CAT	Product Name	Application	Type
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