Human Anti-IGF1R (clone 7C10) scFv-Fc Chimera

CAT#: VS-0325-FY85

The MAb 7C10 scFv-Fc is a specialized antibody designed to target the insulin-like growth factor 1 receptor (IGF1R). This antibody demonstrates significantly enhanced efficacy in inhibiting the growth of MCF-7 cancer cells in vivo. Its unique scFv-Fc structure combines the specificity of single-chain variable fragments with the functionalities of an Fc region, offering a potent therapeutic option for targeting IGF1R-related pathways in various cancer therapies.

Gene Expression
Figure 1 Cerebral cortex Figure 2 Colon Figure 3 Liver Figure 4 Kidney Figure 5 Testis Figure 6 Heart muscle Figure 7 Lymph node Figure 8 RNA cell line category: Low cell line specificity

Specifications

  • Host Species
  • Human
  • Type
  • Human IgG1, scFv-Fc
  • Specificity
  • Human IGF1R
  • Species Reactivity
  • Human
  • Clone
  • 7C10
  • Applications
  • ELISA, Flow Cytometry, Inhibition
  • Related Disease
  • Cancer

Product Property

  • Purity
  • >95% as determined by SDS-PAGE
  • Concentration
  • Please refer to the vial label for the specific concentration.
  • Storage
  • Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
  • Shipping
  • Ice packs

Target

  • Alternative Names
  • Insulin Like Growth Factor 1 Receptor
  • Long Name
  • Insulin Like Growth Factor 1 Receptor
  • Sequence Similarities
  • Belongs to the protein kinase superfamily.
  • Cellular Localization
  • Cell membrane
  • Post Translation Modifications
  • Autophosphorylated on tyrosine residues in response to ligand binding.
    Autophosphorylation occurs in trans, i.e.
    one subunit of the dimeric receptor phosphorylates tyrosine residues on the other subunit.
    Autophosphorylation occurs in a sequential manner; Tyr-1165 is predominantly phosphorylated first, followed by phosphorylation of Tyr-1161 and Tyr-1166.
  • Function
  • Receptor tyrosine kinase which mediates actions of insulin-like growth factor 1 (IGF1).
    Binds IGF1 with high affinity and IGF2 and insulin (INS) with a lower affinity.
    The activated IGF1R is involved in cell growth and survival control.
    IGF1R is crucial for tumor transformation and survival of malignant cell.
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Related Signaling Pathways

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Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

MSDS

COA

Certificate of Analysis Lookup

To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.

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Isotype Control

Secondary Antibody

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