Human Anti-IGF1R (clone 7C10) scFv-Fc Chimera (CAT#: VS-0325-FY85)

• Host Species
• Human

• Type
• Human IgG1, scFv-Fc

• Specificity
• Human IGF1R

• Species Reactivity
• Human

• Clone
• 7C10

• Applications
• ELISA, Flow Cytometry, Inhibition

• Related Disease
• Cancer

• Purity
• >95% as determined by SDS-PAGE

• Concentration
• Please refer to the vial label for the specific concentration.

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

• Shipping
• Ice packs

• Alternative Names
• Insulin Like Growth Factor 1 Receptor

• Gene ID
• 3480

• UniProt ID
• P08069

• Long Name
• Insulin Like Growth Factor 1 Receptor

• Sequence Similarities
• Belongs to the protein kinase superfamily.

• Cellular Localization
• Cell membrane

• Post Translation Modifications
• Autophosphorylated on tyrosine residues in response to ligand binding.
  Autophosphorylation occurs in trans, i.e.
  one subunit of the dimeric receptor phosphorylates tyrosine residues on the other subunit.
  Autophosphorylation occurs in a sequential manner; Tyr-1165 is predominantly phosphorylated first, followed by phosphorylation of Tyr-1161 and Tyr-1166.

• Protein Refseq
• XP_011519818.1; XP_011519819.1; XP_016877626.1; XP_047288398.1; XP_047288399.1

• Function
• Receptor tyrosine kinase which mediates actions of insulin-like growth factor 1 (IGF1).
  Binds IGF1 with high affinity and IGF2 and insulin (INS) with a lower affinity.
  The activated IGF1R is involved in cell growth and survival control.
  IGF1R is crucial for tumor transformation and survival of malignant cell.

Isotype Control

• MOB-200CQ
• Human IgG Fc Isotype Control Antibody

Secondary Antibody

• 2ND-029CQ
• Goat Anti-Human IgG Fc Antibody

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