Afuco™ Anti-IGF1R ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-209)

Name: Afuco™ Anti-IGF1R ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-209)
SKU: AFC-TAB-209
Rating: 5 (1 reviews)

CAT#: AFC-TAB-209

This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant monoclonal antibody to IGF1 Receptor. It is a monoclonal antibody and an antineoplastic by Schering-Plough. It binds to CD221, the insulin-like growth factor 1 receptor.

Gene Expression

Normal Tissue Figure 1 Cerebral cortex

Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Glial cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Neuronal cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Neuropil
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10268/32662_B_7_5.jpg

Normal Tissue Figure 2 Colon

Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Glandular cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10268/32662_A_7_3.jpg

Normal Tissue Figure 3 Liver

Cholangiocytes
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Hepatocytes
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10268/32662_A_8_4.jpg

Normal Tissue Figure 4 Kidney

Cells in glomeruli
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Cells in tubules
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10268/32662_A_7_5.jpg

Normal Tissue Figure 5 Testis

Cells in seminiferous ducts
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Leydig cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10268/32662_A_6_6.jpg

Normal Tissue Figure 6 Heart muscle

Cardiomyocytes
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10268/32662_B_5_6.jpg

Normal Tissue Figure 7 Lymph node

Germinal center cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10268/32662_A_7_8.jpg

RNA Expression Figure 8 RNA cell line category: Low cell line specificity

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000140443-IGF1R

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Specifications

Immunogen
The details of the immunogen for this antibody are not available.

Host Species
Human

Derivation
Human

Type
ADCC enhanced antibody

Species Reactivity
Human

Applications
FuncS, IF, Neut, ELISA, FC, IP

Conjugate
Unconjugated

Generic Name
Robatumumab

Related Disease
Blood cancers

Product Property

Purity
>95% by SDS-PAGE

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Alternative Names
IGF1R; insulin-like growth factor 1 receptor; CD221; IGFIR; IGFR; JTK13; MGC18216; IGF-I receptor; soluble IGF1R variant 1; soluble IGF1R variant 2; insulin-like growth factor I receptor;

Gene ID
3480

UniProt ID
P08069

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Biosimilar Overview

Please refer to Robatumumab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Robatumumab.

Related Signaling Pathways

Insulin Signaling Pathway

Related Diseases

Endocrine Resistance

Type I Diabetes Mellitus

Downloadable Resources

Download resources about recombinant antibody development and antibody engineering to boost your research.

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

Datasheet - AFC-TAB-209.pdf

MSDS

MSDS - AFC-TAB-209.pdf

COA

Certificate of Analysis Lookup

To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.

Lot Number:

Protocol & Troubleshooting

Immunofluorescence (IF)

We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.

See other products for "Robatumumab"

DrugMonitor™ Anti-Robatumumab Antibody (VS-1224-YC1028)
Robatumumab is a monoclonal antibody with antineoplastic properties, studied in trials for conditions like osteosarcoma, Ewing's sarcoma, and peripheral neuroectodermal tumor. The DrugMonitor™ Anti-Robatumumab Antibody (VS-1224-YC1028) is an anti-drug antibody (ADA) against Robatumumab. This drug-based antibody is raised in mice immunized with the Robatumumab. The anti-Robatumumab antibody may be used in ELISA, pharmacokinetics (PK), and pharmacodynamics (PD) analyses, or serves as a reference standard in ADA assays. It also is an excellent tool for therapeutic drug monitoring, allowing to evaluate the drug efficacy and determine the drug concentration of the Robatumumab in samples.

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AFC-TAB-078	Afuco™ Anti-IGF1R ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-078)	IF, IP, Neut, FuncS, ELISA, FC	ADCC enhanced antibody
AFC-TAB-232	Afuco™ Anti-IGF1R ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-232)	IF, IP, Neut, FuncS, ELISA	ADCC enhanced antibody

CAT	Product Name	Application	Type
TAB-009ZJ	Mouse Anti-IGF1R Recombinant Antibody (TAB-009ZJ)	ELISA, FC	Mouse IgG1, κ
TAB-010ZJ	Anti-Human IGF-1R Recombinant Antibody (6E11)	ELISA, Neut, FC, IHC
TAB-011ZJ	Mouse Anti-IGF1R Recombinant Antibody (TAB-011ZJ)	ELISA, FC, WB, Inhib	Mouse IgG2, κ
TAB-012ZJ	Mouse Anti-IGF1R Recombinant Antibody (TAB-012ZJ)	ELISA, FC, WB, Inhib	Mouse IgG2, κ
TAB-013ZJ	Anti-Human IGF-1R Recombinant Antibody (1H7)	WB, Inhib

CAT	Product Name	Application	Type
TAB-052ZJ	Anti-Human IGF-1R Recombinant Antibody (TAB-052ZJ)	IHC, ELISA, FC, IF, IP	Human antibody
TAB-053ZJ	Anti-Human IGF-1R Recombinant Antibody (IR3)	ELISA, FC, WB	Human antibody
TAB-054ZJ	Anti-Human IGF-1R Recombinant Antibody (IR10)	ELISA, FC, WB	Human antibody
TAB-055ZJ	Human Anti-IGF1R Recombinant Antibody (TAB-055ZJ)	ELISA	Human IgG
TAB-056ZJ	Human Anti-IGF1R Recombinant Antibody (TAB-056ZJ)	FC, WB	Human IgG

CAT	Product Name	Application	Type
TAB-035ZJ-S(P)	Human Anti-IGF1R Recombinant Antibody; scFv Fragment (TAB-035ZJ-S(P))	ELISA, FC	Humanized scFv
TAB-036ZJ-S(P)	Anti-Human IGF-1R Recombinant Antibody scFv Fragment (H0L0 IgGIm(AA))	ELISA, Neut, FC, IHC	Humanized antibody
TAB-037ZJ-S(P)	Anti-Human IGF-1R Recombinant Antibody scFv Fragment (H1L0 IgGIm(AA))	ELISA, Neut, FC, IHC	Humanized antibody
TAB-038ZJ-S(P)	Human Anti-IGF1R Recombinant Antibody; scFv Fragment (TAB-038ZJ-S(P))	ELISA, FC, Inhib, IP	Humanized scFv
TAB-051ZJ-S(P)	Human Anti-IGF1R Recombinant Antibody; scFv Fragment (TAB-051ZJ-S(P))	ELISA, IHC, IF, WB	Human scFv

CAT	Product Name	Application	Type
TAB-084ZJ-F(E)	Human Anti-IGF1R Recombinant Antibody; Fab Fragment (TAB-084ZJ-F(E))	ELISA, FC	Chimeric (mouse/human) Fab
TAB-085ZJ-F(E)	Anti-Human IGF-1R Recombinant Antibody Fab Fragment (6E11c)	ELISA, Neut, FC, IHC	Chimeric antibody (mouse/human)
TAB-086ZJ-F(E)	Human Anti-IGF1R Recombinant Antibody; Fab Fragment (TAB-086ZJ-F(E))	ELISA, FC, Inhib, IP	Chimeric (mouse/human) Fab
TAB-087ZJ-F(E)	Anti-Human IGF-1R Recombinant Antibody Fab Fragment (ch7C2)	ELISA	Chimeric antibody (mouse/human)
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BRD-0103MZ	Chicken Anti-CD221 Polyclonal IgY	WB	Chicken antibody

CAT	Product Name	Application	Type
NEUT-1075CQ	Mouse Anti-IGF1R Recombinant Antibody (clone alphaIR3)	FC, IP, Neut, ICC, IF	Mouse IgG1
NEUT-1076CQ	Mouse Anti-IGF1R Recombinant Antibody (clone 33255.111)	ELISA, Neut, WB	Mouse IgG1
NEUT-1081CQ	Mouse Anti-IGF1R Recombinant Antibody (clone CBL453)	WB, ELISA, Neut	Mouse IgG1
NEUT-1082CQ	Mouse Anti-IGF1R Recombinant Antibody (clone CBL080)	Neut, WB	Mouse IgG1

CAT	Product Name	Application	Type
NEUT-1077CQ	Mouse Anti-IGF1R Recombinant Antibody (clone 1H7)	FC, Block, IHC, IP, WB	Mouse IgG1, κ
NEUT-1078CQ	Mouse Anti-IGF1R Recombinant Antibody (clone 24-60)	Inhib, ICC, IF, IP, WB	Mouse IgG2a, κ
NEUT-1079CQ	Mouse Anti-IGF1R Recombinant Antibody (clone 17-69)	Inhib, IP	Mouse IgG1
NEUT-1080CQ	Mouse Anti-IGF1R Recombinant Antibody (clone 24-57)	Inhib, IP	Mouse IgG1, κ

CAT	Product Name	Application	Type
MOR-1755	Rabbit Anti-IGF1R Recombinant Antibody (clone DS1755AB)	IP, ELISA	Rabbit IgG
MOR-4684	Rabbit Anti-IGF1R Recombinant Antibody (clone TH198DS)	WB, ELISA	Rabbit IgG
MOR-4685	Rabbit Anti-IGF1R Recombinant Antibody (clone TH199DS)	WB	Rabbit IgG

CAT	Product Name	Application	Type
HPAB-0084-YC-F(E)	Human Anti-IGF1R Recombinant Antibody; Fab Fragment (HPAB-0084-YC-F(E))	ELISA, FC	Humanized Fab
HPAB-0085-YC-F(E)	Human Anti-IGF1R Recombinant Antibody; Fab Fragment (HPAB-0085-YC-F(E))	Block, FuncS, FC, ELISA	Human Fab
HPAB-1204-FY-S(P)	Mouse Anti-IGF1R Recombinant Antibody (clone 2C6); Fab Fragment	Inhib, ELISA	Mouse Fab
HPAB-1205-FY-S(P)	Mouse Anti-IGF1R Recombinant Antibody (clone 9H2); Fab Fragment	Inhib, ELISA	Mouse Fab
HPAB-1206-FY-S(P)	Mouse Anti-IGF1R Recombinant Antibody (clone 6E11); Fab Fragment	ELISA	Mouse Fab

CAT	Product Name	Application	Type
NS-041CN	Mouse Anti-IGF1R Recombinant Antibody (NS-041CN)	ELISA, WB, FC	Mouse IgG
NS-041CN-F(E)	Mouse Anti-IGF1R Recombinant Antibody; Fab Fragment (NS-041CN-F(E))	ELISA, WB, FC	Mouse Fab
NS-041CN-S(P)	Mouse Anti-IGF1R Recombinant Antibody; scFv Fragment (NS-041CN-S(P))	ELISA, WB, FC	Mouse scFv

CAT	Product Name	Application	Type
HPAB-0210CQ	Human Anti-IGF1R Recombinant Antibody (clone 15H12)	ELISA, FC, Neut	Human IgG3, κ
HPAB-0211CQ	Human Anti-IGF1R Recombinant Antibody (clone 1H3)	ELISA, FC, Neut	Human IgG
HPAB-0212CQ	Human Anti-IGF1R Recombinant Antibody (clone 11A4)	ELISA, FC, Block	Human IgG1
HPAB-0213CQ	Human Anti-IGF1R Recombinant Antibody (clone 8A1)	ELISA, FC, Block	Human IgG1
HPAB-0214CQ	Human Anti-IGF1R Recombinant Antibody (clone PINT-9A2)	ELISA, FC, Block	Human IgG1

CAT	Product Name	Application	Type
HPAB-0210CQ-S(P)	Human Anti-IGF1R Recombinant Antibody (clone 15H12); scFv Fragment	ELISA, FC, Neut	Human scFv
HPAB-0211CQ-S(P)	Human Anti-IGF1R Recombinant Antibody (clone 1H3); scFv Fragment	ELISA, FC, Neut	Human scFv
HPAB-0212CQ-S(P)	Human Anti-IGF1R Recombinant Antibody (clone 11A4); scFv Fragment	ELISA, FC, Block	Human scFv
HPAB-0213CQ-S(P)	Human Anti-IGF1R Recombinant Antibody (clone 8A1); scFv Fragment	ELISA, FC, Block	Human scFv
HPAB-0214CQ-S(P)	Human Anti-IGF1R Recombinant Antibody (clone PINT-9A2); scFv Fragment	ELISA, FC, Block	Human scFv

CAT	Product Name	Application	Type
VS-0424-XY145	AbPlus™ Anti-IGF1R Magnetic Beads (9E11)	IP, Protein Purification

CAT	Product Name	Application	Type
VS-0125-FY20	Human Anti-IGF1R (clone 1H3) scFv-Fc Chimera	ELISA, FC, Neut, Inhib	Human IgG1, scFv-Fc
VS-0325-FY85	Human Anti-IGF1R (clone 7C10) scFv-Fc Chimera	ELISA, FC, Inhib	Human IgG1, scFv-Fc

CAT	Product Name	Application
VS-0325-XY1101	Anti-IGF1R Immunohistochemistry Kit	IHC
VS-0525-XY3431	Anti-Mouse IGF1R Immunohistochemistry Kit	IHC
VS-0525-XY3430	Anti-Human IGF1R Immunohistochemistry Kit	IHC
VS-0525-XY3432	Anti-Rat IGF1R Immunohistochemistry Kit	IHC

CAT	Product Name	Application	Type
VS-0425-YC366	Recombinant Anti-IGF1R Vesicular Antibody, EV Displayed (VS-0425-YC366)	ELISA, FC, Neut, Cell-uptake

CAT	Product Name	Application	Type
VS-0525-YC108	Recombinant Anti-IGF1R (AA 62-184 x AA 283-440) Biparatopic Antibody, Tandem scFv (Clone 4-52 x Clone 45742)	ELISA	Tandem scFv
VS-0525-YC107	Recombinant Anti-IGF1R (AA 283-440 x AA 440-514) Biparatopic Antibody, Tandem scFv (Clone 45742 x Clone 24-55)	ELISA	Tandem scFv

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