Recombinant Anti-IGF1R Vesicular Antibody, EV Displayed (VS-0425-YC366)

Name: Recombinant Anti-IGF1R Vesicular Antibody, EV Displayed (VS-0425-YC366)
SKU: VS-0425-YC366
Rating: 5 (1 reviews)

CAT#: VS-0425-YC366

The Recombinant Anti-IGF1R Vesicular Antibody, EV Displayed (VS-0425-YC366) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to IGF1R-expressed cells or tissues. The IGF1R is a receptor for insulin-like growth factors, which is critical for cell survival and transformation, overexpressed in malignancies.

Gene Expression

Normal Tissue Figure 1 Cerebral cortex

Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Glial cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Neuronal cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Neuropil
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10268/32662_B_7_5.jpg

Normal Tissue Figure 2 Colon

Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Glandular cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10268/32662_A_7_3.jpg

Normal Tissue Figure 3 Liver

Cholangiocytes
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Hepatocytes
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10268/32662_A_8_4.jpg

Normal Tissue Figure 4 Kidney

Cells in glomeruli
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Cells in tubules
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10268/32662_A_7_5.jpg

Normal Tissue Figure 5 Testis

Cells in seminiferous ducts
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Leydig cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10268/32662_A_6_6.jpg

Normal Tissue Figure 6 Heart muscle

Cardiomyocytes
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10268/32662_B_5_6.jpg

Normal Tissue Figure 7 Lymph node

Germinal center cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10268/32662_A_7_8.jpg

RNA Expression Figure 8 RNA cell line category: Low cell line specificity

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000140443-IGF1R

❮

❯

Recombinant Antibody

Application
ELISA, FC, Neut, Cell-uptake

Product Type
Ab-Fc-EVs

Antibody Quantification (Ab/EV)
~100 Ab/EV

Target
IGF1R

Host Animal
Mouse

Antibody Isotype
IgG1

Species Reactivity
Human

Expression Cell
Mammalian cell

Engineered EVs

EV-sorting domain
CD63

Fc-binding domain
Protein G

EV Size
30~150 nm

Producing Cell
HEK293F

Isolation Method
Gradient centrifugation

Purification
qEV size exclusion chromatography

Concentration
1 x 10¹⁰

Size
1 mL

Buffer
PBS

Storage
Store at -80°C for 12 months

Target

Full Name
Insulin like growth factor 1 receptor

Biological Process
Host-virus interaction

Molecular Function
Kinase, Receptor, Transferase, Tyrosine-protein kinase

Cellular Localization
Nucleoli rim, Plasma membrane, Nucleoli, Primary cilium

Introduction
This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014]

Alternative Names
CD221, IGFIR, IGFR, JTK13, MGC18216

Gene ID
3480

UniProt ID
P08069

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Related Signaling Pathways

Insulin Signaling Pathway

Related Diseases

Endocrine Resistance

Type I Diabetes Mellitus

Downloadable Resources

Download resources about recombinant antibody development and antibody engineering to boost your research.

Datasheet

Datasheet - VS-0425-YC366.pdf

MSDS

MSDS - VS-0425-YC366.pdf

COA

Certificate of Analysis Lookup

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TAB-009ZJ-S(P)	Mouse Anti-IGF1R Recombinant Antibody; scFv Fragment (TAB-009ZJ-S(P))	ELISA, FC	Mouse scFv
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CAT	Product Name	Application	Type
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CAT	Product Name	Application	Type
NEUT-1077CQ	Mouse Anti-IGF1R Recombinant Antibody (clone 1H7)	FC, Block, IHC, IP, WB	Mouse IgG1, κ
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NEUT-1079CQ	Mouse Anti-IGF1R Recombinant Antibody (clone 17-69)	Inhib, IP	Mouse IgG1
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CAT	Product Name	Application	Type
MOR-1755	Rabbit Anti-IGF1R Recombinant Antibody (clone DS1755AB)	IP, ELISA	Rabbit IgG
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HPAB-0084-YC	Human Anti-IGF1R Recombinant Antibody (HPAB-0084-YC)	ELISA, FC	Humanized IgG
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HPAB-0456-YJ	Human Anti-IGF1R Recombinant Antibody (clone DB#2)	ELISA, Inhib, FuncS	Human IgG1
HPAB-0457-YJ	Human Anti-IGF1R Recombinant Antibody (clone DB#7)	ELISA, Inhib, FuncS	Human IgG1
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NS-041CN-F(E)	Mouse Anti-IGF1R Recombinant Antibody; Fab Fragment (NS-041CN-F(E))	ELISA, WB, FC	Mouse Fab
NS-041CN-S(P)	Mouse Anti-IGF1R Recombinant Antibody; scFv Fragment (NS-041CN-S(P))	ELISA, WB, FC	Mouse scFv

CAT	Product Name	Application	Type
HPAB-0210CQ-F(E)	Human Anti-IGF1R Recombinant Antibody (clone 15H12); Fab Fragment	ELISA, FC, Neut	Human Fab
HPAB-0211CQ-F(E)	Human Anti-IGF1R Recombinant Antibody (clone 1H3); Fab Fragment	ELISA, FC, Neut	Human Fab
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AFC-TAB-736	Afuco™ Anti-IGF1R ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-736)	FC, IP, ELISA, Neut, FuncS, IF	ADCC enhanced antibody
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CAT	Product Name	Application	Type
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CAT	Product Name	Application
VS-0325-XY1101	Anti-IGF1R Immunohistochemistry Kit	IHC
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VS-0525-XY3430	Anti-Human IGF1R Immunohistochemistry Kit	IHC
VS-0525-XY3432	Anti-Rat IGF1R Immunohistochemistry Kit	IHC

CAT	Product Name	Application	Type
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