Recombinant Anti-IGF1R Vesicular Antibody, EV Displayed (VS-0425-YC366) (CAT#: VS-0425-YC366)

• Application
• ELISA, FC, Neut, Cell-uptake

• Product Type
• Ab-Fc-EVs

• Antibody Quantification (Ab/EV)
• ~100 Ab/EV

• Target
• IGF1R

• Host Animal
• Mouse

• Antibody Isotype
• IgG1

• Species Reactivity
• Human

• Expression Cell
• Mammalian cell

• EV-sorting domain
• CD63

• Fc-binding domain
• Protein G

• EV Size
• 30~150 nm

• Producing Cell
• HEK293F

• Isolation Method
• Gradient centrifugation

• Purification
• qEV size exclusion chromatography

• Concentration
• 1 x 10¹⁰

• Size
• 1 mL

• Buffer
• PBS

• Storage
• Store at -80°C for 12 months

• Full Name
• Insulin like growth factor 1 receptor

• Biological Process
• Host-virus interaction

• Molecular Function
• Kinase, Receptor, Transferase, Tyrosine-protein kinase

• Cellular Localization
• Nucleoli rim, Plasma membrane, Nucleoli, Primary cilium

• Introduction
• This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014]

• Alternative Names
• CD221, IGFIR, IGFR, JTK13, MGC18216

• Gene ID
• 3480

• UniProt ID
• P08069

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