Human Anti-IL2RA Recombinant Antibody Hexamer (VS-0924-YC133), CDC Enhanced

Name: Human Anti-IL2RA Recombinant Antibody Hexamer (VS-0924-YC133), CDC Enhanced
SKU: VS-0924-YC133
Rating: 5 (1 reviews)

CAT#: VS-0924-YC133

The product is a human anti-IL2RA antibody hexamer with enhanced CDC activity. This hexameric IgG1 targets human IL2RA and includes hexamerization-enhancing mutations. These mutations promote hexamer formation, which facilitates optimal C1q binding and boosts complement-dependent cytotoxicity (CDC).

Gene Expression

Normal Tissue Figure 1 Lymph node

Germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/54622/137874_A_8_8.jpg

Normal Tissue Figure 2 Tonsil

Non-germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/54622/137874_A_4_8.jpg

RNA Expression Figure 3 RNA cell line category: Cell line enriched (HDLM-2)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000134460-IL2RA

❮

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Specifications

Immunogen
Human T cells

Host Species
Human

Type
Antibody hexamer

Specificity
Human IL2RA

Species Reactivity
Human

Molecule Class
~ 900 kDa

Applications
CDC

Conjugate
None

Product Property

Clonality
Monoclonal

Purification
Protein A purified

Purity
>95% determined as SDS-PAGE and SEC-HPLC

Aggregation
<5%

Buffer
PBS, pH 7.4

Preservative
No preservatives

Storage
Store at 4°C short term (1-2 weeks). Store at -20°C long term (12 months). Avoid repeated freeze/thaw cycles.

Target

Alternative Names
Interleukin 2 Receptor Subunit Alpha

Gene ID
3559

UniProt ID
P01589

Long Name
Interleukin 2 Receptor Subunit Alpha

Cellular Localization
Membrane

Post Translation Modifications
Glycosylation at Asn70, Asn89, Thr218, Thr224, Thr229, and Thr237 (NX_P01589 [NX_P01589-1])
Modification sites at PhosphoSitePlus (P01589)
Glycosylation from GlyGen (P01589) 6 sites

Protein Refseq
NP_001295171.1; NP_000408.1

Function
Receptor for interleukin-2.
The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity.
TREGs suppress the activation and expansion of autoreactive T-cells.

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Datasheet

Datasheet - VS-0924-YC133.pdf

MSDS

MSDS - VS-0924-YC133.pdf

COA

Certificate of Analysis Lookup

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