Anti-Human CD25 Recombinant Antibody (Basiliximab) (CAT#: TAB-004)

Recombinant monoclonal antibody to Human CD25. Basiliximab (trade name Simulect) is a chimeric mouse-human monoclonal antibody to the α chain (CD25) of the IL-2 receptor of T cells. It is used to prevent rejection in organ transplantation, especially in kidney transplants. It is a chimeric CD25 monoclonal antibody of the IgG1 isotype. It acts as an antagonist at the interleukin-2(IL-2) binding site of the p55 subunit (Tac antigen) of the high affinity IL-2 receptor (CD25) on the surface of the activated T lymphocytes.

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Specifications

  • Immunogen
  • The details of the immunogen for this antibody are not available.
  • Host Species
  • Mouse
  • Derivation
  • Chimeric (mouse/human)
  • Type
  • IgG1 - kappa
  • Specificity
  • Tested positive against native human antigen
  • Species Reactivity
  • Human
  • Applications
  • Suitable for use in FC, IP, ELISA, Neut, FuncS, IF, WB and most other immunological methods.
  • Trade name
  • simulect
  • CAS
  • 152923-56-3
  • Generic Name
  • Basiliximab
  • Biological Half-Life
  • 7.2 days
  • ATC Code
  • L04AC02
  • DrugBank
  • DB00074
  • UNII
  • 9927MT646M
  • ChEMBL
  • CHEMBL1201439
  • MW
  • 143,801.3 g/mol
  • Related Disease
  • Kidney transplant rejection, acute

Product Property

  • Purity
  • Purity >95% by SDS-PAGE.
  • Storage
  • Store at 4°C for up to 3 months. For longer term storage aliquot into small volumes and store at -20°C.

Target

  • Alternative Names
  • Basiliximab;simulect;152923-56-3;SDZ CHII621;DB00074IL2RA;interleukin 2 receptor, alpha;IL2R;interleukin-2 receptor subunit alpha;CD25;p55;IL2-RA;IL-2-RA;TAC antigen;IL-2R subunit alpha;IL-2 receptor subunit alpha;TCGFR;IDDM10;

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "Basiliximab"

Afuco™ Anti-IL2RA ADCC Recombinant Antibody (Basiliximab), ADCC Enhanced
This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant monoclonal antibody to Human CD25. Basiliximab (trade name Simulect) is a chimeric mouse-human monoclonal antibody to the α chain (CD25) of the IL-2 receptor of T cells. It is used to prevent rejection in organ transplantation, especially in kidney transplants. It is a chimeric CD25 monoclonal antibody of the IgG1 isotype. It acts as an antagonist at the interleukin-2(IL-2) binding site of the p55 subunit (Tac antigen) of the high affinity IL-2 receptor (CD25) on the surface of the activated T lymphocytes.
DrugMonitor™ Anti-Basiliximab Antibody (VS-1224-YC163)
Basiliximab is a recombinant chimeric (murine/human) monoclonal antibody functioning as an immunosuppressant by binding to and blocking the IL-2R alpha on activated T-lymphocytes. The DrugMonitor™ Anti-Basiliximab Antibody (VS-1224-YC163) is an anti-drug antibody (ADA) against Basiliximab. This drug-based antibody is raised in mice immunized with the Basiliximab. The anti-Basiliximab antibody may be used in ELISA, pharmacokinetics (PK), and pharmacodynamics (PD) analyses, or serves as a reference standard in ADA assays. It also is an excellent tool for therapeutic drug monitoring, allowing to evaluate the drug efficacy and determine the drug concentration of the Basiliximab in samples.

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(Creative Biolabs Cat# TAB-004, RRID: AB_3111732)

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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