Recombinant Anti-human IL2RA Intrabody [Tat] (CAT#: IAB-B073(T))

• Immunogen
• human interleukin 2 receptor, alpha

• Host Species
• mouse

• Type
• scFv-Tat

• Cell Penetrating Peptide
• TAT
  TAT was able to deliver different proteins, such as horseradish peroxidase and RNase A across cell membrane into the cytoplasm in different cell lines in vitro. The size range of proteins with effective delivery is from 30kDa to 120-150kDa. In one study, TAT-fused proteins are rapidly internalized by lipid raft−dependent macropinocytosis using a transducible TAT−Cre recombinase reporter assay on live cells. In another study, a TAT-fused protein was delivered into mitochondria of breast cancer cells and decreased the survival of breast cancer cells, which showed capability of TAT-fusion proteins to modulate mitochondrial function and cell survival. However, very few in vivo studies have succeeded. In one study, in vivo delivery of TAT- or penetratin-crosslinked Fab fragments yielded varied organ distributions and an overall increase in organ retention, which showed tissue localization.

• Species Reactivity
• human

• Applications
• Antibody assay: Western blot; Coimmunopricipation; Functional studies

• Purity
• >90% assessed by SDS-PAGE

• Storage
• Short Term Storage: 4°C
  Long Term Storage: -20°C

• Alternative Names
• IL2RA; interleukin 2 receptor, alpha; p55; CD25; IL2R; TCGFR; IDDM10; interleukin-2 receptor subunit alpha; TAC antigen; IL-2R subunit alpha; IL-2 receptor subunit alpha

• Gene ID
• 3559

• UniProt ID
• P01589

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