Recombinant Anti-IL2RA Vesicular Antibody, EV Displayed (VS-0425-YC386)
CAT#: VS-0425-YC386
The Recombinant Anti-IL2RA Vesicular Antibody, EV Displayed (VS-0425-YC386) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to IL2RA-expressed cells or tissues. The IL2RA gene, part of the interleukin 2 receptor complex, modulates receptor affinity and exists in soluble forms due to cleavage, with mutations causing IL2 receptor alpha deficiency.
Gene Expression
Normal Tissue
Figure 1 Lymph node
Germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/54622/137874_A_8_8.jpg
Normal Tissue
Figure 2 Tonsil
Non-germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/54622/137874_A_4_8.jpg
RNA Expression
Figure 3 RNA cell line category: Cell line enriched (HDLM-2)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000134460-IL2RA
❮
❯
Recombinant Antibody
- Application
- ELISA, FC, Neut, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- IL2RA
- Host Animal
- Human
- Antibody Isotype
- IgG1 kappa
- Species Reactivity
- Human
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- z domain
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Binding Affinity
- Kd = 0.85 µg/mL
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Interleukin 2 receptor subunit alpha
- Biological Process
- Immunity
- Molecular Function
- Receptor
- Introduction
- The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency.[provided by RefSeq, Nov 2009]
- Alternative Names
- CD25, IDDM10, IL2R
- Gene ID
- 3559
- UniProt ID
- P01589
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Datasheet
MSDS
COA
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| TAB-641LC | Anti-human IL2RA Recombinant Antibody (TAB-641LC) | ELISA | |
| TAB-641LC-S(P) | Anti-human IL2RA scFv Fragment (TAB-641LC-S(P)) | ELISA | |
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| CAT | Product Name | Application | Type |
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| AGTO-L027R | anti-IL2RA immunotoxin RFT5 (scFv)-RTA | Cytotoxicity assay, Functional assay | |
| AGTO-L028E | anti-IL2RA immunotoxin RFT5 (IgG)-PE | Cytotoxicity assay, Functional assay | |
| AGTO-L028D | anti-IL2RA immunotoxin RFT5 (IgG)-DT | Cytotoxicity assay, Functional assay | |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABZ-082 | Human Anti-IL2RA Recombinant Antibody (clone SDZ CHI621) | Block | Chimeric (mouse/human) IgG |
| FAMAB-0197CQ | Mouse Anti-IL2RA Recombinant Antibody (clone 2C8) | ELISA, WB, FC | Mouse IgG1, κ |
| FAMAB-0198CQ | Human Anti-IL2RA Recombinant Antibody (clone 4C1) | ELISA, WB, FC | Chimeric (mouse/human) IgG1, κ |
| FAMAB-0199CQ | Mouse Anti-IL2RA Recombinant Antibody (clone 4F8) | ELISA, WB, FC | Mouse IgG2a, κ |
| FAMAB-0200CQ | Human Anti-IL2RA Recombinant Antibody (clone huD1) | ELISA, FC, Block | Humanized IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBL-608 | Human Anti-IL2RA Recombinant Antibody (clone RTF5); Fab Fragment | WB, FuncS | Chimeric (mouse/human) Fab |
| HPAB-0248CQ-F(E) | Mouse Anti-IL2RA Recombinant Antibody (clone 7G7/B6); Fab Fragment | DB, ICC | Mouse Fab |
| HPAB-M0454-YC-F(E) | Mouse Anti-IL2RA Recombinant Antibody; Fab Fragment (HPAB-M0454-YC-F(E)) | ELISA | Mouse Fab |
| HPAB-0559-WJ-F(E) | Human Anti-IL2RA Recombinant Antibody; Fab Fragment (HPAB-0559-WJ-F(E)) | ELISA, FC | Human Fab |
| HPAB-0560-WJ-F(E) | Human Anti-IL2RA Recombinant Antibody; Fab Fragment (HPAB-0560-WJ-F(E)) | ELISA, FC | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBL-608 | Mouse Anti-IL2RA Recombinant Antibody (clone RTF5); scFv Fragment | WB, FuncS | Mouse scFv |
| FAMAB-0197CQ-S(P) | Mouse Anti-IL2RA Recombinant Antibody (clone 2C8); scFv Fragment | ELISA, WB, FC | Mouse scFv |
| FAMAB-0198CQ-S(P) | Mouse Anti-IL2RA Recombinant Antibody (clone 4C1); scFv Fragment | ELISA, WB, FC | Mouse scFv |
| FAMAB-0199CQ-S(P) | Mouse Anti-IL2RA Recombinant Antibody (clone 4F8); scFv Fragment | ELISA, WB, FC | Mouse scFv |
| FAMAB-0200CQ-S(P) | Human Anti-IL2RA Recombinant Antibody (clone huD1); scFv Fragment | ELISA, FC, Block | Humanized scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-646LC | Anti-human IL2RA Recombinant Antibody (48M54S) (TAB-646LC) | FuncS | Humanized antibody |
| TAB-647LC | Anti-human IL2RA Recombinant Antibody (48M51L) (TAB-647LC) | FuncS | Humanized antibody |
| TAB-648LC | Anti-human IL2RA Recombinant Antibody (48V54S) (TAB-648LC) | FuncS | Humanized antibody |
| TAB-649LC | Anti-human IL2RA Recombinant Antibody (Dmab) (TAB-649LC) | FC | Humanized antibody |
| TAB-650LC | Human Anti-IL2RA Recombinant Antibody (TAB-650LC) | Block | Humanized IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-642LC-F(E) | Human Anti-IL2RA Recombinant Antibody; Fab Fragment (TAB-642LC-F(E)) | ELISA, FC | Human Fab |
| TAB-643LC-F(E) | Human Anti-IL2RA Recombinant Antibody; Fab Fragment (TAB-643LC-F(E)) | ELISA, FC | Human Fab |
| TAB-644LC-F(E) | Human Anti-IL2RA Recombinant Antibody; Fab Fragment (TAB-644LC-F(E)) | ELISA, FC | Human Fab |
| TAB-645LC-F(E) | Human Anti-IL2RA Recombinant Antibody; Fab Fragment (TAB-645LC-F(E)) | ELISA, FC | Human Fab |
| PABX-030-S (P) | Recombinant Mouse Anti-CD25 Antibody scFv Fragment (SDZCHII621) | Neut, FuncS | scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1344CQ | Mouse Anti-IL2RA Recombinant Antibody (clone B-B10) | FC, Neut, WB, IF | Mouse IgG1, κ |
| NEUT-1345CQ | Mouse Anti-IL2RA Recombinant Antibody (clone CBL017) | Neut, WB, IHC | Mouse IgG1 |
| NEUT-1346CQ | Mouse Anti-IL2RA Recombinant Antibody (clone CBL242) | ELISA, FC, Neut | Mouse IgG1, κ |
| NEUT-1348CQ | Mouse Anti-IL2RA Recombinant Antibody (clone CBL726) | WB, IHC, ICC, Neut | Mouse IgG1 |
| NEUT-1349CQ | Mouse Anti-IL2RA Recombinant Antibody (NEUT-1349CQ) | IHC, Neut, WB | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1350CQ | Mouse Anti-IL2RA Recombinant Antibody (NEUT-1350CQ) | Block, FC, ICC, IF, IHC, IP, WB | Mouse IgG1 |
| NEUT-1356CQ | Rat Anti-Il2ra Recombinant Antibody (VMC199) | FC, IP, IHC, Block, Depletion | Rat IgG1, λ |
| NEUT-1357CQ | Rat Anti-Il2ra Recombinant Antibody (clone 3C7) | FC, IP, Inhib | Rat IgG2b, κ |
| NEUT-1358CQ | Rat Anti-Il2ra Recombinant Antibody (NEUT-1358CQ) | Block, Depletion | Rat IgG1 |
| NEUT-1359CQ | Rat Anti-Il2ra Recombinant Antibody (NEUT-1359CQ) | Block, FC, IHC-Fr, IP | Rat IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1808 | Rabbit Anti-IL2RA Recombinant Antibody (clone DS1808AB) | IHC, ICC, IP | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-004 | Afuco™ Anti-IL2RA ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-004) | IF, IP, Neut, FuncS, ELISA, FC | ADCC enhanced antibody |
| AFC-TAB-023 | Afuco™ Anti-IL2RA ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-023) | ELISA, Neut, IF, IP, FC, FuncS | ADCC enhanced antibody |
| AFC-TAB-155 | Afuco™ Anti-IL2RA ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-155) | IP, IF, FuncS, FC, Neut, ELISA | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0424-XY150 | AbPlus™ Anti-IL2RA Magnetic Beads (2R12) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0924-YC133 | Human Anti-IL2RA Recombinant Antibody Hexamer (VS-0924-YC133), CDC Enhanced | CDC | Antibody hexamer |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0924-YC47 | Rabbit Anti-IL2RA Antibody (VS-0924-YC47) - Cancer Stem Cell Marker | IHC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
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| VS-0425-FY42 | Mouse Anti-IL2RA (clone mAb1) scFv-Fc Chimera | ELISA | Mouse IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0225-XY135 | CytoStream™ Mouse Anti-IL2RA Recombinant Antibody (clone BC96) | FC | Mouse IgG1, kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY3520 | Anti-IL2RA Immunohistochemistry Kit | IHC | |
| VS-0525-XY3521 | Anti-Mouse IL2RA Immunohistochemistry Kit | IHC | |
| VS-0525-XY3522 | Anti-Rat IL2RA Immunohistochemistry Kit | IHC |
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