Mouse Anti-IL2RA (clone mAb1) scFv-Fc Chimera

Name: Mouse Anti-IL2RA (clone mAb1) scFv-Fc Chimera
SKU: VS-0425-FY42
Rating: 5 (1 reviews)

CAT#: VS-0425-FY42

The anti-IL2R scFv-Fc is a specialized therapeutic agent that targets the interleukin-2 receptor (IL2R), crucial for T cell proliferation and immune regulation. This single-chain variable fragment fused with an Fc region provides enhanced binding affinity and pharmacokinetic properties, optimizing its effectiveness. By inhibiting the IL2R, this product aims to modulate T cell responses, making it particularly valuable in managing autoimmune disorders and preventing transplant rejection. Extensive preclinical evaluations indicate its potential to reduce hyperactive immune responses while preserving essential immune functions. Furthermore, its design allows for a more sustained action in the body, providing advantages over traditional therapeutic antibodies. The anti-IL2R scFv-Fc thus holds promise as a groundbreaking option for therapeutic intervention in immune-mediated diseases.

Gene Expression

Normal Tissue Figure 1 Lymph node

Germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/54622/137874_A_8_8.jpg

Normal Tissue Figure 2 Tonsil

Non-germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/54622/137874_A_4_8.jpg

RNA Expression Figure 3 RNA cell line category: Cell line enriched (HDLM-2)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000134460-IL2RA

❮

❯

Specifications

Host Species
Mouse

Type
Mouse IgG1, scFv-Fc

Specificity
Human IL2R

Species Reactivity
Human

Clone
mAb1

Applications
ELISA

Related Disease
Immunodeficiency 41 With Lymphoproliferation And Autoimmunity and Type 1 Diabetes Mellitus 10

Product Property

Purity
>95% as determined by SDS-PAGE

Concentration
Please refer to the vial label for the specific concentration.

Storage
Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Shipping
Ice packs

Applications

Application Notes
The optimal dilution concentration is determined by the experiment.

Target

Alternative Names
Interleukin 2 Receptor Subunit Alpha

Gene ID
3559

UniProt ID
P01589

Long Name
Interleukin 2 Receptor Subunit Alpha

Cellular Localization
Membrane

Post Translation Modifications
Glycosylation at Asn70, Asn89, Thr218, Thr224, Thr229, and Thr237
Modification sites at PhosphoSitePlus
Glycosylation from GlyGen 6 sites

Protein Refseq
NP_001295171.1; NP_000408.1

Function
Receptor for interleukin-2.
The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity.
TREGs suppress the activation and expansion of autoreactive T-cells.

REVIEWS AND Q&AS CITATIONS RESOURCES DOWNLOADS RELATED PRODUCTS

Inquiry

Navs

Customer Review

There are currently no Customer reviews or questions for VS-0425-FY42. Click the button above to contact us or submit your feedback about this product.

Submit Your Publication

Published with our product? Submit your paper and receive a 10% discount on your next order! Share your research to earn exclusive rewards.

Downloadable Resources

Download resources about recombinant antibody development and antibody engineering to boost your research.

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

Datasheet - VS-0425-FY42.pdf

MSDS

MSDS - VS-0425-FY42.pdf

COA

Certificate of Analysis Lookup

To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.

Lot Number:

See other products for "IL2RA"

Select a product category from the dropdown menu below to view related products.

CAT	Product Name	Application	Type
IAB-B073(A)	Recombinant Anti-human IL2RA Intrabody [(D-Arg)₉]	IF, ELISA, FuncS	scFv-(D-Arg)₉
IAB-B073(G)	Recombinant Anti-human IL2RA Intrabody [+36 GFP]	IF, FC, WB, FuncS	scFv-(+36GFP)
IAB-B073(T)	Recombinant Anti-human IL2RA Intrabody [Tat]	WB, CO-IP, FuncS	scFv-Tat

CAT	Product Name	Application	Type
TAB-004	Anti-Human CD25 Recombinant Antibody (Basiliximab)	IF, IP, Neut, FuncS, ELISA, FC, ICC	IgG1 - kappa
PABX-030	Recombinant Human Anti-CD25 Antibody (SDZCHII621)	Neut, FuncS	IgG
PABX-030-F (E)	Recombinant Mouse Anti-CD25 Antibody Fab Fragment (SDZCHII621)	Neut, FuncS	Fab

CAT	Product Name	Application	Type
TAB-155	Anti-Human CD25 Recombinant Antibody (TAB-155)	IP, IF, FuncS, FC, Neut, ELISA, ICC	IgG1 - kappa
TAB-641LC	Anti-human IL2RA Recombinant Antibody (TAB-641LC)	ELISA
TAB-641LC-S(P)	Anti-human IL2RA scFv Fragment (TAB-641LC-S(P))	ELISA
TAB-641LC-F(E)	Anti-human IL2RA Fab Fragment (TAB-641LC-F(E))	ELISA
PABX-029-S (P)	Recombinant Human Anti-CD25 Antibody scFv Fragment (Daclizumab)	WB, ELISA, FuncS	scFv

CAT	Product Name	Application
AGTO-L027D	anti-IL2RA immunotoxin RFT5 (scFv)-DT	Cytotoxicity assay, Functional assay
AGTO-L027R	anti-IL2RA immunotoxin RFT5 (scFv)-RTA	Cytotoxicity assay, Functional assay
AGTO-L078E	IL2-PE immunotoxin	Cytotoxicity assay, Functional assay
AGTO-L078D	IL2-DT immunotoxin	Cytotoxicity assay, Functional assay
AGTO-L078R	IL2-RTA immunotoxin	Cytotoxicity assay, Functional assay

CAT	Product Name	Application	Type
PABZ-020	Human Anti-IL2RA Recombinant Antibody (clone CHI621)	Block	Chimeric (mouse/human) IgG
HPAB-0248CQ	Mouse Anti-IL2RA Recombinant Antibody (clone 7G7/B6)	DB, ICC	Mouse IgG2a
HPAB-M0454-YC	Mouse Anti-IL2RA Recombinant Antibody (HPAB-M0454-YC)	ELISA	Mouse IgG2a, κ
VS3-XY858	Mouse Anti-IL2RA Recombinant Antibody, FITC (clone 4A7G7B6)	FC, IF	Mouse IgG2a
VS3-XY859	Mouse Anti-IL2RA Recombinant Antibody, PE-Cy5 (clone 4A7G7B6)	FC, IF	Mouse IgG2a

CAT	Product Name	Application	Type
PFBZ-020	Human Anti-IL2RA Recombinant Antibody (clone CHI621); Fab Fragment	Block	Chimeric (mouse/human) Fab
FAMAB-0197CQ-F(E)	Mouse Anti-IL2RA Recombinant Antibody (clone 2C8); Fab Fragment	ELISA, WB, FC	Mouse Fab
FAMAB-0198CQ-F(E)	Human Anti-IL2RA Recombinant Antibody (clone 4C1); Fab Fragment	ELISA, WB, FC	Chimeric (mouse/human) Fab
FAMAB-0199CQ-F(E)	Mouse Anti-IL2RA Recombinant Antibody (clone 4F8); Fab Fragment	ELISA, WB, FC	Mouse Fab
FAMAB-0200CQ-F(E)	Human Anti-IL2RA Recombinant Antibody (clone huD1); Fab Fragment	ELISA, FC, Block	Humanized Fab

CAT	Product Name	Application	Type
PSBL-608	Mouse Anti-IL2RA Recombinant Antibody (clone RTF5); scFv Fragment	WB, FuncS	Mouse scFv
HPAB-M0454-YC-S(P)	Mouse Anti-IL2RA Recombinant Antibody; scFv Fragment (HPAB-M0454-YC-S(P))	ELISA	Mouse scFv
HPAB-0559-WJ-S(P)	Human Anti-IL2RA Recombinant Antibody; scFv Fragment (HPAB-0559-WJ-S(P))	ELISA, FC	Human scFv
HPAB-0560-WJ-S(P)	Human Anti-IL2RA Recombinant Antibody; scFv Fragment (HPAB-0560-WJ-S(P))	ELISA, FC	Human scFv
HPAB-0561-WJ-S(P)	Human Anti-IL2RA Recombinant Antibody; scFv Fragment (HPAB-0561-WJ-S(P))	ELISA, FC	Human scFv

CAT	Product Name	Application	Type
TAB-642LC	Human Anti-IL2RA Recombinant Antibody (TAB-642LC)	ELISA, FC, Inhib	Human IgG1, κ
TAB-643LC	Human Anti-IL2RA Recombinant Antibody (TAB-643LC)	ELISA, FC, Inhib	Human IgG1, κ
TAB-644LC	Human Anti-IL2RA Recombinant Antibody (TAB-644LC)	ELISA, FC, Inhib	Human IgG1, κ
TAB-645LC	Human Anti-IL2RA Recombinant Antibody (TAB-645LC)	ELISA, FC, Inhib	Human IgG1, κ
PABX-029-F (E)	Recombinant Human Anti-CD25 Antibody Fab Fragment (Daclizumab)	WB, ELISA, FuncS	Fab

CAT	Product Name	Application	Type
TAB-646LC-S(P)	Anti-human IL2RA scFv Fragment (48M54S)	ELISA, FC	Humanized antibody
TAB-647LC-S(P)	Anti-human IL2RA scFv Fragment (48M51L)	ELISA, FC	Humanized antibody
TAB-648LC-S(P)	Anti-human IL2RA scFv Fragment (48V54S)	ELISA, FC	Humanized antibody
TAB-649LC-S(P)	Anti-human IL2RA scFv Fragment (Dmab)	FC	Humanized antibody
TAB-650LC-S(P)	Human Anti-IL2RA Recombinant Antibody; scFv Fragment (TAB-650LC-S(P))	ELISA	Humanized scFv

CAT	Product Name	Application	Type
NEUT-1344CQ	Mouse Anti-IL2RA Recombinant Antibody (clone B-B10)	FC, Neut, WB, IF	Mouse IgG1, κ
NEUT-1345CQ	Mouse Anti-IL2RA Recombinant Antibody (clone CBL017)	Neut, WB, IHC	Mouse IgG1
NEUT-1346CQ	Mouse Anti-IL2RA Recombinant Antibody (clone CBL242)	ELISA, FC, Neut	Mouse IgG1, κ
NEUT-1348CQ	Mouse Anti-IL2RA Recombinant Antibody (clone CBL726)	WB, IHC, ICC, Neut	Mouse IgG1
NEUT-1349CQ	Mouse Anti-IL2RA Recombinant Antibody (NEUT-1349CQ)	IHC, Neut, WB	Mouse IgG1

CAT	Product Name	Application	Type
NEUT-1350CQ	Mouse Anti-IL2RA Recombinant Antibody (NEUT-1350CQ)	Block, FC, ICC, IF, IHC, IP, WB	Mouse IgG1
NEUT-1356CQ	Rat Anti-Il2ra Recombinant Antibody (VMC199)	FC, IP, IHC, Block, Depletion	Rat IgG1, λ
NEUT-1357CQ	Rat Anti-Il2ra Recombinant Antibody (clone 3C7)	FC, IP, Inhib	Rat IgG2b, κ
NEUT-1358CQ	Rat Anti-Il2ra Recombinant Antibody (NEUT-1358CQ)	Block, Depletion	Rat IgG1
NEUT-1359CQ	Rat Anti-Il2ra Recombinant Antibody (NEUT-1359CQ)	Block, FC, IHC-Fr, IP	Rat IgG1

CAT	Product Name	Application	Type
MOR-1808	Rabbit Anti-IL2RA Recombinant Antibody (clone DS1808AB)	IHC, ICC, IP	Rabbit IgG

CAT	Product Name	Application	Type
AFC-TAB-004	Afuco™ Anti-IL2RA ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-004)	IF, IP, Neut, FuncS, ELISA, FC	ADCC enhanced antibody
AFC-TAB-023	Afuco™ Anti-IL2RA ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-023)	ELISA, Neut, IF, IP, FC, FuncS	ADCC enhanced antibody
AFC-TAB-155	Afuco™ Anti-IL2RA ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-155)	IP, IF, FuncS, FC, Neut, ELISA	ADCC enhanced antibody

CAT	Product Name	Application	Type
VS-0424-XY150	AbPlus™ Anti-IL2RA Magnetic Beads (2R12)	IP, Protein Purification

CAT	Product Name	Application	Type
VS-0924-YC133	Human Anti-IL2RA Recombinant Antibody Hexamer (VS-0924-YC133), CDC Enhanced	CDC	Antibody hexamer

CAT	Product Name	Application	Type
VS-0924-YC47	Rabbit Anti-IL2RA Antibody (VS-0924-YC47) - Cancer Stem Cell Marker	IHC	Rabbit IgG

CAT	Product Name	Application	Type
VS-0125-FY44	Human Anti-IL2RA (clone MAK179) scFv-Fc Chimera	Inhib	Human IgG1, scFv-Fc

CAT	Product Name	Application	Type
VS-0225-XY135	CytoStream™ Mouse Anti-IL2RA Recombinant Antibody (clone BC96)	FC	Mouse IgG1, kappa

CAT	Product Name	Application	Type
VS-0425-YC386	Recombinant Anti-IL2RA Vesicular Antibody, EV Displayed (VS-0425-YC386)	ELISA, FC, Neut, Cell-uptake

CAT	Product Name	Application
VS-0525-XY3520	Anti-IL2RA Immunohistochemistry Kit	IHC
VS-0525-XY3521	Anti-Mouse IL2RA Immunohistochemistry Kit	IHC
VS-0525-XY3522	Anti-Rat IL2RA Immunohistochemistry Kit	IHC

Specific Inquiry

Size:

Conjugation:

Endotoxin:

Purity:

Formats:

Isotype Switching:

Fc Engineering:

Modalities:

Add to compare

Request
Custom Production

See Our Custom Production in Action

Figure 1 Anti-HBV Recombinant Antibody (TAB-147) in SDS-PAGE

Download the full case study

Popular Products

Figure 1 Recombinant Anti-5-FU Antibody (MOB-12) in ELISA

Recombinant Anti-5-FU Antibody (CAT# MOB-12)
Application: WB, Neut, FuncS

Figure 2 Anti-SDC1 Antibody (TAB-197) in ELISA

Chimeric (Mouse/Human) Anti-SDC1 Recombinant Antibody (TAB-197) (CAT# TAB-197)
Application: Neut, ELISA, IF, IP, FuncS, FC, ICC

Figure 1 Anti-Human IL17RA Recombinant Antibody (TAB-217) in SDS-PAGE

Anti-Human IL17RA Recombinant Antibody (TAB-217) (CAT# TAB-217)
Application: WB, ELISA, FC, IP, FuncS, IF, Neut

Figure 10 Blockade of PD-1/PD-L1 interaction by anti-PD-1 antibody (Cat# TAB-770) resulted in an increase of IFN-γ production.

Anti-PDCD1 Recombinant Antibody (TAB-770) (CAT# TAB-770)
Application: IF, IP, Neut, FuncS, ELISA, FC, ICC

Figure 2 Anti-Human MET Recombinant Antibody (TAB-521CL) in WB

Anti-Human MET Recombinant Antibody (TAB-521CL) (CAT# TAB-521CL)
Application: WB, FuncS

Figure 2 Mouse Anti-GM3 Recombinant Antibody (PABC-051) in HPLC

Mouse Anti-GM3 Recombinant Antibody (clone 14F7) (CAT# PABC-051)
Application: ELISA

Figure 2 Anti-LPA Recombinant Antibody (TAB-0340CL) in HPLC

Anti-LPA Recombinant Antibody (LT3015 [B7(LT3000, Lpathomab)]) (CAT# TAB-0340CL)
Application: ELISA, SPR, Inhib, FuncS

Figure 4 Anti-Human CEACAM5 Recombinant Antibody (TAB-408LC) in ELISA

Anti-Human CEACAM5 Recombinant Antibody (A5B7) (CAT# TAB-408LC)
Application:

Figure 2 Anti-FGFR2 Recombinant Antibody (TAB-055WM) in HPLC

Anti-Human FGFR2 Recombinant Antibody (GP369/4B9) (CAT# TAB-055WM)
Application: FC

Figure 8 Anti-IAV HA Recombinant Antibody (MRO-276CT) in DB

Anti-IAV HA Recombinant Antibody (12D1) (CAT# MRO-276CT)
Application: ELISA, WB, Neut, Funcs, IHC, Inhib

Figure 3 Human Anti-Human ERBB3 Antibody (TAB-422CQ) in DB

Anti-Human ERBB3 Recombinant Antibody (TAB-422CQ) (CAT# TAB-422CQ)
Application: ELISA, IHC, FC, IP, IF, BL

Figure 2 Human CRCP Recombinant Antibody (TAB-426CQ) in HPLC

Human Anti-CRCP Recombinant Antibody (TAB-426CQ) (CAT# TAB-426CQ)
Application: ELISA, IHC, FC, IP, IF, Inhib

Figure 2 Recombinant Mouse Anti-HSPA1A Antibody (HPAB-0243-YC) in HPLC

Mouse Anti-HSPA1A Recombinant Antibody (HPAB-0243-YC) (CAT# HPAB-0243-YC)
Application: ELISA, FC

Figure 2 Human Anti-CD70 Recombinant Antibody (HPAB-0102-LSX) in HPLC

Human Anti-CD70 Recombinant Antibody (HPAB-0102-LSX) (CAT# HPAB-0102-LSX)
Application: ELISA, FuncS

Figure 2 Recombinant Human Anti-C. botulinum A str. Hall botA Antibody (S25 chimera) (EPAF-0119CQ) in WB

Recombinant Human Anti-C. botulinum A str. Hall botA Antibody (S25 chimera) (CAT# EPAF-0119CQ)
Application: ELISA, Neut

Figure 2 Mouse Anti-MRC2 Recombinant Antibody (HPAB-M0693-YC) in HPLC

Mouse Anti-MRC2 Recombinant Antibody (HPAB-M0693-YC) (CAT# HPAB-M0693-YC)
Application: WB, FuncS

Figure 2 Human Anti-HIV-1 gp120 Recombinant Antibody; Fab Fragment (PABX-098-F(E)) in HPLC

Human Anti-HIV-1 gp120 Recombinant Antibody Fab Fragment (PABX-098-F(E)) (CAT# PABX-098-F(E))
Application: WB, ELISA, FuncS

Figure 2 Human Anti-EBV gB Recombinant Antibody (Clone AMMO4) (PABS-0039) in WB

Human Anti-EBV gB Recombinant Antibody (Clone AMMO4) (CAT# PABS-0039)
Application: ELISA, FuncS

Figure 3 Human Anti-SIRPA Antibody (PABJ-0084) in DB

Human Anti-SIRPA Recombinant Antibody (PABJ-0084) (CAT# PABJ-0084)
Application: ELISA, Block

Figure 2 Anti-FAP Antibody in ELISA.

Mouse Anti-FAP Recombinant Antibody (clone F19) (CAT# HPAB-A1368-YJ)
Application: ELISA, FuncS, RIA, IP, IF, IHC, IA, Block

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

Send Inquiry

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.