Mouse Anti-IL2RA (clone mAb1) scFv-Fc Chimera
CAT#: VS-0425-FY42
The anti-IL2R scFv-Fc is a specialized therapeutic agent that targets the interleukin-2 receptor (IL2R), crucial for T cell proliferation and immune regulation. This single-chain variable fragment fused with an Fc region provides enhanced binding affinity and pharmacokinetic properties, optimizing its effectiveness. By inhibiting the IL2R, this product aims to modulate T cell responses, making it particularly valuable in managing autoimmune disorders and preventing transplant rejection. Extensive preclinical evaluations indicate its potential to reduce hyperactive immune responses while preserving essential immune functions. Furthermore, its design allows for a more sustained action in the body, providing advantages over traditional therapeutic antibodies. The anti-IL2R scFv-Fc thus holds promise as a groundbreaking option for therapeutic intervention in immune-mediated diseases.
Gene Expression
Normal Tissue
Figure 1 Lymph node
Germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/54622/137874_A_8_8.jpg
Normal Tissue
Figure 2 Tonsil
Non-germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/54622/137874_A_4_8.jpg
RNA Expression
Figure 3 RNA cell line category: Cell line enriched (HDLM-2)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000134460-IL2RA
❮
❯
Specifications
- Host Species
- Mouse
- Type
- Mouse IgG1, scFv-Fc
- Antibody Isotype
- scFv-Fc
- Specificity
- Human IL2R
- Species Reactivity
- Human
- Clone
- mAb1
- Applications
- ELISA
- Related Disease
- Immunodeficiency 41 With Lymphoproliferation And Autoimmunity and Type 1 Diabetes Mellitus 10
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- The optimal dilution concentration is determined by the experiment.
Target
- Alternative Names
- Interleukin 2 Receptor Subunit Alpha
- Gene ID
- 3559
- UniProt ID
- P01589
- Long Name
- Interleukin 2 Receptor Subunit Alpha
- Cellular Localization
- Membrane
- Post Translation Modifications
- Glycosylation at Asn70, Asn89, Thr218, Thr224, Thr229, and Thr237
Modification sites at PhosphoSitePlus
Glycosylation from GlyGen 6 sites
- Protein Refseq
- NP_001295171.1; NP_000408.1
- Function
- Receptor for interleukin-2.
The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity.
TREGs suppress the activation and expansion of autoreactive T-cells.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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