Mouse Anti-IL2RA (clone mAb1) scFv-Fc Chimera (CAT#: VS-0425-FY42)
The anti-IL2R scFv-Fc is a specialized therapeutic agent that targets the interleukin-2 receptor (IL2R), crucial for T cell proliferation and immune regulation. This single-chain variable fragment fused with an Fc region provides enhanced binding affinity and pharmacokinetic properties, optimizing its effectiveness. By inhibiting the IL2R, this product aims to modulate T cell responses, making it particularly valuable in managing autoimmune disorders and preventing transplant rejection. Extensive preclinical evaluations indicate its potential to reduce hyperactive immune responses while preserving essential immune functions. Furthermore, its design allows for a more sustained action in the body, providing advantages over traditional therapeutic antibodies. The anti-IL2R scFv-Fc thus holds promise as a groundbreaking option for therapeutic intervention in immune-mediated diseases.
Specific Inquiry
Custom Production
We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.
We require custom production
Normal Tissue
RNA Expression
Figure 1 Lymph node
(Germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/54622/137874_A_8_8.jpg
(Germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/54622/137874_A_8_8.jpg
Figure 2 Tonsil
(Non-germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/54622/137874_A_4_8.jpg
(Non-germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/54622/137874_A_4_8.jpg
Figure 3 RNA cell line category: Cell line enriched (HDLM-2)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000134460-IL2RA
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000134460-IL2RA
Figure 3 RNA cell line category: Cell line enriched (HDLM-2)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000134460-IL2RA
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000134460-IL2RA
Specifications
- Host Species
- Mouse
- Type
- Mouse IgG1, scFv-Fc
- Specificity
- Human IL2R
- Species Reactivity
- Human
- Clone
- mAb1
- Applications
- ELISA
- Related Disease
- Immunodeficiency 41 With Lymphoproliferation And Autoimmunity and Type 1 Diabetes Mellitus 10
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- The optimal dilution concentration is determined by the experiment.
Target
- Alternative Names
- Interleukin 2 Receptor Subunit Alpha
- Gene ID
- 3559
- UniProt ID
- P01589
- Long Name
- Interleukin 2 Receptor Subunit Alpha
- Cellular Localization
- Membrane
- Post Translation Modifications
- Glycosylation at Asn70, Asn89, Thr218, Thr224, Thr229, and Thr237
Modification sites at PhosphoSitePlus
Glycosylation from GlyGen 6 sites
- Protein Refseq
- NP_001295171.1; NP_000408.1
- Function
- Receptor for interleukin-2.
The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity.
TREGs suppress the activation and expansion of autoreactive T-cells.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "IL2RA"
Select a product category from the dropdown menu below to view related products.
Please select product type
IgG Antibody Products
Intrabody Products
Chimeric Antibody Products
Mouse Antibody Products
Immunotoxin Products
Fab Antibody Products
Human Antibody Products
Humanized Antibody Products
Neutralizing Antibody Products
Blocking Antibody Products
Rabbit Monoclonal Antibody Products
ScFv Antibody Products
ADCC Enhanced Antibody Products
Antibody Magnetic Beads
Hexamer Antibody Products
Cancer Stem Cell Biomarker Specific Antibody Products
ScFv-Fc Chimera Products
Flow Cytometry (FC) related Reagents and Kits: Empowering Cell Function Research
Extracellular Vesicle (EV) Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1094z | Mouse Anti-IL2RA Recombinant Antibody (clone 18C9) | WB, ELISA, IF, IHC, FuncS | Mouse IgG1, κ |
| PABL-613 | Human Anti-IL2RA Recombinant Antibody (clone RTF5) | WB, FuncS | Chimeric (mouse/human) IgG |
| HPAB-0060-FY | Human Anti-IL2RA Recombinant Antibody (HPAB-0060-FY) | ELISA, PD | Humanized IgG1, κ |
| HPAB-0197-FY | Mouse Anti-IL2RA Recombinant Antibody (clone WuTac) | FC, DB, WB | Mouse IgG |
| VS3-WK1456 | Mouse Anti-IL2RA Recombinant Antibody (clone 776) | FC, IF | Mouse IgG2a |
Customer Reviews and Q&As
There are currently no Customer reviews or questions for VS-0425-FY42. Click the button above to contact us or submit your feedback about this product.
Popular products with customers
Application: FC, IP, ELISA, Neut, FuncS, IF, ICC
Application: ELISA, FC, IP, FuncS, IF, Neut, ICC
Application: Neut, ELISA, IF, IP, FuncS, FC, ICC
Application: WB, ELISA, FC, IP, FuncS, IF, Neut
Application: ELISA, IHC, FC, IP, IF, FuncS
-1.png)
Application: ELISA
Application: ELISA, WB, Microarray, Block
Application: ELISA, FuncS
For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
