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anti-IL2RA immunotoxin RFT5 (IgG)-DT (AGTO-L028D)

This immunotoxin was achieved by conjugating/fusing the Anti-IL2RA monoclonal antibody to Diphtheriatoxin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to Hodgkin's lymphoma cells. Once bind, the toxin enters cells by receptor-mediated endocytosis, then Before the N-terminal 193 amino acids corresponding to the catalytic domain of DT enzyme; -II binding and elongation factor into the eukaryotic cell; the cell can catalyze specific elongation factor EF2 amide His699 of diphtheria ADP2 ribosylation occurs; thereby preventing protein synthesis and causes cell death. It was designed for treatment of Hodgkin's lymphoma.      
  • Datasheet

Specifications
Host
Mouse
Species Reactivity
Human
Clone
RFT5
Molecule Class
L kappa; IgG1-DT
Toxin Description
Diphtheria toxin (Diphtheriatoxin, DT) is a cell toxin produced by diphtheria, is a protein toxin most commonly used in the construction of recombinant immunotoxin. Before the N-terminal 193 amino acids corresponding to the catalytic domain of DT enzyme, -II binding and elongation factor into the eukaryotic cell, the cell can catalyze specific elongation factor EF2 amide His699 of diphtheria ADP2 ribosylation occurs, thereby preventing protein synthesis and causes cell death.
Applications
This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
Related Disease
Hodgkin's lymphoma
Target
Alternative Names
IL2RA; interleukin 2 receptor, alpha; p55; CD25; IL2R; TCGFR; IDDM10; interleukin-2 receptor subunit alpha
Entrez Gene ID
3559
UniProt ID
P01589

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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