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  • Afuco™ Anti-MUC1 ADCC Recombinant Antibody (Pemtumomab), ADCC Enhanced

Afuco™ Anti-MUC1 ADCC Recombinant Antibody (Pemtumomab), ADCC Enhanced (CAT#: AFC-TAB-H56)

This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant Mouse antibody to Human MUC1. Pemtumomab (trade name Theragyn) is a mouse monoclonal antibody used to treat cancer. The substance has affinity to various types of cancer, like ovarian cancer and peritoneal cancer, via the polymorphic epithelial mucin (PEM or MUC-1) and delivers the radioisotope Yttrium-90 into the tumour.


See more Engineered Antibody products for MUC1
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Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line RPTEC TERT1
Figure 1 IF staining of human cell line RPTEC TERT1
(Immunofluorescent staining of human cell line RPTEC TERT1 shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/8855/1789_B9_13_cr596f381e20667_selected.jpg
Figure 2 IHC staining of human stomach
Figure 2 IHC staining of human stomach
(Immunohistochemical staining of human stomach shows strong membranous positivity in glandular cells.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1986/ihc_selected.jpg
Figure 3 IF staining of human cell line A-431
Figure 3 IF staining of human cell line A-431
(Immunofluorescent staining of human cell line A-431 shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/8855/100_E7_1_blue_red_green.jpg
Figure 4 IF staining of human cell line U-2 OS
Figure 4 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/8855/101_E7_1_blue_red_green.jpg
Normal Tissue
Figure 5 Stomach
Figure 5 Stomach
(Glandular cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/36/155175_A_2_1.jpg
Figure 6 Colon
Figure 6 Colon
(Endocrine cells
Staining:High
Intensity: Strong
Enterocytes
Staining:High
Intensity: Strong
Quantity: 75%-25%
Goblet cells
Staining:High
Intensity: Strong
Quantity:>75%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/36/155175_A_9_3.jpg
Figure 7 Kidney
Figure 7 Kidney
(Collecting ducts
Staining:High
Intensity: Strong
Quantity:>75%
Distal tubules
Staining:High
Intensity: Strong
Quantity:>75%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/36/155175_A_8_5.jpg
Figure 8 Testis
Figure 8 Testis
(Elongated or late spermatids
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/36/155175_A_6_6.jpg
RNA Expression
Figure 9 RNA cell line category: Group enriched (CAPAN-2, OE19, RPTEC TERT1, T-47d)
Figure 9 RNA cell line category: Group enriched (CAPAN-2, OE19, RPTEC TERT1, T-47d)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000185499-MUC1

Specifications

  • Host Species
  • Mouse
  • Derivation
  • Mouse
  • Type
  • ADCC enhanced antibody
  • Species Reactivity
  • Human
  • Clone
  • Pemtumomab
  • Applications
  • FuncS, IF, Neut, ELISA, FC
  • Conjugate
  • Unconjugated
  • Trade name
  • Theragyn
  • Generic Name
  • Pemtumomab

Product Property

  • Purity
  • >95% by SDS-PAGE
  • Storage
  • Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

  • Alternative Names
  • Pemtumomab; Theragyn; HMFG1; Theragyn; MUC1; mucin 1, cell surface associated; mucin 1, transmembrane, PUM; mucin-1; CD227; PEM; episialin; DF3 antigen; H23 antigen; krebs von den Lungen-6; mucin 1, transmembrane; tumor-associated mucin; carcinoma-associated mucin

Related Resources

  • Biosimilar Overview
Please refer to Pemtumomab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Pemtumomab.

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "pemtumomab"

Anti-Human MUC1 Recombinant Antibody (Pemtumomab)
Recombinant Mouse antibody to Human MUC1. Pemtumomab (trade name Theragyn) is a mouse monoclonal antibody used to treat cancer. The substance has affinity to various types of cancer, like ovarian cancer and peritoneal cancer, via the polymorphic epithelial mucin (PEM or MUC-1) and delivers the radioisotope Yttrium-90 into the tumour.

See other products for "MUC1"

Single-domain Antibody

CAT Product Name Application Type
NAB-2049-VHH Recombinant Anti-human MUC1 VHH Single Domain Antibody WB, IP, ChiP, Neut, ELISA Llama VHH
HPAB-AP504-YC Recombinant Camel Anti-MUC1 Single Domain Antibody (5-24) FC Camel VHH
HPAB-AP505-YC Recombinant Camel Anti-MUC1 Single Domain Antibody (aMUC1) ELISA Camel VHH
HPAB-0736-YJ-VHH Camelid Anti-MUC1 Recombinant Single Domain Antibody (ER46) ELISA Camelid VHH
HPAB-0737-YJ-VHH Camelid Anti-MUC1 Recombinant Single Domain Antibody (AR-32) ELISA Camelid VHH

Humanized Antibody

CAT Product Name Application Type
TAB-173 Anti-Human MUC1 Recombinant Antibody (Cantuzumab Ravtansine) IF, IP, Neut, FuncS, ELISA, FC, ICC IgG1 - kappa
TAB-037-F(E) Anti-Human MUC1 Recombinant Antibody Fab Fragment (Clivatuzumab Tetraxetan) Neut, ELISA, IF, IP, FuncS, FC, IHC Fab - G1 - kappa
TAB-H77 Human Anti-MUC1 Recombinant Antibody (TAB-H77) FuncS, Inhib IgG1, κ
TAB-413MZ Human Anti-MUC1 Recombinant Antibody (TAB-413MZ) ELISA Humanized IgG
TAB-425MZ Anti-Human MUC1 Recombinant Antibody (huDMB5F3) ELISA, FC, FuncS, ICC Humanized antibody

Mouse Antibody

CAT Product Name Application Type
TAB-H56 Anti-Human MUC1 Recombinant Antibody (Pemtumomab) WB, FuncS, IF, Neut, ELISA, FC, IP IgG
TAB-0388CL Mouse Anti-Human MUC1 Recombinant Antibody WB, IHC
TAB-0388CL-S(P) Mouse Anti-Human MUC1 Recombinant Antibody scFv Fragment WB, IHC
TAB-0388CL-F(E) Mouse Anti-Human MUC1 Recombinant Antibody Fab Fragment WB, IHC
PABX-183-S (P) Recombinant Mouse Anti-MUC1 Antibody scFv Fragment (CTM01) Neut, FuncS scFv

Immunotoxin

CAT Product Name Application Type
AGTO-L036E anti-MUC1 immunotoxin C242 (Fab)-PE Cytotoxicity assay, Functional assay
AGTO-L064E anti-MUC1 immunotoxin H23 (scFv)-PE Cytotoxicity assay, Functional assay

Fab Fragment Antibody

CAT Product Name Application Type
PFBL-656 Mouse Anti-MUC1 Recombinant Antibody; Fab Fragment WB, IF, FuncS Mouse Fab
FAMAB-0225-YC-F(E) Mouse Anti-MUC1 Recombinant Antibody (clone MUSE11); Fab Fragment IHC Mouse Fab
HPAB-0670-CN-F(E) Human Anti-MUC1 Recombinant Antibody; Fab Fragment (HPAB-0670-CN-F(E)) FC Human Fab
HPAB-0272CQ-F(E) Human Anti-MUC1 Recombinant Antibody; Fab Fragment (HPAB-0272CQ-F(E)) ELISA, FC, FuncS Human Fab
HPAB-J0212-YC-F(E) Mouse Anti-MUC1 Recombinant Antibody (clone BW835); Fab Fragment ELISA, IHC Mouse Fab

Chimeric Antibody

CAT Product Name Application Type
TAB-412MZ Human Anti-MUC1 Recombinant Antibody (TAB-412MZ) ELISA Chimeric (mouse/human) IgG
TAB-412MZ-S(P) Mouse Anti-MUC1 Recombinant Antibody; scFv Fragment (TAB-412MZ-S(P)) ELISA Mouse scFv
TAB-412MZ-F(E) Human Anti-MUC1 Recombinant Antibody; Fab Fragment (TAB-412MZ-F(E)) ELISA Chimeric (mouse/human) Fab

Human Antibody

CAT Product Name Application Type
TAB-431MZ-S(P) Anti-Human MUC1 Recombinant Antibody scFv Fragment (PH1) ELISA, WB, FC, IHC Human antibody
TAB-432MZ-S(P) Human Anti-MUC1 Recombinant Antibody; scFv Fragment (TAB-432MZ-S(P)) ELISA, FC Human scFv
TAB-433MZ-S(P) Human Anti-MUC1 Recombinant Antibody; scFv Fragment (TAB-433MZ-S(P)) ELISA, FC Human scFv
TAB-434MZ-S(P) Human Anti-MUC1 Recombinant Antibody; scFv Fragment (TAB-434MZ-S(P)) ELISA, FC Human scFv
PABX-143 Recombinant Human Anti-MUC1 Antibody (CTM01) WB, ELISA, FuncS IgG

Fab Glycosylation

CAT Product Name Application Type
Gly-012LC Recombinant Anti-Human MUC1 Antibody (Fab glycosylation/Sialylated) ELISA, FC, IHC Humanized antibody
Gly-120LC Recombinant Anti-Human MUC1 Antibody (Fab glycosylation) ELISA Mouse antibody

Sialylated IgG Glycan

CAT Product Name Application Type
Gly-012LC-1 Recombinant Anti-Human MUC1 Antibody (Fab glycosylation/Sialylated) ELISA, FC, IHC Humanized antibody

Fc Glycosylation

CAT Product Name Application Type
Gly-109LC Recombinant Anti-Human MUC1 Antibody (Fc glycosylation) ELISA Human antibody

Deglycosylated Antibody (Non-glycosylated IgGs)

CAT Product Name Application Type
Gly-121LC Recombinant Anti-Human MUC1 Antibody (Non-glycosylated) ELISA Mouse antibody
Gly-122LC Recombinant Anti-Human MUC1 Antibody (Non-glycosylated) ELISA Mouse antibody
Gly-123LC Recombinant Anti-Human MUC1 Antibody (Non-glycosylated) ELISA Mouse antibody
Gly-124LC Recombinant Anti-Human MUC1 Antibody (Non-glycosylated) ELISA Mouse antibody

Chicken IgY Antibody

CAT Product Name Application Type
BRD-0379MZ Chicken Anti-MUC1 Polyclonal IgY IHC, WB Chicken antibody

MHC Tetramer for Cancer

CAT Product Name Application Type
MHC-LC054 PE-A*02:01/Human MUC1 (LLLTVLTVV) MHC Tetramer FCM
MHC-LC055 APC-A*02:01/Human MUC1 (LLLTVLTVV) MHC Tetramer FCM
MHC-LC056 BV421-A*02:01/Human MUC1 (LLLTVLTVV) MHC Tetramer FCM
MHC-LC096 PE-A*02:01/Human MUC1 (LLLLTVLTV) MHC Tetramer FCM
MHC-LC097 APC-A*02:01/Human MUC1 (LLLLTVLTV) MHC Tetramer FCM

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-2320 Hi-Affi™ Recombinant Rabbit Anti-MUC1 Monoclonal Antibody (DS2320AB) IHC-P, IHC-Fr IgG

Epitope-Specific Antibody

CAT Product Name Application Type
EPAF-0838LC Recombinant Mouse Anti-Human MUC1 Antibody (SM3) ELISA IgG1
EPAF-0581CQ Recombinant Mouse Anti-Human MUC1 Antibody (B27.29) Neut, FC IgG1
EPAF-0583CQ Recombinant Mouse Anti-Human MUC1 Antibody (BC4E549) Neut, FC IgG1
EPAF-0584CQ Recombinant Mouse Anti-Human MUC1 Antibody (DF3) Neut, FC IgG1

Recombinant Antibody

CAT Product Name Application Type
MOB-124CQ Mouse Anti-Human MUC1 Antibody IHC, IF Mouse IgG1, κ
FAMAB-0225YC Mouse Anti-MUC1 Recombinant Antibody (clone MUSE11) IHC Mouse IgG1
HPAB-0872LY Mouse Anti-MUC1 Recombinant Antibody (HPAB-0872LY) ELISA, WB, FC Mouse IgG1
HPAB-0873LY Human Anti-MUC1 Recombinant Antibody (HPAB-0873LY) ELISA, WB, FC Humanized IgG1
HPAB-0874LY Mouse Anti-MUC1 Recombinant Antibody (HPAB-0874LY) ELISA, WB, FC Mouse IgG1

scFv Fragment Antibody

CAT Product Name Application Type
PSBC-399 Mouse Anti-MUC1 Recombinant Antibody (clone AR20.5); scFv Fragment ELISA, FC, FuncS Mouse scFv
PSBC-400 Mouse Anti-MUC1 Recombinant Antibody (clone SM3); scFv Fragment FC, IHC-Fr, IF, ELISA, IHC-P Mouse scFv
HPAB-J0212-YC-S(P) Mouse Anti-MUC1 Recombinant Antibody (clone BW835); scFv Fragment ELISA, IHC Mouse scFv
HPAB-1165WJ-S(P) Mouse Anti-MUC1 Recombinant Antibody (clone B9); scFv Fragment ELISA, ICC Mouse scFv
FAMAB-0211JF-S(P) Human Anti-MUC1 Recombinant Antibody (clone G8); scFv Fragment ELISA, FuncS Human scFv

ADCC Enhanced Antibody

CAT Product Name Application Type
AFC-TAB-H65 Afuco™ Anti-MUC1 ADCC Recombinant Antibody (Sontuzumab), ADCC Enhanced ELISA, FC, IP, FuncS, IF ADCC enhanced antibody
AFC-TAB-026ML Afuco™ Anti-MUC1 ADCC Recombinant Antibody (Gatipotuzumab), ADCC Enhanced ELISA, IHC, FC, IP, IF, FuncS ADCC enhanced antibody
AFC-TAB-166 Afuco™ Anti-MUC1 ADCC Recombinant Antibody (Cantuzumab), ADCC Enhanced IP, IF, FuncS, FC, Neut, ELISA ADCC enhanced antibody
AFC-TAB-H77 Afuco™ Human Anti-MUC1 Recombinant Antibody, ADCC Enhanced (AFC-TAB-H77) ELISA, FC, IP, FuncS, IF IgG1, κ

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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