Human Anti-PRNP Recombinant Antibody (clone D18) (CAT#: FAMAB-0294-CN)
This is a monoclonal antibody which is specific to a normal cellular protein (PrP). The mAb D18 can be used for applications such as: WB, IF, IHC.
Specific Inquiry
IF
Figure 1 Antibodies recognizing the C-terminal domain of PrPC induce dendritic degeneration in hippocampal neurons.
Top, representative images showing dendrite morphology of cultured hippocampal neurons from Tga20 mice (which over-express WT PrPC), WT mice, or Prnp−/− mice after treatment for 48 hr with D18 (16.7 nM). The cells were stained with an antibody to MAP2 to visualize dendrites. Boxed areas are enlarged below each image. Scale bar = 10 µm. Bottom, quantitation of dendritic degeneration, expressed as the length of beaded dendrite segments as a percentage of total dendrite length, from 10 images in three independent cultures for each experimental condition. Data represent mean ± S.E.M. **p<0.01; ***p<0.005.
Wu, B., McDonald, A. J., Markham, K., Rich, C. B., McHugh, K. P., Tatzelt, J., ... & Harris, D. A. (2017). The N-terminus of the prion protein is a toxic effector regulated by the C-terminus. Elife, 6, e23473.
Specifications
- Host Species
- Human
- Derivation
- Phage display library
- Type
- Human IgG
- Specificity
- Human PRNP
- Species Reactivity
- Human
- Clone
- D18
- Applications
- WB, IF, IHC
- Related Disease
- Alzheimer's or Parkinson's disease
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- This antibody has been reported for use in Western Blot, Immunofluorescence and Immunohistochemistry.
Target
- Alternative Names
- CJD; GSS; PrP; ASCR; KURU; PRIP; PrPc; CD230; AltPrP; p27-30; PrP27-30; PrP33-35C
- Gene ID
- 5621
- UniProt ID
- P04156
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "Clone D18"
See other products for "PRNP"
Select a product category from the dropdown menu below to view related products.
Please select product type
Intrabody Products
IgG Antibody Products
Single Domain Antibody Products
Fab Antibody Products
Human Antibody Products
IgM Antibody Products
Mouse Antibody Products
Chicken IgY Antibody Products
Rabbit Monoclonal Antibody Products
Epitope-Specific Antibody Products
ScFv Antibody Products
ScFv-Fc Chimera Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| IAB-B034(A) | Recombinant Anti-human PRNP Intrabody [(D-Arg)9] | IF, FC, WB, FuncS | scFv-(D-Arg)9 |
| IAB-B034(G) | Recombinant Anti-human PRNP Intrabody [+36 GFP] | WB, CO-IP, FuncS | scFv-(+36GFP) |
| IAB-B034(T) | Recombinant Anti-human PRNP Intrabody [Tat] | IF, ELISA, FuncS | scFv-Tat |
Customer Reviews and Q&As
There are currently no Customer reviews or questions for FAMAB-0294-CN. Click the button above to contact us or submit your feedback about this product.
Popular products with customers
Application: WB, ELISA, IP, FC, FuncS, Neut, IF
Application: WB, ELISA, FC, IP, FuncS, IF, Neut
Application: ELISA, FC, IP, FuncS, IF, Neut, ICC
Application: IP, IF, FuncS, FC, Neut, ELISA, ICC
Application: IP, IF, FuncS, FC, Neut, ELISA, IHC
Application: Neut, ELISA, IF, IP, FuncS, FC, WB
Application: FuncS, IF, Neut, ELISA, FC, IP, WB
Application: FuncS, IF, Neut, ELISA, FC, IP, ICC
Application: WB, IHC, FC, Cyt, ELISA
Application: FuncS, Inhib, IP, ELISA
Application: FC, FRET, Internalization
Application: ELISA, IHC, FC, IP, IF, FuncS
For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
