ERBB2
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- Derivation: Humanized (from mouse)
- Species Reactivity: Human
- Type: IgG1 - kappa
- Application: FC, IP, ELISA, Neut, FuncS, IF, IHC
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- Derivation: Chimeric (Human/Mouse)
- Species Reactivity: Human
- Type: IgG1 - kappa
- Application: IF, IP, Neut, FuncS, ELISA, FC, WB
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- Derivation: Humanized (from mouse)
- Species Reactivity: Human
- Type: IgG1 - kappa
- Application: FuncS, IF, Neut, ELISA, FC, IP, WB
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- Derivation: Phage display library
- Species Reactivity: Human
- Type: Humanized scFv
- Application: WB
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- Anti-Human HER2/neu Recombinant Antibody scFv Fragment (h1E11) (TAB-039CT-S(P))
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- Derivation: Mouse 1E11
- Species Reactivity: Human
- Type: Humanized antibody
- Application: WB
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- Human Anti-ERBB2 Recombinant Antibody; Fab Fragment (TAB-033CT-F(E)) (TAB-033CT-F(E))
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized Fab
- Application: ELISA, WB
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- Human Anti-ERBB2 Recombinant Antibody (TAB-0191CL) (TAB-0191CL)
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- Species Reactivity: Human
- Type: Human IgG
- Application: ELISA, Cyt, Internalization
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- Human Anti-ERBB2 Recombinant Antibody (TAB-0192CL) (TAB-0192CL)
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- Species Reactivity: Human
- Type: Human IgG
- Application: ELISA, ADCC, Cyt, Internalization
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- Human Anti-ERBB2 Recombinant Antibody (TAB-0193CL) (TAB-0193CL)
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- Species Reactivity: Human
- Type: Human IgG
- Application: ELISA, ADCC, Cyt, Internalization
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- Human Anti-ERBB2 Recombinant Antibody (TAB-0194CL) (TAB-0194CL)
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- Species Reactivity: Human
- Type: Human IgG
- Application: ELISA, ADCC, Cyt, Internalization
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- Human Anti-ERBB2 Recombinant Antibody; Fab Fragment (TAB-0191CL-F(E)) (TAB-0191CL-F(E))
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- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA, Cyt, Internalization
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- Human Anti-ERBB2 Recombinant Antibody; Fab Fragment (TAB-0192CL-F(E)) (TAB-0192CL-F(E))
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- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA, Cyt, Internalization
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- Human Anti-ERBB2 Recombinant Antibody; scFv Fragment (TAB-0191CL-S(P)) (TAB-0191CL-S(P))
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- Species Reactivity: Human
- Type: Human scFv
- Application: ELISA, Cyt, Internalization
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- Derivation: Humanized (from mouse)
- Species Reactivity: Human
- Type: IgG1 - kappa
- Application: ELISA, IP, FC, FuncS, Neut, IF, ICC
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- Recombinant Human Anti-HER2 Antibody (Gr3) (PABX-081)
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- Derivation: Human
- Species Reactivity: Human
- Type: IgG
- Application: WB, ELISA, FuncS
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- Recombinant Human Anti-HER2 Antibody (Gr6) (PABX-082)
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- Derivation: Human
- Species Reactivity: Human
- Type: IgG
- Application: WB, ELISA, FuncS
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- Recombinant Human Anti-HER2 Antibody scFv Fragment (Gr3) (PABX-081-S (P))
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- Derivation: Human
- Species Reactivity: Human
- Type: scFv
- Application: WB, ELISA, FuncS
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- Human Anti-ERBB2 Recombinant Antibody; scFv Fragment (TAB-0192CL-S(P)) (TAB-0192CL-S(P))
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- Species Reactivity: Human
- Type: Human scFv
- Application: ELISA, Cyt, Internalization
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- Human Anti-ERBB2 Recombinant Antibody; scFv Fragment (TAB-0193CL-S(P)) (TAB-0193CL-S(P))
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- Species Reactivity: Human
- Type: Human scFv
- Application: ELISA, Cyt, Internalization
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- Human Anti-ERBB2 Recombinant Antibody; scFv Fragment (TAB-0194CL-S(P)) (TAB-0194CL-S(P))
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- Species Reactivity: Human
- Type: Human scFv
- Application: ELISA, Cyt, Internalization
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- Human Anti-ERBB2 Recombinant Antibody; Fab Fragment (TAB-0193CL-F(E)) (TAB-0193CL-F(E))
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- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA, Cyt, Internalization
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- Derivation: Phage display library
- Species Reactivity: Human
- Type: Humanized IgG1
- Application: FuncS, FC
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- Anti-Human HER2/neu Recombinant Antibody (h1E11) (TAB-039CT)
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- Derivation: Mouse 1E11
- Species Reactivity: Human
- Type: Humanized antibody
- Application: WB
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- Anti-Human HER2/neu Recombinant Antibody (C6.5) (TAB-040CT)
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- Derivation: Phage display library
- Species Reactivity: Human
- Type: Human antibody
- Application: ELISA, WB
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- Anti-Human HER2/neu Recombinant Antibody (CRX01) (TAB-042CT)
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- Species Reactivity: Human
- Type: Human antibody
- Application: WB
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- Anti-Human HER2/neu Recombinant Antibody scFv Fragment (C6.5) (TAB-040CT-S(P))
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- Derivation: Phage display library
- Species Reactivity: Human
- Type: Human antibody
- Application: FC, IP, Block
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- Anti-Human HER2/neu Recombinant Antibody scFv Fragment (CRX01) (TAB-042CT-S(P))
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- Species Reactivity: Human
- Type: Human antibody
- Application: WB
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- Derivation: Phage display library
- Species Reactivity: Human
- Type: Human antibody
- Application: WB, FC, IF, Funcs
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- Anti-Human HER2/neu Recombinant Antibody scFv Fragment (Erbicin) (TAB-045CT-S(P))
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- Derivation: Phage display library
- Species Reactivity: Human
- Type: Human antibody
- Application: ELISA, Inhibition
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- Anti-Human HER2/neu Recombinant Antibody scFv Fragment (ChA21) (TAB-049CT-S(P))
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- Species Reactivity: Human
- Type: Chimeric antibody (mouse/human)
- Application: WB
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- Anti-Human HER2/neu Recombinant Antibody scFv Fragment (HuA21) (TAB-050CT-S(P))
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- Species Reactivity: Human
- Type: Humanized antibody
- Application: ELISA, WB
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- Humanized Anti-Human HER2/neu Recombinant Antibody scFv Fragment (TAB-054CT-S(P))
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- Species Reactivity: Human
- Type: Humanized antibody
- Application: ELISA, Inhibition, FC
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- Anti-Human HER2/neu Recombinant Antibody scFv Fragment (TAB-055CT-S(P))
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- Derivation: Phage display library
- Species Reactivity: Human
- Type: Human antibody
- Application: WB
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- Recombinant Human Anti-HER2 Antibody Fab Fragment (Gr3 ) (PABX-081-F (E))
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- Derivation: Human
- Species Reactivity: Human
- Type: Fab
- Application: WB, ELISA, FuncS
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- Recombinant Human Anti-HER2 Antibody Fab Fragment (Gr6) (PABX-082-F (E))
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- Derivation: Human
- Species Reactivity: Human
- Type: Fab
- Application: WB, ELISA, FuncS
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- Derivation: Phage display library
- Species Reactivity: Human
- Type: Human antibody
- Application: FC, Inhib, IF, Cyt, WB, Apop
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- Derivation: Phage display library
- Species Reactivity: Human
- Type: Human antibody
- Application: ELISA, Inhibition
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- Anti-Human HER2/neu Recombinant Antibody (ChA21) (TAB-049CT)
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- Species Reactivity: Human
- Type: Chimeric antibody (mouse/human)
- Application: IHC, Inhib, WB, Activ, FC
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- Anti-Human HER2/neu Recombinant Antibody (HuA21) (TAB-050CT)
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- Species Reactivity: Human
- Type: Humanized antibody
- Application: Inhib, Cty, IHC, WB, IF, FC, ELISA
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- Anti-Human HER2/neu Recombinant Antibody (TAB-055CT)
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- Derivation: Phage display library
- Species Reactivity: Human
- Type: Human antibody
- Application: WB
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- Human Anti-ERBB2 Recombinant Antibody; Fab Fragment (TAB-038CT-F(E)) (TAB-038CT-F(E))
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- Derivation: Phage display library
- Species Reactivity: Human
- Type: Humanized Fab
- Application: WB
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- Anti-Human HER2/neu Recombinant Antibody Fab Fragment (h1E11) (TAB-039CT-F(E))
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- Derivation: Mouse 1E11
- Species Reactivity: Human
- Type: Humanized antibody
- Application: WB
Compare
- Anti-Human HER2/neu Recombinant Antibody Fab Fragment (C6.5) (TAB-040CT-F(E))
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- Derivation: Phage display library
- Species Reactivity: Human
- Type: Human antibody
- Application: ELISA, WB
Compare
- Human Anti-ERBB2 Recombinant Antibody; Fab Fragment (TAB-041CT-F(E)) (TAB-041CT-F(E))
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- Species Reactivity: Human
- Type: Humanized Fab
- Application: ELISA, WB
Compare
- Anti-Human HER2/neu Recombinant Antibody Fab Fragment (CRX01) (TAB-042CT-F(E))
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- Species Reactivity: Human
- Type: Human antibody
- Application: WB
Compare
- Human Anti-ERBB2 Recombinant Antibody; Fab Fragment (TAB-043CT-F(E)) (TAB-043CT-F(E))
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- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA, Inhibion
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- Derivation: Phage display library
- Species Reactivity: Human
- Type: Human antibody
- Application: WB
Compare
- Anti-Human HER2/neu Recombinant Antibody Fab Fragment (Erbicin) (TAB-045CT-F(E))
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- Derivation: Phage display library
- Species Reactivity: Human
- Type: Human antibody
- Application: ELISA, Inhibition
Compare
- Human Anti-ERBB2 Recombinant Antibody; Fab Fragment (TAB-048CT-F(E)) (TAB-048CT-F(E))
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- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA, WB
Compare
- Anti-Human HER2/neu Recombinant Antibody Fab Fragment (ChA21) (TAB-049CT-F(E))
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- Species Reactivity: Human
- Type: Chimeric antibody (mouse/human)
- Application: WB
Compare
- Anti-Human HER2/neu Recombinant Antibody Fab Fragment (HuA21) (TAB-050CT-F(E))
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- Species Reactivity: Human
- Type: Humanized antibody
- Application: ELISA, WB
Compare
- Human Anti-ERBB2 Recombinant Antibody; Fab Fragment (TAB-053CT-F(E)) (TAB-053CT-F(E))
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- Species Reactivity: Human
- Type: Humanized Fab
- Application: ELISA, Inhib, FC
Compare
- Humanized Anti-Human HER2/neu Recombinant Antibody Fab Fragment (TAB-054CT-F(E))
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- Species Reactivity: Human
- Type: Humanized antibody
- Application: ELISA, Inhibition, FC
Compare
- Anti-Human HER2/neu Recombinant Antibody Fab Fragment (TAB-055CT-F(E))
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- Derivation: Phage display library
- Species Reactivity: Human
- Type: Human antibody
- Application: WB
Compare
- Human Anti-ERBB2 Recombinant Antibody; Fab Fragment (TAB-056CT-F(E)) (TAB-056CT-F(E))
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- Species Reactivity: Human
- Type: Human Fab
- Application: WB
Compare
- Human Anti-ERBB2 Recombinant Antibody; Fab Fragment (TAB-0194CL-F(E)) (TAB-0194CL-F(E))
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- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA, Cyt, Internalization
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- Derivation: Humanized
- Species Reactivity: Human
- Type: IgG1, κ
- Application: ELISA, IHC, FC, IP, IF, FuncS
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- Derivation: Phage display library
- Species Reactivity: Human
- Type: Single domain antibody
- Application: ELISA, Inhibition, FC
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- Derivation: Phage display library
- Species Reactivity: Human
- Type: Single domain antibody
- Application: WB
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- Anti-Human HER2/neu Recombinant Antibody Fab Fragment (7C2) (TAB-037CT-F(E))
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- Derivation: Hybridoma cell line
- Species Reactivity: Human
- Application: ELISA, WB
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- Mouse Anti-ERBB2 Recombinant Antibody; Fab Fragment (TAB-270CQ-F(E)) (TAB-270CQ-F(E))
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- Species Reactivity: Human
- Type: Mouse Fab
- Application: WB, Inhib
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- Recombinant llama Anti-ERBB2 Antibody (HPAB-0203-FY)
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- Species Reactivity: Human
- Type: llama VHH
- Application: IF
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- Recombinant llama Anti-ERBB2 Antibody (HPAB-0201-FY) (HPAB-0201-FY)
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- Species Reactivity: Human
- Type: llama VHH
- Application: E
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- Recombinant llama Anti-ERBB2 Antibody (HPAB-0202-FY) (HPAB-0202-FY)
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- Species Reactivity: Human
- Type: llama VHH
- Application: E
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- Anti-Human HER2/neu Recombinant Antibody (6B2) (TAB-036CT)
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- Derivation: Hybridoma cell line
- Species Reactivity: Human
- Application: ELISA, WB
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- Anti-Human HER2/neu Recombinant Antibody (7C2) (TAB-037CT)
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- Derivation: Hybridoma cell line
- Species Reactivity: Human
- Application: ELISA, WB
Compare
- Recombinant Human Anti-HER2 Antibody scFv Fragment (Gr6) (PABX-082-S (P))
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- Derivation: Human
- Species Reactivity: Human
- Type: scFv
- Application: WB, ELISA, FuncS
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- Recombinant Camelid Anti-ERBB2 Single Domain Antibody (HPAB-1026WJ)
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- Species Reactivity: Human
- Type: Camelid VHH
- Application: ELISA
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- Camelid Anti-ERBB2 Recombinant Single Domain Antibody (HPAB-0725-YJ-VHH) (HPAB-0725-YJ-VHH)
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- Derivation: Phage display library
- Species Reactivity: Human
- Type: Camelid VHH
- Application: ELISA
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- Anti-Human HER2/neu Recombinant Antibody scFv Fragment (6B2) (TAB-036CT-S(P))
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- Derivation: Hybridoma cell line
- Species Reactivity: Human
- Application: ELISA, WB
Compare
- Anti-Human HER2/neu Recombinant Antibody scFv Fragment (7C2) (TAB-037CT-S(P))
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- Derivation: Hybridoma cell line
- Species Reactivity: Human
- Application: ELISA, WB
Compare
- Anti-Human HER2/neu Recombinant Antibody Fab Fragment (6B2) (TAB-036CT-F(E))
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- Derivation: Hybridoma cell line
- Species Reactivity: Human
- Application: ELISA, WB
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- Derivation: Phage display library
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: IHC-P, IHC-Fr
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- Chicken Anti-ERBB2 Polyclonal IgY (BRD-0195MZ)
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- Species Reactivity: Human, Mouse, Rat
- Type: Chicken antibody
- Application: WB
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More Infomation
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For Research Use Only. Not For Clinical Use.
Background
A receptor tyrosine kinase involved in cell growth and differentiation. Overexpression is a significant driver in several cancers, particularly breast and gastric cancer.
Protein class
Cancer-related genes, CD markers, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins
Predicted location
Intracellular, Membrane (different isoforms)
Single cell type specificity
Cell type enhanced (Collecting duct cells, Proximal enterocytes, Distal enterocytes)
Immune cell specificity
Immune cell enhanced (gdT-cell)
Cell line specificity
Group enriched (OE19, SK-BR-3)
Interaction
Homodimer (PubMed:21454582). Heterodimer with EGFR, ERBB3 and ERBB4 (PubMed:10358079, PubMed:15093539, PubMed:21190959, PubMed:16978839). Part of a complex with EGFR and either PIK3C2A or PIK3C2B. May interact with PIK3C2B when phosphorylated on Tyr-1196 (PubMed:10805725). Interacts with PLXNB1 (PubMed:15210733). Interacts (when phosphorylated on Tyr-1248) with MEMO1 (PubMed:15156151). Interacts with MUC1; the interaction is enhanced by heregulin (HRG) (PubMed:12939402). Interacts (when phosphorylated on Tyr-1139) with GRB7 (via SH2 domain) (PubMed:12975581). Interacts (when phosphorylated on Tyr-1248) with ERBIN (PubMed:12444095). Interacts with KPNB1, RANBP2, EEA1, CRM1 and CLTC (PubMed:16314522). Interacts with PTK6 (PubMed:18719096). Interacts with RPA194 and ACTB (PubMed:21555369). Interacts with PRKCABP, SRC and MYOC (By similarity). Interacts (preferentially with the tyrosine phosphorylated form) with CPNE3; this interaction occurs at the cell membrane and is increased in a growth factor heregulin-dependent manner (PubMed:20010870). Interacts with HSP90AA1 and HSP90AB1 in an ATP-dependent manner; the interaction suppresses ERBB2 kinase activity (PubMed:26517842). Interacts with SORL1; this interaction regulates ERBB2 subcellular distribution by promoting its recycling after internalization from endosomes back to the plasma membrane, hence stimulates ERBB2-mediated signaling (PubMed:31138794).
Molecular function
Activator, Kinase, Receptor, Transferase, Tyrosine-protein kinase
More Types Infomation
Related Diseases
Bladder Cancer
Non-small Cell Lung Cancer
Related Signaling Pathways
ErbB Signaling Pathway