Anti-Human ERBB2 Recombinant Antibody (TAB-053) (CAT#: TAB-053)
Recombinant monoclonal antibody to ERBB2. It is a monoclonal antibody. The first of its class in a line of agents called "HER dimerization inhibitors". By binding to HER2, it inhibits the dimerization of HER2 with other HER receptors, which is hypothesized to result in slowed tumor growth.
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SPR
Figure 1 Anti-Human ERBB2 Recombinant Antibody (TAB-053) in SPR
SPR assays of TAB-053.
The affinity of Anti-Human ERBB2 Antibody (TAB-053) was determined by SPR.
Captured TAB-053 on CM5 Chip via Anti-Human IgG (Fc) can bind Human ERBB2 protein with an affinity constant of 1.88 nM as determined in a SPR assay (Biacore 8K).
ELISA
Figure 2 Anti-ErbB2 Antibody (TAB-053) in ELISA
ELISA analysis of TAB-053 was performed by coating with human ErbB2 protein.
DB
Figure 3 Anti-ErbB2 Antibody (TAB-053) in Dot Blot
Dot Blot analysis of TAB-053 was performed by coating with human ErbB2 protein.
Specifications
- Immunogen
- The details of the immunogen for this antibody are not available.
- Host Species
- Mouse
- Derivation
- Humanized (from mouse)
- Type
- IgG1 - kappa
- Specificity
- Tested positive against native human antigen.
- Species Reactivity
- Human
- Applications
- FuncS, IF, Neut, ELISA, FC, IP, WB
- Related Disease
- Prostate cancers
Product Property
- Purity
- >95.0% as determined by Analysis by RP-HPLC & analysis by SDS-PAGE.
- Storage
- Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- The ERBB2 antibody has been reported in applications of WB, Internalization, IF, Inhib.
Inhibition: In short-term experiments, trastuzumab (10 ng/μl), pertuzumab (10 ng/μl) and erlotinib (1 μM) were added to cells in starvation medium either alone or in combinations 1 h prior to growth-factor stimulation.
Target
- Alternative Names
- Pertuzumab;pertuzumab, Omnitarg;380610-27-5;rhuMAb 2C4;RG1273;pertuzumab;2C4;pertuzumab;Omnitarg;ERBB2;v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian);NGL, v erb b2 avian erythroblastic leukemia viral
- Gene ID
- 2064
- UniProt ID
- P04626
Related Resources
Bladder Cancer
Non-small Cell Lung Cancer
ErbB Signaling Pathway
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
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Extracellular Vesicle (EV) Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| IAB-B008(A) | Recombinant Anti-human ERBB2 Intrabody [(D-Arg)9] | IF, FC, FuncS | scFv-(D-Arg)9 |
| IAB-B008(G) | Recombinant Anti-human ERBB2 Intrabody [+36 GFP] | WB, ICC, FuncS | scFv-(+36GFP) |
| IAB-B008(T) | Recombinant Anti-human ERBB2 Intrabody [Tat] | ICC, Neut, FuncS | scFv-Tat |
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Cite This Product
To accurately reference this product in your publication, please use the following citation information:
(Creative Biolabs Cat# TAB-053, RRID: AB_3111779)
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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