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Anti-ERBB2 Recombinant Antibody (Margetuximab)

Anti-ERBB2 Recombinant Antibody (Margetuximab) (CAT#: TAB-761)

Recombinant chimeric (mouse/human) antibody expressed in CHO binding to human ERBB2. Margetuximab is a monoclonal antibody designed for the treatment of cancer.

Tested Data
Gene Expression
Datasheet
MSDS
COA

SPR

Figure 1 Anti-ERBB2 Recombinant Antibody (Margetuximab) (TAB-761) in SPR

Figure 1 Anti-ERBB2 Recombinant Antibody (Margetuximab) (TAB-761) in SPR

SPR assays of TAB-761.
The affinity of Anti-ERBB2 Therapeutic Antibody (Margetuximab) (TAB-761) was determined by SPR.
Captured TAB-761 on CM5 Chip via Anti-Human IgG (Fc) can bind Human ERBB2 protein with an affinity constant of 1.21 nM as determined in a SPR assay (Biacore 8K).

Subcellular Location

Figure 1 IF staining of human cell line U-251 MG
(Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/1060/169_D12_1_selected.jpg

Figure 2 IF staining of human cell line A-431
(Immunofluorescent staining of human cell line A-431 shows localization to plasma membrane.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/1338/if_selected.jpg

Normal Tissue

Figure 3 High expression in esophagus

* Image credit: Human Protein Atlas v21.proteinatlas.org/images/1383/4682_B_5_1_val_selected.jpg

Figure 4 IHC staining of human rectum
(Immunohistochemical staining of human rectum shows weak cytoplasmic positivity in glandular cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/43/ihc_selected.jpg

Figure 5 IHC staining of human urinary bladder
(Immunohistochemical staining of human urinary bladder shows moderate cytoplasmic and membranous positivity in urothelial cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/20416/ihc_selected.jpg

Figure 6 Kidney
(Collecting ducts Staining: Low Intensity: Moderate Quantity: <25% Distal tubules Staining: Low Intensity: Moderate Quantity: <25%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/43/1054_A_7_5.jpg

Figure 7 Breast
(Glandular cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Myoepithelial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/20416/45831_B_3_4.jpg

RNA Expression

Figure 8 RNA cell line category: Group enriched (OE19, SK-BR-3)
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000141736-ERBB2

Datasheet

MSDS

Certificate of Analysis Lookup
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number

Specifications

Immunogen
The details of the immunogen for this antibody are not available.

Host Species
Mouse

Derivation
Chimeric (Human/Mouse)

Type
IgG1 - kappa

Species Reactivity
Human

Applications
Suitable for use in FuncS, IF, Neut, ELISA, FC, IP, ICC and most other immunological methods.

CAS
1350624-75-7

Generic Name
margetuximab

MW
145.9 kDa

Related Disease
Solid tumors

Product Property

Purity
>95%, by SDS-PAGE with silver staining, under reducing conditions.

Storage
Store at -20°C for long-term storage. Store at 2-8°C for up to one month. Avoid freeze/thaw cycles.

Target

Alternative Names
margetuximab;1350624-75-7;MGAH22;4D5;ERBB2;v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian);NGL, v erb b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived onco

Gene ID
2064

UniProt ID
P04626

Related Resources

Biosimilar Overview
Related Diseases
Related Signaling Pathways

Please refer to Margetuximab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Margetuximab.

Bladder Cancer

Non-small Cell Lung Cancer

ErbB Signaling Pathway

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "Margetuximab"

Afuco™ Anti-ERBB2 ADCC Recombinant Antibody (Margetuximab), ADCC Enhanced
This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant chimeric (mouse/human) antibody expressed in CHO binding to human ERBB2. Margetuximab is a monoclonal antibody designed for the treatment of cancer.

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CAT	Product Name	Application	Type
IAB-B008(A)	Recombinant Anti-human ERBB2 Intrabody [(D-Arg)₉]	IF, FC, FuncS	scFv-(D-Arg)₉
IAB-B008(G)	Recombinant Anti-human ERBB2 Intrabody [+36 GFP]	WB, ICC, FuncS	scFv-(+36GFP)
IAB-B008(T)	Recombinant Anti-human ERBB2 Intrabody [Tat]	ICC, Neut, FuncS	scFv-Tat

CAT	Product Name	Application	Type
TAB-005	Anti-Human ErbB2 Recombinant Antibody (Trastuzumab)	FC, IP, ELISA, Neut, FuncS, IF, IHC	IgG1 - kappa
TAB-033CT-S(P)	Human Anti-ERBB2 Recombinant Antibody; scFv Fragment (TAB-033CT-S(P))	ELISA, WB	Human scFv
TAB-038CT-S(P)	Human Anti-ERBB2 Recombinant Antibody; scFv Fragment (TAB-038CT-S(P))	WB	Humanized scFv
TAB-039CT-S(P)	Anti-Human HER2/neu Recombinant Antibody scFv Fragment (h1E11)	WB	Humanized antibody
TAB-041CT-S(P)	Human Anti-ERBB2 Recombinant Antibody; scFv Fragment (TAB-041CT-S(P))	ELISA, WB	Humanized scFv

CAT	Product Name	Application
AGTO-G022E	Anti-ERBB2 immunotoxin 4D5 (scFv)-PE	Cytotoxicity assay, Function study
AGTO-G022D	Anti-ERBB2 immunotoxin 4D5 (scFv)-DT	Cytotoxicity assay, Function study
AGTO-G022G	Anti-ERBB2 immunotoxin 4D5 (scFv)-Gel	Cytotoxicity assay, Function study
AGTO-G022R	Anti-ERBB2 immunotoxin 4D5 (scFv)-RTA	Cytotoxicity assay, Function study
AGTO-G022S	Anti-ERBB2 immunotoxin 4D5 (scFv)-Sap	Cytotoxicity assay, Function study

CAT	Product Name	Application	Type
PFBZ-041	Human Anti-ERBB2 Recombinant Antibody (clone bH1); Fab Fragment	WB, IF, FuncS	Human Fab
PSBC-157	Human Anti-ERBB2 Recombinant Antibody (clone F0178C1); scFv Fragment	Neut	Human scFv
PSBC-158	Human Anti-ERBB2 Recombinant Antibody (clone Pertuzumab, 2C4); scFv Fragment	IP, Neut	Human scFv
HPAB-0010-FY-F(E)	Human Anti-ERBB2 Recombinant Antibody; Fab Fragment (HPAB-0010-FY-F(E))	ELISA, FC	Human Fab
HPAB-0011-FY-F(E)	Mouse Anti-ERBB2 Recombinant Antibody; Fab Fragment (HPAB-0011-FY-F(E))	Inhib	Mouse Fab

CAT	Product Name	Application	Type
TAB-040CT	Anti-Human HER2/neu Recombinant Antibody (C6.5)	ELISA, WB	Human antibody
TAB-045CT-F(E)	Anti-Human HER2/neu Recombinant Antibody Fab Fragment (Erbicin)	ELISA, Inhibition	Human antibody
TAB-055CT-F(E)	Anti-Human HER2/neu Recombinant Antibody Fab Fragment	WB	Human antibody
TAB-056CT-F(E)	Human Anti-ERBB2 Recombinant Antibody; Fab Fragment (TAB-056CT-F(E))	WB	Human Fab
PABX-081-S (P)	Recombinant Human Anti-HER2 Antibody scFv Fragment (Gr3)	WB, ELISA, FuncS	scFv

CAT	Product Name	Application	Type
TAB-049CT	Anti-Human HER2/neu Recombinant Antibody (ChA21)	IHC, Inhib, WB, Activ, FC	Chimeric antibody (mouse/human)
TAB-049CT-S(P)	Anti-Human HER2/neu Recombinant Antibody scFv Fragment (ChA21)	WB	Chimeric antibody (mouse/human)
TAB-049CT-F(E)	Anti-Human HER2/neu Recombinant Antibody Fab Fragment (ChA21)	WB	Chimeric antibody (mouse/human)

CAT	Product Name	Application	Type
TAB-034CT-S(P)	Anti-Human HER2/neu Recombinant Antibody scFv Fragment (pertuzumab )	WB
TAB-036CT-S(P)	Anti-Human HER2/neu Recombinant Antibody scFv Fragment (6B2)	ELISA, WB
TAB-270CQ-S(P)	Mouse Anti-ERBB2 Recombinant Antibody; scFv Fragment (TAB-270CQ-S(P))	WB, Inhib	Mouse scFv
TAB-270CQ-F(E)	Mouse Anti-ERBB2 Recombinant Antibody; Fab Fragment (TAB-270CQ-F(E))	WB, Inhib	Mouse Fab
PABX-082-S (P)	Recombinant Human Anti-HER2 Antibody scFv Fragment (Gr6)	WB, ELISA, FuncS	scFv

CAT	Product Name	Application	Type
Gly-024LC	Recombinant Anti-Human ERBB2 Antibody (Fab glycosylation)	ELISA	Mouse antibody
Gly-039LC	Recombinant Anti-Human ERBB2 Antibody (Fab glycosylation)	ELISA	Human antibody

CAT	Product Name	Application	Type
Gly-145LC	Recombinant Anti-Human ERBB2 Antibody (Fc glycosylation)	ELISA	Human antibody
Gly-146LC	Recombinant Anti-Human ERBB2 Antibody (Fc glycosylation)	ELISA	Human antibody
Gly-147LC	Recombinant Anti-Human ERBB2 Antibody (Fc glycosylation)	ELISA	Human antibody
Gly-148LC	Recombinant Anti-Human ERBB2 Antibody (Fc glycosylation)	ELISA	Human antibody
Gly-149LC	Recombinant Anti-Human ERBB2 Antibody (Fc glycosylation)	ELISA	Human antibody

CAT	Product Name	Application	Type
Gly-177LC	Recombinant Anti-Human ERBB2 Antibody (Non-glycosylated)	ELISA	Humanized antibody

CAT	Product Name	Application	Type
BRD-0195MZ	Chicken Anti-ERBB2 Polyclonal IgY	WB	Chicken antibody
BRD-0695MZ	Chicken Anti-ERBB2 Polyclonal IgY	WB	Chicken antibody
BRD-0779MZ	Chicken Anti-ErbB2 Polyclonal IgY	ICC, IF, IHC, IP	Chicken antibody

CAT	Product Name	Application	Type
NEUT-737CQ	Mouse Anti-ERBB2 Recombinant Antibody (clone 7.16.4)	Block, IP, IF, FC	Mouse IgG2a

CAT	Product Name	Application	Type
MOR-1178	Hi-Affi™ Rabbit Anti-ERBB2 Recombinant Antibody (clone DS1178AB)	IHC-P, IHC-Fr	Rabbit IgG
MOR-4586	Hi-Affi™ Rabbit Anti-ERBB2 Recombinant Antibody (clone TH99DS)	WB	Rabbit IgG
MOR-4587	Hi-Affi™ Rabbit Anti-ERBB2 Recombinant Antibody (clone TH100DS)	WB	Rabbit IgG

CAT	Product Name	Application	Type
HPAB-0021-YC	Human Anti-ERBB2 Recombinant Antibody (HPAB-0021-YC)	ELISA, Neut, FC, FuncS	Human IgG
HPAB-0010-FY	Human Anti-ERBB2 Recombinant Antibody (HPAB-0010-FY)	ELISA, FC, ADCC	Human IgG1, κ
HPAB-0011-FY	Mouse Anti-ERBB2 Recombinant Antibody (HPAB-0011-FY)	Inhib, ADCC, FuncS	Mouse IgG1, κ
MRO-1926-CN	Rabbit Anti-ErbB2 Polyclonal Antibody (MRO-1926-CN)	WB, IF, IHC	Rabbit IgG
MRO-1927-CN	Rabbit Anti-ErbB2 Polyclonal Antibody (MRO-1927-CN)	WB, IF, IHC, FC	Rabbit IgG

CAT	Product Name	Application	Type
AFC-TAB-468CQ	Afuco™ Anti-ERBB2 ADCC Recombinant Antibody (Timigutuzumab), ADCC Enhanced	ELISA, IHC, FC, IP, IF, FuncS	ADCC enhanced antibody
AFC-TAB-053	Afuco™ Anti-ERBB2 ADCC Recombinant Antibody (Pertuzumab), ADCC Enhanced	FuncS, IF, Neut, ELISA, FC, IP	ADCC enhanced antibody
AFC-TAB-761	Afuco™ Anti-ERBB2 ADCC Recombinant Antibody (Margetuximab), ADCC Enhanced	IF, IP, Neut, FuncS, ELISA, FC	ADCC enhanced antibody
AFC-TAB-005	Afuco™ Anti-ERBB2 ADCC Recombinant Antibody (Trastuzumab), ADCC Enhanced	FC, IP, ELISA, Neut, FuncS, IF	ADCC enhanced antibody

CAT	Product Name	Application	Type
HPAB-1265WJ-S(P)	Human Anti-ERBB2 Recombinant Antibody; scFv Fragment (HPAB-1265WJ-S(P))	ELISA	Humanized scFv
HPAB-1333WJ-S(P)	Human Anti-ERBB2 Recombinant Antibody (clone 3.F2); scFv Fragment	ELISA, WB	Human scFv
HPAB-1334WJ-S(P)	Human Anti-ERBB2 Recombinant Antibody (clone 1.D2); scFv Fragment	ELISA, WB	Human scFv
HPAB-1335WJ-S(P)	Human Anti-ERBB2 Recombinant Antibody (clone 2.E8); scFv Fragment	ELISA, WB	Human scFv
HPAB-0679YY-S(P)	Human Anti-ERBB2 Recombinant Antibody (clone H2-18); scFv Fragment	ELISA	Human scFv

CAT	Product Name	Application
MHC-YF049	DRB1*01:01/Human HER2 (KVPIKWMALESILRRRF) MHC Monomer	MHC Multimer
MHC-YF475	A*02:01/Human HER2 (ILHDGAYSL) MHC Pentamer	FCM
MHC-YF476	A*02:01/Human HER2 (ALIHHNTHL) MHC Pentamer	FCM
MHC-YF477	A*02:01/Human HER-2/neu (LIAHNQVRQV) MHC Pentamer	FCM
MHC-YF478	A*02:01/Human HER-2/neu (KIFGSLAFL) MHC Pentamer	FCM

CAT	Product Name	Application	Type
VS-0424-XY91	AbPlus Anti-ERBB2 Magnetic Beads (3.F2)	IP, Protein Purification
VS-0724-YC1516	AbPlus Anti-Erbb2 Magnetic Beads (VS-0724-YC1516)	IP, Protein Purification

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(Creative Biolabs Cat# TAB-761, RRID: AB_3112005)

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