Anti-Human HER2/neu Recombinant Antibody (TAB-044CT)

Name: Anti-Human HER2/neu Recombinant Antibody (TAB-044CT)
SKU: TAB-044CT
Rating: 5 (1 reviews)

CAT#: TAB-044CT

Recombinant monoclonal antibody to HER2/neu. This antibody intended for the prophylaxis and treatment of ovarian carcinoma xenografts.

Gene Expression

Subcellular Location Figure 1 IF staining of human cell line U-251 MG

Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane.

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/1060/169_D12_1_selected.jpg

Subcellular Location Figure 2 IF staining of human cell line A-431

Immunofluorescent staining of human cell line A-431 shows localization to plasma membrane.

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/1338/if_selected.jpg

Normal Tissue Figure 3 High expression in esophagus

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/1383/4682_B_5_1_val_selected.jpg

Normal Tissue Figure 4 IHC staining of human rectum

Immunohistochemical staining of human rectum shows weak cytoplasmic positivity in glandular cells.

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/43/ihc_selected.jpg

Normal Tissue Figure 5 IHC staining of human urinary bladder

Immunohistochemical staining of human urinary bladder shows moderate cytoplasmic and membranous positivity in urothelial cells.

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/20416/ihc_selected.jpg

Normal Tissue Figure 6 Kidney

Collecting ducts Staining: Low Intensity: Moderate Quantity: <25% Distal tubules Staining: Low Intensity: Moderate Quantity: <25%

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/43/1054_A_7_5.jpg

Normal Tissue Figure 7 Breast

Glandular cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Myoepithelial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/20416/45831_B_3_4.jpg

RNA Expression Figure 8 RNA cell line category: Group enriched (OE19, SK-BR-3)

Cell lines ordered by descending RNA expression order

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000141736-ERBB2

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Specifications

Host Species
Human

Derivation
Phage display library

Type
Human antibody

Specificity
Human

Species Reactivity
Human

Applications
FC, Inhib, IF, Cyt, WB, Apop

Related Disease
ovarian carcinoma xenografts

Applications

Application Notes
The HER2/neu antibody has been reported in applications of Flow Cytometry, Inhibition, Immunofluorescence, Cytotoxicity, Western Blot, Apoptosis.

Target

Alternative Names
ERBB2; erb-b2 receptor tyrosine kinase 2; NEU; NGL; HER2; TKR1; CD340; HER-2; MLN 19; HER-2/neu; receptor tyrosine-protein kinase erbB-2; herstatin; p185erbB2; proto-oncogene Neu; c-erb B2/neu protein; proto-oncogene c-ErbB-2; metastatic lymph node gene 19 protein; human epidermal growth factor receptor 2; neuro/glioblastoma derived oncogene homolog; tyrosine kinase-type cell surface receptor HER2; neuroblastoma/glioblastoma derived oncogene homolog; v-erb-b2 avian erythroblastic leukemia viral oncoprotein 2; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2; v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog;

Gene ID
2064

UniProt ID
P04626

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Related Diseases

Bladder Cancer

Non-small Cell Lung Cancer

Related Signaling Pathways

ErbB Signaling Pathway

Downloadable Resources

Download resources about recombinant antibody development and antibody engineering to boost your research.

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

Datasheet - TAB-044CT.pdf

MSDS

MSDS - TAB-044CT.pdf

COA

Certificate of Analysis Lookup

To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.

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Protocol & Troubleshooting

Immunofluorescence (IF)

We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.

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AGTO-G022R	Anti-ERBB2 immunotoxin 4D5 (scFv)-RTA	Cytotoxicity assay, Function study
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CAT	Product Name	Application	Type
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HPAB-0608LY	Human Anti-ERBB2 Recombinant Antibody (HPAB-0608LY)	ELISA, Inhib, WB, FC	Humanized IgG1
HPAB-0609LY	Human Anti-ERBB2 Recombinant Antibody (HPAB-0609LY)	ELISA, Inhib	Humanized IgG1
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CAT	Product Name	Application	Type
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HPAB-0734LY-S(P)	Human Anti-ERBB2 Recombinant Antibody (clone A058); scFv Fragment	ELISA	Human scFv
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TAB-0191CL	Human Anti-ERBB2 Recombinant Antibody (TAB-0191CL)	ELISA, Cyt, Internalization	Human IgG
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TAB-0193CL	Human Anti-ERBB2 Recombinant Antibody (TAB-0193CL)	ELISA, ADCC, Cyt, Internalization	Human IgG
TAB-0194CL	Human Anti-ERBB2 Recombinant Antibody (TAB-0194CL)	ELISA, ADCC, Cyt, Internalization	Human IgG
TAB-0191CL-S(P)	Human Anti-ERBB2 Recombinant Antibody; scFv Fragment (TAB-0191CL-S(P))	ELISA, Cyt, Internalization	Human scFv

CAT	Product Name	Application	Type
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CAT	Product Name	Application	Type
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TAB-036CT-F(E)	Anti-Human HER2/neu Recombinant Antibody Fab Fragment (6B2)	ELISA, WB
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CAT	Product Name	Application	Type
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CAT	Product Name	Application	Type
Gly-145LC	Recombinant Anti-Human ERBB2 Antibody (Fc glycosylation)	ELISA	Human antibody
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Gly-147LC	Recombinant Anti-Human ERBB2 Antibody (Fc glycosylation)	ELISA	Human antibody
Gly-148LC	Recombinant Anti-Human ERBB2 Antibody (Fc glycosylation)	ELISA	Human antibody
Gly-149LC	Recombinant Anti-Human ERBB2 Antibody (Fc glycosylation)	ELISA	Human antibody

CAT	Product Name	Application	Type
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CAT	Product Name	Application	Type
BRD-0195MZ	Chicken Anti-ERBB2 Polyclonal IgY	WB	Chicken antibody

CAT	Product Name	Application	Type
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CAT	Product Name	Application	Type
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MOR-4587	Hi-Affi™ Rabbit Anti-ERBB2 Recombinant Antibody (clone TH100DS)	WB	Rabbit IgG

CAT	Product Name	Application
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MHC-LC2351	APC-A*02:01/Human ERBB2 (PLTSIISAV) MHC Tetramer	FCM
MHC-LC2498	PE-B*07:02/Human ERBB2 (LPQPPICTI) MHC Tetramer	FCM
MHC-YF049	DRB1*01:01/Human HER2 (KVPIKWMALESILRRRF) MHC Monomer	MHC Multimer
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HPAB-1111LY-F(E)	Mouse Anti-ERBB2 Recombinant Antibody; Fab Fragment (HPAB-1111LY-F(E))	ELISA	Mouse Fab
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HPAB-M0073-YC-F(E)	Human Anti-ERBB2 Recombinant Antibody; Fab Fragment (HPAB-M0073-YC-F(E))	ELISA, FC	Human Fab
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CAT	Product Name	Application	Type
VS-0125-FY24	Human Anti-ERBB2 (clone 1.18.1) scFv-Fc Chimera	FC, BI	Human IgG1, scFv-Fc

CAT	Product Name	Application	Type
VS-0225-XY108	CytoStream™ Mouse Anti-ERBB2 Recombinant Antibody (clone 24D2)	FC	Mouse IgG1, kappa

CAT	Product Name	Application	Type
VS-0425-YC430	Recombinant Anti-ERBB2 Vesicular Antibody, EV Displayed (VS-0425-YC430)	ELISA, FC, Neut, Cell-uptake

CAT	Product Name	Application	Type
VS-0525-XY2335	Anti-ERBB2 Immunohistochemistry Kit	IHC
VS-0525-XY2336	Anti-Mouse ERBB2 Immunohistochemistry Kit	IHC

CAT	Product Name	Application	Type
VS-0525-YC3	Recombinant Anti-ERBB2 Biparatopic Antibody, Symmetric scFv-Fab	ELISA	Symmetric scFv-Fab
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