Anti-Human HER2/neu Recombinant Antibody scFv Fragment (C6.5) (CAT#: TAB-040CT-S(P))
Recombinant monoclonal antibody to HER2/neu. This antibody intended for the prophylaxis and treatment of HER2-positive breast cancer.
Specific Inquiry
FC
-1.png)
Figure 1 C6.5db does not compete with trastuzumab for binding to HER2 in vitro.
Flow cytometry shows that pretreatment of SK-OV-3 and BT-474 cells with the anti-HER2 mAb trastuzumab does not block binding of the C6.5db to cells as compared with those pretreated with the anti-CD20 mAb rituximab.
Reddy, S., Shaller, C. C., Doss, M., Shchaveleva, I., Marks, J. D., Jian, Q. Y., & Robinson, M. K. (2011). Evaluation of the anti-HER2 C6. 5 diabody as a PET radiotracer to monitor HER2 status and predict response to trastuzumab treatment. Clinical Cancer Research, 17(6), 1509-1520.
IP
-2.png)
Figure 2 C6.5db does not compete with trastuzumab for binding to HER2 in vitro.
HER2 ECD-coupled agarose beads pretreated with saturating amount of trastuzumab precipitate C6.5db to equal levels as beads pretreated with either rituximab or PBS.
Reddy, S., Shaller, C. C., Doss, M., Shchaveleva, I., Marks, J. D., Jian, Q. Y., & Robinson, M. K. (2011). Evaluation of the anti-HER2 C6. 5 diabody as a PET radiotracer to monitor HER2 status and predict response to trastuzumab treatment. Clinical Cancer Research, 17(6), 1509-1520.
Block
-3.png)
Figure 3 C6.5db does not compete with trastuzumab for binding to HER2 in vitro.
Pretreating SK-OV-3 and BT-474 cells with either pertuzumab (D) or C6.5db (E) blocks the ability of the other antibody to bind to the cells. Shaded histogram, no primary antibody. DB, C6.5db; R, rituximab; T, trastuzumab; P, pertuzumab.
Reddy, S., Shaller, C. C., Doss, M., Shchaveleva, I., Marks, J. D., Jian, Q. Y., & Robinson, M. K. (2011). Evaluation of the anti-HER2 C6. 5 diabody as a PET radiotracer to monitor HER2 status and predict response to trastuzumab treatment. Clinical Cancer Research, 17(6), 1509-1520.
Specifications
- Host Species
- Human
- Derivation
- Phage display library
- Type
- Human antibody
- Specificity
- Human
- Species Reactivity
- Human
- Clone
- C6.5
- Applications
- FC, IP, Block
- Related Disease
- HER2-positive breast cancer
Applications
- Application Notes
- The HER2/neu antibody has been reported in applications of Flow Cytometry, Immunoprecipitation, Block.
Target
- Alternative Names
- ERBB2; erb-b2 receptor tyrosine kinase 2; NEU; NGL; HER2; TKR1; CD340; HER-2; MLN 19; HER-2/neu; receptor tyrosine-protein kinase erbB-2; herstatin; p185erbB2; proto-oncogene Neu; c-erb B2/neu protein; proto-oncogene c-ErbB-2; metastatic lymph node gene 19 protein; human epidermal growth factor receptor 2; neuro/glioblastoma derived oncogene homolog; tyrosine kinase-type cell surface receptor HER2; neuroblastoma/glioblastoma derived oncogene homolog; v-erb-b2 avian erythroblastic leukemia viral oncoprotein 2; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2; v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog;
- Gene ID
- 2064
- UniProt ID
- P04626
Related Resources
Bladder Cancer
Non-small Cell Lung Cancer
ErbB Signaling Pathway
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Single-domain Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NABG-059 | Recombinant Anti-Human ERBB2 VHH Single Domain Antibody | IHC, FC, CA, FuncS | Llama VHH |
| PNBL-066 | Recombinant Anti-HER2 VHH Single Domain Antibody (Gr3) | SPR | Llama VHH |
| PNBL-067 | Recombinant Anti-HER2 VHH Single Domain Antibody (Gr6) | SPR | Llama VHH |
| HPAB-1026WJ | Recombinant Camelid Anti-ERBB2 Single Domain Antibody | ELISA | Camelid VHH |
| HPAB-0725-YJ-VHH | Camelid Anti-ERBB2 Recombinant Single Domain Antibody (SR-87) | ELISA | Camelid VHH |
Intrabody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| IAB-B008(A) | Recombinant Anti-human ERBB2 Intrabody [(D-Arg)9] | IF, FC, FuncS | scFv-(D-Arg)9 |
| IAB-B008(G) | Recombinant Anti-human ERBB2 Intrabody [+36 GFP] | WB, ICC, FuncS | scFv-(+36GFP) |
| IAB-B008(T) | Recombinant Anti-human ERBB2 Intrabody [Tat] | ICC, Neut, FuncS | scFv-Tat |
Chimeric Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-761 | Anti-ERBB2 Recombinant Antibody (Margetuximab) | IF, IP, Neut, FuncS, ELISA, FC, WB | IgG1 - kappa |
| TAB-049CT | Anti-Human HER2/neu Recombinant Antibody (ChA21) | IHC, Inhib, WB, Activ, FC | Chimeric antibody (mouse/human) |
| TAB-049CT-S(P) | Anti-Human HER2/neu Recombinant Antibody scFv Fragment (ChA21) | WB | Chimeric antibody (mouse/human) |
| TAB-049CT-F(E) | Anti-Human HER2/neu Recombinant Antibody Fab Fragment (ChA21) | WB | Chimeric antibody (mouse/human) |
Immunotoxin
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AGTO-G022E | Anti-ERBB2 immunotoxin 4D5 (scFv)-PE | Cytotoxicity assay, Function study | |
| AGTO-G022D | Anti-ERBB2 immunotoxin 4D5 (scFv)-DT | Cytotoxicity assay, Function study | |
| AGTO-G022G | Anti-ERBB2 immunotoxin 4D5 (scFv)-Gel | Cytotoxicity assay, Function study | |
| AGTO-G022R | Anti-ERBB2 immunotoxin 4D5 (scFv)-RTA | Cytotoxicity assay, Function study | |
| AGTO-G022S | Anti-ERBB2 immunotoxin 4D5 (scFv)-Sap | Cytotoxicity assay, Function study |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBL-126 | Human Anti-ERBB2 Recombinant Antibody; Fab Fragment (PFBL-126) | ELISA, WB, FuncS | Human Fab |
| FAMAB-0098-YC-F(E) | Mouse Anti-ERBB2 Recombinant Antibody (clone E402); Fab Fragment | Cyt | Mouse Fab |
| FAMAB-0099-YC-F(E) | Human Anti-ERBB2 Recombinant Antibody (clone CH402); Fab Fragment | Cyt | Human Fab |
| HPAB-0010-FY-F(E) | Human Anti-ERBB2 Recombinant Antibody; Fab Fragment (HPAB-0010-FY-F(E)) | ELISA, FC | Human Fab |
| HPAB-0011-FY-F(E) | Mouse Anti-ERBB2 Recombinant Antibody; Fab Fragment (HPAB-0011-FY-F(E)) | Inhib | Mouse Fab |
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0191CL | Human Anti-ERBB2 Recombinant Antibody (TAB-0191CL) | ELISA, Cyt, Internalization | Human IgG |
| TAB-0192CL | Human Anti-ERBB2 Recombinant Antibody (TAB-0192CL) | ELISA, ADCC, Cyt, Internalization | Human IgG |
| TAB-0193CL | Human Anti-ERBB2 Recombinant Antibody (TAB-0193CL) | ELISA, ADCC, Cyt, Internalization | Human IgG |
| TAB-0193CL-F(E) | Human Anti-ERBB2 Recombinant Antibody; Fab Fragment (TAB-0193CL-F(E)) | ELISA, Cyt, Internalization | Human Fab |
| TAB-0194CL-F(E) | Human Anti-ERBB2 Recombinant Antibody; Fab Fragment (TAB-0194CL-F(E)) | ELISA, Cyt, Internalization | Human Fab |
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-034CT | Anti-Human HER2/neu Recombinant Antibody (pertuzumab ) | WB | |
| TAB-036CT | Anti-Human HER2/neu Recombinant Antibody (6B2) | ELISA, WB | |
| TAB-037CT | Anti-Human HER2/neu Recombinant Antibody (7C2/7F3) | ELISA, WB | |
| TAB-270CQ | Mouse Anti-ERBB2 Recombinant Antibody (TAB-270CQ) | WB, Inhib | Mouse IgG |
| PABX-082-S (P) | Recombinant Human Anti-HER2 Antibody scFv Fragment (Gr6) | WB, ELISA, FuncS | scFv |
Humanized Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-033CT-S(P) | Human Anti-ERBB2 Recombinant Antibody; scFv Fragment (TAB-033CT-S(P)) | ELISA, WB | Human scFv |
| TAB-038CT-S(P) | Human Anti-ERBB2 Recombinant Antibody; scFv Fragment (TAB-038CT-S(P)) | WB | Humanized scFv |
| TAB-039CT-S(P) | Anti-Human HER2/neu Recombinant Antibody scFv Fragment (h1E11) | WB | Humanized antibody |
| TAB-041CT-S(P) | Human Anti-ERBB2 Recombinant Antibody; scFv Fragment (TAB-041CT-S(P)) | ELISA, WB | Humanized scFv |
| TAB-041CT-F(E) | Human Anti-ERBB2 Recombinant Antibody; Fab Fragment (TAB-041CT-F(E)) | ELISA, WB | Humanized Fab |
Fab Glycosylation
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-024LC | Recombinant Anti-Human ERBB2 Antibody (Fab glycosylation) | ELISA | Mouse antibody |
| Gly-039LC | Recombinant Anti-Human ERBB2 Antibody (Fab glycosylation) | ELISA | Human antibody |
Fc Glycosylation
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-117LC | Recombinant Anti-Human ERBB2 Antibody (Fc glycosylation) | ELISA | Humanized antibody |
| Gly-118LC | Recombinant Anti-Human ERBB2 Antibody (Fc glycosylation) | ELISA | Mouse antibody |
| Gly-145LC | Recombinant Anti-Human ERBB2 Antibody (Fc glycosylation) | ELISA | Human antibody |
| Gly-146LC | Recombinant Anti-Human ERBB2 Antibody (Fc glycosylation) | ELISA | Human antibody |
| Gly-147LC | Recombinant Anti-Human ERBB2 Antibody (Fc glycosylation) | ELISA | Human antibody |
Deglycosylated Antibody (Non-glycosylated IgGs)
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-177LC | Recombinant Anti-Human ERBB2 Antibody (Non-glycosylated) | ELISA | Humanized antibody |
Chicken IgY Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0195MZ | Chicken Anti-ERBB2 Polyclonal IgY | WB | Chicken antibody |
| BRD-0695MZ | Chicken Anti-ERBB2 Polyclonal IgY | WB | Chicken antibody |
| BRD-0779MZ | Chicken Anti-ErbB2 Polyclonal IgY | ICC, IF, IHC, IP | Chicken antibody |
Blocking Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-737CQ | Mouse Anti-ERBB2 Recombinant Antibody (clone 7.16.4) | Block, IP, IF, FC | Mouse IgG2a |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1178 | Hi-Affi™ Rabbit Anti-ERBB2 Recombinant Antibody (clone DS1178AB) | IHC-P, IHC-Fr | Rabbit IgG |
| MOR-4586 | Hi-Affi™ Rabbit Anti-ERBB2 Recombinant Antibody (clone TH99DS) | WB | Rabbit IgG |
| MOR-4587 | Hi-Affi™ Rabbit Anti-ERBB2 Recombinant Antibody (clone TH100DS) | WB | Rabbit IgG |
MHC Tetramer for Cancer
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-014LC | Mouse Anti-ERBB2 Recombinant Antibody (MOB-014LC) | ELISA, FC | Mouse IgG |
| MOB-014LC-F(E) | Mouse Anti-ERBB2 Recombinant Antibody; Fab Fragment (MOB-014LC-F(E)) | ELISA, FC | Mouse Fab |
| MOB-014LC-S(P) | Mouse Anti-ERBB2 Recombinant Antibody; scFv Fragment (MOB-014LC-S(P)) | ELISA, FC | Mouse scFv |
| HPAB-0010-FY | Human Anti-ERBB2 Recombinant Antibody (HPAB-0010-FY) | ELISA, FC, ADCC | Human IgG1, κ |
| HPAB-0011-FY | Mouse Anti-ERBB2 Recombinant Antibody (HPAB-0011-FY) | Inhib, ADCC, FuncS | Mouse IgG1, κ |
ADCC Enhanced Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-468CQ | Afuco™ Anti-ERBB2 ADCC Recombinant Antibody (Timigutuzumab), ADCC Enhanced | ELISA, IHC, FC, IP, IF, FuncS | ADCC enhanced antibody |
| AFC-TAB-053 | Afuco™ Anti-ERBB2 ADCC Recombinant Antibody (Pertuzumab), ADCC Enhanced | FuncS, IF, Neut, ELISA, FC, IP | ADCC enhanced antibody |
| AFC-TAB-761 | Afuco™ Anti-ERBB2 ADCC Recombinant Antibody (Margetuximab), ADCC Enhanced | IF, IP, Neut, FuncS, ELISA, FC | ADCC enhanced antibody |
| AFC-TAB-005 | Afuco™ Anti-ERBB2 ADCC Recombinant Antibody (Trastuzumab), ADCC Enhanced | FC, IP, ELISA, Neut, FuncS, IF | ADCC enhanced antibody |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0170JF-S(P) | Human Anti-ERBB2 Recombinant Antibody (clone C6VLF); scFv Fragment | ELISA, FuncS | Human scFv |
| FAMAB-0171JF-S(P) | Human Anti-ERBB2 Recombinant Antibody (clone C6L1); scFv Fragment | ELISA, FuncS | Human scFv |
| FAMAB-0172JF-S(P) | Human Anti-ERBB2 Recombinant Antibody (clone C6H2); scFv Fragment | ELISA, FuncS | Human scFv |
| FAMAB-0173JF-S(P) | Human Anti-ERBB2 Recombinant Antibody (clone C6H211); scFv Fragment | ELISA, FuncS | Human scFv |
| FAMAB-0359JF-S(P) | Human Anti-ERBB2 Recombinant Antibody (clone FRc13); scFv Fragment | DB, ELISA, FuncS | Human scFv |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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