Anti-Human HER2/neu Recombinant Antibody scFv Fragment (C6.5) (CAT#: TAB-040CT-S(P))
Recombinant monoclonal antibody to HER2/neu. This antibody intended for the prophylaxis and treatment of HER2-positive breast cancer.
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FC
-1.png)
Figure 1 C6.5db does not compete with trastuzumab for binding to HER2 in vitro.
Flow cytometry shows that pretreatment of SK-OV-3 and BT-474 cells with the anti-HER2 mAb trastuzumab does not block binding of the C6.5db to cells as compared with those pretreated with the anti-CD20 mAb rituximab.
Reddy, S., Shaller, C. C., Doss, M., Shchaveleva, I., Marks, J. D., Jian, Q. Y., & Robinson, M. K. (2011). Evaluation of the anti-HER2 C6. 5 diabody as a PET radiotracer to monitor HER2 status and predict response to trastuzumab treatment. Clinical Cancer Research, 17(6), 1509-1520.
IP
-2.png)
Figure 2 C6.5db does not compete with trastuzumab for binding to HER2 in vitro.
HER2 ECD-coupled agarose beads pretreated with saturating amount of trastuzumab precipitate C6.5db to equal levels as beads pretreated with either rituximab or PBS.
Reddy, S., Shaller, C. C., Doss, M., Shchaveleva, I., Marks, J. D., Jian, Q. Y., & Robinson, M. K. (2011). Evaluation of the anti-HER2 C6. 5 diabody as a PET radiotracer to monitor HER2 status and predict response to trastuzumab treatment. Clinical Cancer Research, 17(6), 1509-1520.
Block
-3.png)
Figure 3 C6.5db does not compete with trastuzumab for binding to HER2 in vitro.
Pretreating SK-OV-3 and BT-474 cells with either pertuzumab (D) or C6.5db (E) blocks the ability of the other antibody to bind to the cells. Shaded histogram, no primary antibody. DB, C6.5db; R, rituximab; T, trastuzumab; P, pertuzumab.
Reddy, S., Shaller, C. C., Doss, M., Shchaveleva, I., Marks, J. D., Jian, Q. Y., & Robinson, M. K. (2011). Evaluation of the anti-HER2 C6. 5 diabody as a PET radiotracer to monitor HER2 status and predict response to trastuzumab treatment. Clinical Cancer Research, 17(6), 1509-1520.
Specifications
- Host Species
- Human
- Derivation
- Phage display library
- Type
- Human antibody
- Specificity
- Human
- Species Reactivity
- Human
- Clone
- C6.5
- Applications
- FC, IP, Block
- Related Disease
- HER2-positive breast cancer
Applications
- Application Notes
- The HER2/neu antibody has been reported in applications of Flow Cytometry, Immunoprecipitation, Block.
Target
- Alternative Names
- ERBB2; erb-b2 receptor tyrosine kinase 2; NEU; NGL; HER2; TKR1; CD340; HER-2; MLN 19; HER-2/neu; receptor tyrosine-protein kinase erbB-2; herstatin; p185erbB2; proto-oncogene Neu; c-erb B2/neu protein; proto-oncogene c-ErbB-2; metastatic lymph node gene 19 protein; human epidermal growth factor receptor 2; neuro/glioblastoma derived oncogene homolog; tyrosine kinase-type cell surface receptor HER2; neuroblastoma/glioblastoma derived oncogene homolog; v-erb-b2 avian erythroblastic leukemia viral oncoprotein 2; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2; v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog;
- Gene ID
- 2064
- UniProt ID
- P04626
Related Resources
Bladder Cancer
Non-small Cell Lung Cancer
ErbB Signaling Pathway
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| IAB-B008(A) | Recombinant Anti-human ERBB2 Intrabody [(D-Arg)9] | IF, FC, FuncS | scFv-(D-Arg)9 |
| IAB-B008(G) | Recombinant Anti-human ERBB2 Intrabody [+36 GFP] | WB, ICC, FuncS | scFv-(+36GFP) |
| IAB-B008(T) | Recombinant Anti-human ERBB2 Intrabody [Tat] | ICC, Neut, FuncS | scFv-Tat |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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