Recombinant Human Anti-HER2 Antibody Fab Fragment (Gr3 ) (CAT#: PABX-081-F (E))
Anti-HER2 antibody is a Human of Fab class that binds to an HER2. It developed From a synthetic human V (H) phage display library.
Specific Inquiry
-1.png)
Figure 1 Binding of Gr3 and Gr6 to HER2/Fc analyzed by SPR.
Baral, T. N., Chao, S. Y., Li, S., Tanha, J., Arbabi-Ghahroudi, M., Zhang, J., & Wang, S. (2012). Crystal structure of a human single domain antibody dimer formed through VH-VH non-covalent interactions. PloS one, 7(1), e30149.
-2.png)
Figure 2 Melting temperature (Tm) measurements of Gr3 and Gr6 by CD spectroscopy.
Melting temperature (Tm) measurements of Gr3 and Gr6 by CD spectroscopy. The CD values measured at 217 nm
are plotted against temperature ranging from 25uC to 91uC.
line shows the fitted values using
Baral, T. N., Chao, S. Y., Li, S., Tanha, J., Arbabi-Ghahroudi, M., Zhang, J., & Wang, S. (2012). Crystal structure of a human single domain antibody dimer formed through VH-VH non-covalent interactions. PloS one, 7(1), e30149.
-3.png)
Figure 3 Characterization of Gr3 and Gr6 in solution.
Size exclusion chromatography of IMAC-purified Gr3 and Gr6 using a SuperdexTM 75
column.
Baral, T. N., Chao, S. Y., Li, S., Tanha, J., Arbabi-Ghahroudi, M., Zhang, J., & Wang, S. (2012). Crystal structure of a human single domain antibody dimer formed through VH-VH non-covalent interactions. PloS one, 7(1), e30149.
Specifications
- Immunogen
- The details of the immunogen for this antibody are not available.
- Host Species
- Human
- Derivation
- Human
- Type
- Fab
- Specificity
- Tested positive against native Human HER2
- Species Reactivity
- Human
- Clone
- Gr3
- Applications
- WB 1:1000-1:5000
ELISA 1:10000-1:20000
FuncS (assay dependent)
Product Property
- Purity
- >95% by SDS-PAGE and HPLC analysis
- Storage
- Store the antibody (in aliquots) at -20°C. Avoid repeated freezing and thawing of samples.
Applications
- Application Notes
- Assay-depended
Target
- Alternative Names
- ERBB2; erb-b2 receptor tyrosine kinase 2; NEU; NGL; HER2; TKR1; CD340; HER-2; MLN 19; HER-2/neu; receptor tyrosine-protein kinase erbB-2; herstatin; p185erbB2; proto-oncogene Neu; c-erb B2/neu protein; proto-oncogene c-ErbB-2; metastatic lymph node gene 19 protein; human epidermal growth factor receptor 2; neuro/glioblastoma derived oncogene homolog; tyrosine kinase-type cell surface receptor HER2; neuroblastoma/glioblastoma derived oncogene homolog; v-erb-b2 avian erythroblastic leukemia viral oncoprotein 2; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2; v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog
- Gene ID
- 2064
- UniProt ID
- P04626
Related Resources
Bladder Cancer
Non-small Cell Lung Cancer
ErbB Signaling Pathway
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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Antibody Magnetic Beads
| CAT | Product Name | Application | Type |
|---|---|---|---|
| IAB-B008(A) | Recombinant Anti-human ERBB2 Intrabody [(D-Arg)9] | IF, FC, FuncS | scFv-(D-Arg)9 |
| IAB-B008(G) | Recombinant Anti-human ERBB2 Intrabody [+36 GFP] | WB, ICC, FuncS | scFv-(+36GFP) |
| IAB-B008(T) | Recombinant Anti-human ERBB2 Intrabody [Tat] | ICC, Neut, FuncS | scFv-Tat |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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