Anti-Human HER2/neu Recombinant Antibody (pertuzumab ) (CAT#: TAB-034CT)
Recombinant monoclonal antibody to HER2/neu. This antibody intended for the prophylaxis and treatment of Gastric cancers, Breast cancers .
Specific Inquiry
Figure 1 shows a plot of BT-474 in vitro cell viability at 5 days versus various fixed doses of pertuzumab in combination with dose response of trastuzumab-MCC-DM1 (T-DM1), and various doses of T-DM1 alone.
Figure 2 shows a plot of the in vivo mean tumor volume change over time in KPL-4 tumors inoculated into the mammary fat pad of SCID beige mice.
(1) ADC buffer, (2) pertuzumab 15 mg/kg, (3) T-DM1 0.3 mg/kg, (4) T-DM1 1 mg/kg, (5) T-DM1 3 mg/kg, (6) pertuzumab 15 mg/kg + T-DM1 0.3 mg, (7) pertuzumab 15 mg/kg + T-DM1 1 mg/kg, (8) pertuzumab 15 mg/kg + T-DM1 3 mg/kg. ADC buffer and T-DM1 were dosed once on day 0. Pertuzumab was dosed on days 0, 7, and 14.
Figure 3 depicts activity of Pertuzumab (Batch anti2C4907-2) in the antibody-dependent cell-mediated cytotoxicity (ADCC) assay.
Figure 4 depicts impact of G0-F level on ADCC activity. Samples tested were phase III Pertuzumab (G0-F = 2.2%) and phase I Pertuzumab (G0-F = 0.8%).
Specifications
- Host Species
- Mouse
- Specificity
- Human
- Species Reactivity
- Human
- Clone
- pertuzumab
- Applications
- FuncS, Cyt, WB
- Related Disease
- Gastric cancers, Breast cancers
Applications
- Application Notes
- The antibody was validated for Cytotoxicity and Function assay. For details, refer to Published Data.
Target
- Alternative Names
- ERBB2; erb-b2 receptor tyrosine kinase 2; NEU; NGL; HER2; TKR1; CD340; HER-2; MLN 19; HER-2/neu; receptor tyrosine-protein kinase erbB-2; herstatin; p185erbB2; proto-oncogene Neu; c-erb B2/neu protein; proto-oncogene c-ErbB-2; metastatic lymph node gene 19 protein; human epidermal growth factor receptor 2; neuro/glioblastoma derived oncogene homolog; tyrosine kinase-type cell surface receptor HER2; neuroblastoma/glioblastoma derived oncogene homolog; v-erb-b2 avian erythroblastic leukemia viral oncoprotein 2; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2; v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog;
- Gene ID
- 2064
- UniProt ID
- P04626
Related Resources
Please refer to Pertuzumab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Pertuzumab.
Bladder Cancer
Non-small Cell Lung Cancer
ErbB Signaling Pathway
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Intrabody
Chimeric Antibody
Immunotoxin
Fab Fragment Antibody
Humanized Antibody
Mouse Antibody
Human Antibody
Fab Glycosylation
Fc Glycosylation
Deglycosylated Antibody (Non-glycosylated IgGs)
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Blocking Antibody
Rabbit Monoclonal Antibody
MHC Tetramer for Cancer
Recombinant Antibody
Single-domain Antibody
ADCC Enhanced Antibody
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| IAB-B008(A) | Recombinant Anti-human ERBB2 Intrabody [(D-Arg)9] | IF, FC, FuncS | scFv-(D-Arg)9 |
| IAB-B008(G) | Recombinant Anti-human ERBB2 Intrabody [+36 GFP] | WB, ICC, FuncS | scFv-(+36GFP) |
| IAB-B008(T) | Recombinant Anti-human ERBB2 Intrabody [Tat] | ICC, Neut, FuncS | scFv-Tat |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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