Recombinant Rabbit Anti-FAS Antibody (clone R02-8I7) (CAT#: VS3-FY535)
This product is a recombinant rabbit antibody that recognizes FAS. This antibody has been reported for use in Western Blot, Immunohistochemistry-Frozen, Immunohistochemistry-Paraffin, Immunocytochemistry, Immunofluorescence. The clone R02-8I7 is specific for human FAS. The antigen is human fas synthetic peptide.
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WB
Figure 1. Recombinant Rabbit Anti-FAS Antibody (clone R02-8I7) in WB.
Western Blot analysis of Fas in Hela, Jurkat lysates using Fas Antibody.
Specifications
- Immunogen
- Human Fas Synthetic Peptide.
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human FAS
- Species Reactivity
- Human
- Clone
- R02-8I7
- Applications
- Western Blot, Immunohistochemistry-Frozen, Immunohistochemistry-Paraffin, Immunocytochemistry, Immunofluorescence
- Conjugate
- Unconjugated
- MW
- Calculated MW: 38 kDa; Observed MW: 40-50 kDa
Product Property
- Purification
- Affinity Purified
- Purity
- >95% as determined by SDS-PAGE
- Buffer
- 50 mM Tris-Glycine, pH 7.4, 0.15 M NaCl, 40% glycerol, 0.05% BSA
- Preservative
- 0.01% Sodium azide
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Western Blot: 1/500-1/1000
Immunohistochemistry-Paraffin: 1/50-1/100
Immunofluorescence: 1/50-1/200
Target
- Alternative Names
- Fas Cell Surface Death Receptor; Tumor Necrosis Factor Receptor Superfamily, Member 6; Fas (TNF Receptor Superfamily, Member 6); Apoptosis-Mediating Surface Antigen FAS; TNF Receptor Superfamily Member 6; FASLG Receptor; CD95 Antigen; TNFRSF6; APT1; FAS1; Mutant Tumor Necrosis Receptor Superfamily Member 6
- Gene ID
- 355
- UniProt ID
- P25445
- Cellular Localization
- Cell membrane, Membrane, Secreted
- Post Translation Modifications
- (Microbial infection) Glycosylated at Arg-250 by enteropathogenic E.coli protein NleB1: arginine GlcNAcylation prevents homotypic/heterotypic death domain interactions.
Palmitoylated (PubMed:25301068).
Palmitoylation by ZDHHC7 prevents the lysosomal degradation of FAS regulating its expression at the plasma membrane (PubMed:25301068).
N- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans.
- Protein Refseq
- NP_000034.1; NP_001307548.1; NP_690610.1
- Function
- Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro).
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Extracellular Vesicle (EV) Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABL-094 | Human Anti-FAS Recombinant Antibody (clone HFE7A) | ELISA, WB, IF, FuncS | Human IgG |
| MOB-252YJL | Rabbit Anti-FAS Recombinant Antibody (clone CBF237) | FC, ICC, IF | Rabbit IgG |
| HPAB-1575WJ | Mouse Anti-FAS Recombinant Antibody (clone F919-9-18) | ELISA, WB | Mouse IgG |
| ZG-0333J | Mouse Anti-FAS Recombinant Antibody (ZG-0333J) | WB | Mouse IgG |
| ZG-0334J | Mouse Anti-FAS Recombinant Antibody (ZG-0334J) | WB | Mouse IgG |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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