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UTS2

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This gene encodes a mature peptide that is an active cyclic heptapeptide absolutely conserved from lamprey to human. The active peptide acts as a vasoconstrictor and is expressed only in brain tissue. Despite the gene family name similarity, this gene is not homologous to urocortin, a member of the sauvagine/corticotropin-releasing factor/urotensin I family. Most of the proprotein is cleaved to make the mature peptide. Transcript variants encoding different preproprotein isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Predicted location

Intracellular, Secreted (different isoforms)

Single cell type specificity

Cell type enhanced (NK-cells, granulocytes, T-cells, monocytes, dendritic cells)

Immune cell specificity

Immune cell enriched (T-reg)

Cell line specificity

Cell line enhanced (CACO-2, HEL, HMC-1, THP-1)

Molecular function

Hormone

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More Infomation

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For Research Use Only. Not For Clinical Use.

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