Human Anti-IL2RA Recombinant Antibody (clone CHI621) (CAT#: PABZ-020)

Recombinant Chimeric (Human/Mouse) Antibody (CHI621) is capable of binding to CD25, expressed in Chinese Hamster Ovary cells (CHO). This chimeric antibody (SDZ CHI621) has been evaluated in a phase I/II clinical study in human renal cadaver transplantation and has shown very promising results.


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  • Published Data
  • Gene Expression
  • Datasheet
  • MSDS
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Figure 1 Effect of chRFT5 on lymphocytes, subsets, and activated T cells.

Figure 1 Effect of chRFT5 on lymphocytes, subsets, and activated T cells.

(A) Lymp = lymphocytes; NK = natural killer cells (CD16+CD17+); TCRαβ = T cells with αβ T cell receptor; TCRδ = T cells with γδ T cell receptor. (B) ** P<0.0001 (Student's t test on paired columns); chRFT5 absent in vivo: open squares; chRFT5 present in vivo: black squares. Mean for each of 18 patients was obtained from an average of 4.5 (range 2-8; chRFT5 absent) and 12.8 (range 6-19; chRFT5 present) evaluations per patient. Abbreviations: chRFT5, chimeric RFT5 (CD25) (SDZ CHI 621).

Amlot, P. L., Rawlings, E., Fernando, O. N., Griffin, P. J., Heinrich, G., Schreier, M. H., ... & Sweny, P. (1995). Prolonged action of a chimeric interleukin-2 receptor (CD25) monoclonal antibody used in cadaveric renal transplantation. Transplantation, 60(7), 748-756.


Specifications

  • Immunogen
  • Human interleukin 2 receptor subunit alpha
  • Host Species
  • Human
  • Derivation
  • Chimeric (mouse/human)
  • Type
  • Chimeric (mouse/human) IgG
  • Specificity
  • Human IL2RA
  • Species Reactivity
  • Human
  • Clone
  • CHI621
  • Applications
  • Block

Product Property

  • Purity
  • >95% as determined by SDS-PAGE and HPLC analysis
  • Concentration
  • Please refer to the vial label for the specific concentration.
  • Storage
  • Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Applications

  • Application Notes
  • The antibody CHI621 has been reported in applications of FuncS, Block. It's recommended that the optimal antibody concentration, dilution, incubition time etc. are best to be carefully titrated in specific assays.

Target

  • Alternative Names
  • p55; CD25; IL2R; IMD41; TCGFR; IDDM10

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

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See other products for "Clone CHI621"

See other products for "IL2RA"

Intrabody

CAT Product Name Application Type
IAB-B073(A) Recombinant Anti-human IL2RA Intrabody [(D-Arg)9] IF, ELISA, FuncS scFv-(D-Arg)9
IAB-B073(G) Recombinant Anti-human IL2RA Intrabody [+36 GFP] IF, FC, WB, FuncS scFv-(+36GFP)
IAB-B073(T) Recombinant Anti-human IL2RA Intrabody [Tat] WB, CO-IP, FuncS scFv-Tat

Chimeric Antibody

Immunotoxin

CAT Product Name Application Type
AGTO-L027D anti-IL2RA immunotoxin RFT5 (scFv)-DT Cytotoxicity assay, Functional assay
AGTO-L027R anti-IL2RA immunotoxin RFT5 (scFv)-RTA Cytotoxicity assay, Functional assay
AGTO-L078E IL2-PE immunotoxin Cytotoxicity assay, Functional assay
AGTO-L078D IL2-DT immunotoxin Cytotoxicity assay, Functional assay
AGTO-L078R IL2-RTA immunotoxin Cytotoxicity assay, Functional assay

Neutralizing Antibody

Blocking Antibody

CAT Product Name Application Type
NEUT-1350CQ Mouse Anti-IL2RA Recombinant Antibody (clone 2R12) Block, FC, ICC, IF, IHC, IP, WB Mouse IgG1
NEUT-1356CQ Rat Anti-Il2ra Recombinant Antibody (VMC199) FC, IP, IHC, Block, Depletion Rat IgG1, λ
NEUT-1357CQ Rat Anti-Il2ra Recombinant Antibody (clone 3C7) FC, IP, Inhib Rat IgG2b, κ
NEUT-1358CQ Rat Anti-Il2ra Recombinant Antibody (clone mAb0817) Block, Depletion Rat IgG1
NEUT-1359CQ Rat Anti-Il2ra Recombinant Antibody (clone mAb0845) Block, FC, IHC-Fr, IP Rat IgG1

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-1808 Rabbit Anti-IL2RA Recombinant Antibody (clone DS1808AB) IHC, ICC, IP Rabbit IgG

Recombinant Antibody

CAT Product Name Application Type
FAMAB-0197CQ Mouse Anti-IL2RA Recombinant Antibody (clone 2C8) ELISA, WB, FC Mouse IgG1, κ
FAMAB-0198CQ Human Anti-IL2RA Recombinant Antibody (clone 4C1) ELISA, WB, FC Chimeric (mouse/human) IgG1, κ
FAMAB-0199CQ Mouse Anti-IL2RA Recombinant Antibody (clone 4F8) ELISA, WB, FC Mouse IgG2a, κ
FAMAB-0200CQ Human Anti-IL2RA Recombinant Antibody (clone huD1) ELISA, FC, Block Humanized IgG1, κ
FAMAB-0201CQ Mouse Anti-IL2RA Recombinant Antibody (clone D1) ELISA, FC, Block Mouse IgG2a, κ

ADCC Enhanced Antibody

CAT Product Name Application Type
AFC-TAB-004 Afuco™ Anti-IL2RA ADCC Recombinant Antibody (Basiliximab), ADCC Enhanced IF, IP, Neut, FuncS, ELISA, FC ADCC enhanced antibody
AFC-TAB-023 Afuco™ Anti-IL2RA ADCC Recombinant Antibody (Daclizumab), ADCC Enhanced ELISA, Neut, IF, IP, FC, FuncS ADCC enhanced antibody
AFC-TAB-155 Afuco™ Anti-IL2RA ADCC Recombinant Antibody (Inolimomab), ADCC Enhanced IP, IF, FuncS, FC, Neut, ELISA ADCC enhanced antibody

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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