Mouse Anti-ERBB3 Recombinant Antibody (clone 1153) (CAT#: HPAB-0286-YC)
erbB3 is a single pass type transmembrane protein which belongs to epidermal growth factor receptor (EGFR) family. The product herein is an antibody which recognizes the domain 1 in the extracellular domain of erbB3 and inhibit EGF-like ligand-dependent phosphorylation of erbB3.
Specific Inquiry
FuncS
Figure 1 shows the combinational effect of the anti-human erbB3 antibody in the human breast cancer cell line T47D-grafted mouse model
"X" indicates an anti-DNP antibody as a control, "□" indicates a 1153 antibody, "♦" indicates a 1126 antibody, and "∘" indicates a 1153+1126 combination antibody (combination antibody of a 1153 antibody and a 1126 antibody). The abscissa shows the number of days after the tumor grafting, and the ordinate shows the tumor volume.
FuncS
Figure 2 shows combinational effect of the anti-human erbB3 antibodies in the human squamous carcinoma cell line A431-grafted mouse model.
"□" indicates an anti-DNP antibody as a control, "♦" indicates a 1153+1251 combination antibody (combination antibody of a 1153 antibody and a 12511 antibody), "∘" indicates a 12511+1126 combination antibody (combination antibody of a 12511 antibody and a 1126 antibody), and "X" indicates a 1153+1126 combination antibody (combination antibody of a 1153 antibody and a 1126 antibody). The abscissa shows the number of days after the tumor grafting, and the ordinate shows the tumor volume.
Specifications
- Immunogen
- ErbB3-Fc
- Host Species
- Mouse
- Type
- Mouse IgG
- Specificity
- Human ERBB3
- Species Reactivity
- Human
- Clone
- 1153
- Applications
- ELISA, FuncS, FC
- Related Disease
- Cancer
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- The antibody was validated for Enzyme-linked Immunosorbent Assay, Flow Cytometry, and Functional Assay. For details, refer to Published Data.
Target
- Alternative Names
- Erb-B2 Receptor Tyrosine Kinase 3; V-Erb-B2 Avian Erythroblastic Leukemia Viral Oncogene Homolog 3; Tyrosine Kinase-Type Cell Surface Receptor HER3; Human Epidermal Growth Factor Receptor 3; Proto-Oncogene-Like Protein C-ErbB-3; EC 2.7.10.1; HER3; Lethal Congenital Contracture Syndrome 2; P180-ErbB3; P45-SErbB3; P85-SErbB3; EC 2.7.10; MDA-BF-1; C-ErbB-3; C-ErbB3; ErbB3-S; ErbB-3; LCCS2
- Gene ID
- 2065
- UniProt ID
- P21860
Related Resources
EGFR Tyrosine Kinase Inhibitor Resistance
ErbB Signaling Pathway
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Single-domain Antibody
Human Antibody
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Immunotoxin
Mouse Antibody
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Neutralizing Antibody
Rabbit Monoclonal Antibody
Fab Fragment Antibody
ADCC Enhanced Antibody
scFv Fragment Antibody
Antibody Magnetic Beads
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NAB-1729-sdAb | Recombinant Anti-human ERBB3 VHH Single Domain Antibody | WB, ICC, ChiP, FA, ELISA | Llama VHH |
| TAB-070CT | Llama Anti-ERBB3 Recombinant Single Domain Antibody (TAB-070CT) | FC, Block | Llama VHH |
| PABC-556 | Recombinant Llama Anti-ERBB3 Single Domain Antibody (PABC-556) | ELISA, SPR | Llama VHH |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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