Anti-Human NTRK1 Recombinant Antibody Fab Fragment (CRB0089)
CAT#: TAB-511MZ-F(E)
This anti-TrkA antibody is able to recognise and binds NGF-binding site of the high affinity tyrosine kinase receptor of NGF (TrkA), thus acting as NGF antagonists and preventing the functional activation of TrkA by NGF. It also is useful in the treatment of conditions associated with the expression and activity of TrkA, including pain states.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line SH-SY5Y
Immunofluorescent staining of human cell line SH-SY5Y shows localization to cytosol & vesicles.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/76570/1680_E8_5_selected.jpg
Subcellular Location
Figure 2 IHC staining of human cerebral cortex
Immunohistochemical staining of human cerebral cortex shows moderate cytoplasmic positivity in neuronal cells.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/35799/ihc_selected.jpg
Subcellular Location
Figure 3 IHC staining of human cerebellum
Immunohistochemical staining of human cerebellum shows strong cytoplasmic positivity in purkinje cells.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4606/ihc_selected.jpg
Normal Tissue
Figure 4 Cerebral cortex
Glial cells
Staining:
Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/
membranous
Neuronal cells
Staining:
Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/35799/129189_B_9_5.jpg
Normal Tissue
Figure 5 Colon
Glandular cells
Staining:
Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/35799/129189_A_9_3.jpg
Normal Tissue
Figure 6 Testis
Elongated or late spermatids
Staining:
Medium
Intensity: Moderate
Quantity:>75%
Pachytene spermatocytes
Staining:
Medium
Intensity: Moderate
Quantity: 75%-25%
Round or early spermatids
Staining:
Medium
Intensity: Moderate
Quantity:>75%
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/35799/129189_A_6_6.jpg
RNA Expression
Figure 7 RNA cell line category: Cell line enriched (HMC-1)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000198400-NTRK1
❮
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Specifications
- Host Species
- Human
- Type
- Human antibody
- Specificity
- Human
- Clone
- CRB0089
- Applications
- Enzyme-linked Immunosorbent Assay, Western blot, Flow Cytometry
- Related Disease
- Inflammatory pain
Target
- Alternative Names
- NTRK1; neurotrophic tyrosine kinase, receptor, type 1; MTC; TRK; TRK1; TRKA; Trk-A; p140-TrkA; high affinity nerve growth factor receptor; gp140trk; Oncogene TRK; tyrosine kinase receptor A; tropomyosin-related kinase A; TRK1-transforming tyrosine kinase protein
- Gene ID
- 4914
- UniProt ID
- P04629
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Related Diseases
EGFR Tyrosine Kinase Inhibitor Resistance
Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
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- CAT
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-170CQ | Human Anti-Human NTRK1 Recombinant Antibody (CRB0089) | ELISA, FC, WB | Human antibody |
| TAB-170CQ-S(P) | Human Anti-Human NTRK1 Recombinant Antibody scFv Fragment (CRB0089) | ELISA, FC, WB | Human antibody |
| TAB-170CQ-F(E) | Human Anti-Human NTRK1 Recombinant Antibody Fab Fragment (CRB0089) | ELISA, FC, WB | Human antibody |
| TAB-511MZ | Anti-Human NTRK1 Recombinant Antibody (CRB0089) | ELISA, WB, FC | Human antibody |
| TAB-511MZ-S(P) | Anti-Human NTRK1 Recombinant Antibody scFv Fragment (CRB0089) | ELISA, WB, FC | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0759MZ | Chicken Anti-TrkA Polyclonal IgY | ELISA, IHC, IP, WB | Chicken antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABX-182 | Recombinant Mouse Anti-TrkA Antibody (MNAC13) | Neut, FuncS | IgG |
| PABX-182-S (P) | Recombinant Mouse Anti-TrkA Antibody scFv Fragment (MNAC13) | Neut, FuncS | scFv |
| PABX-182-F (E) | Recombinant Mouse Anti-TrkA Antibody Fab Fragment (MNAC13) | Neut, FuncS | Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2508 | Hi-Affi™ Recombinant Rabbit Anti-NTRK1 Monoclonal Antibody (DS2508AB) | WB, IHC | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0396-CN-S(P) | Human Anti-NTRK1 Recombinant Antibody scFv Fragment (HPAB-0396-CN-S(P)) | ELISA, Block | Human scFv |
| HPAB-0397-CN-S(P) | Human Anti-NTRK1 Recombinant Antibody scFv Fragment (HPAB-0397-CN-S(P)) | ELISA, Block | Human scFv |
| HPAB-0728-CN-S(P) | Mouse Anti-NTRK1 Recombinant Antibody (clone CRB0022); scFv Fragment | WB, ELISA, FC | Mouse scFv |
| HPAB-0729-CN-S(P) | Human Anti-NTRK1 Recombinant Antibody (clone CRB0088); scFv Fragment | WB, ELISA, FC | Human scFv |
| HPAB-0730-CN-S(P) | Human Anti-NTRK1 Recombinant Antibody (clone CRB0089_IgG4); scFv Fragment | WB, ELISA, FC | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0396-CN-F(E) | Human Anti-NTRK1 Recombinant Antibody Fab Fragment (HPAB-0396-CN-F(E)) | ELISA, Block | Human Fab |
| HPAB-0397-CN-F(E) | Human Anti-NTRK1 Recombinant Antibody Fab Fragment (HPAB-0397-CN-F(E)) | ELISA, Block | Human Fab |
| HPAB-1359-FY-S(P) | Human Anti-NTRK1 Recombinant Antibody; scFv Fragment (HPAB-1359-FY-S(P)) | ELISA | Humanized scFv |
| HPAB-1360-FY-S(P) | Human Anti-NTRK1 Recombinant Antibody; scFv Fragment (HPAB-1360-FY-S(P)) | ELISA | Humanized scFv |
| HPAB-AP400-YC-F(E) | Human Anti-NTRK1 Recombinant Antibody (clone CRB0036); Fab Fragment | ELISA, FC, WB, Inhib | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0728-CN | Mouse Anti-NTRK1 Recombinant Antibody (clone CRB0022) | WB, ELISA, FC | Mouse IgG |
| HPAB-0729-CN | Human Anti-NTRK1 Recombinant Antibody (clone CRB0088) | WB, ELISA, FC | Human IgG |
| HPAB-0730-CN | Human Anti-NTRK1 Recombinant Antibody (clone CRB0089_IgG4) | WB, ELISA, FC | Human IgG4 |
| HPAB-AP400-YC | Human Anti-NTRK1 Recombinant Antibody (clone CRB0036) | ELISA, FC, WB, Inhib | Human IgG |
| HPAB-AP401-YC | Human Anti-NTRK1 Recombinant Antibody (clone CRB0069) | ELISA, FC, WB, Inhib | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0424-XY207 | AbPlus™ Anti-NTRK1 Magnetic Beads (CBACN-560) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS13-YC846 | CytoStream™ Rabbit Anti-NTRK1 Recombinant Antibody (VS13-YC846) | WB, ICC, IF, IHC-P, IP, FC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC380 | Recombinant Anti-NTRK1 Vesicular Antibody, EV Displayed (VS-0425-YC380) | ELISA, FC, Neut, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY5016 | Anti-NTRK1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY5017 | Anti-Mouse NTRK1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY5018 | Anti-Rat NTRK1 Immunohistochemistry Kit | IHC |
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