In particular, how does gatipuzumab interact with the MUC1 antigen in cancerous cells?

Targeted by gatipuzumab, the MUC1 antigen's variable region is overexpressed in a large number of epithelial malignancies. It attaches itself to the protein in its hypoglycosylated form, facilitating efficient identification and remedial action.

In which types of cancers has Gatipotuzumab shown the most efficacy in clinical trials?

In clinical trials, gemcitabine has demonstrated exceptional efficacy against non-small cell lung cancer, ovarian cancer, and breast cancer. Tumor shrinkage and higher survival rates are evidence of its effectiveness.

Is it possible to combine gatipotuzumab with other forms of treatment?

Indeed, in order to improve therapeutic results, intratuzumab is frequently used in conjunction with radiation, chemotherapy, or other monoclonal antibodies. Patient response rates have improved with such combo medicines.

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MUC1
Anti-Human MUC1 Recombinant Antibody (TAB-026ML)

Anti-Human MUC1 Recombinant Antibody (TAB-026ML) (CAT#: TAB-026ML)

Recombinant monoclonal antibody to MUC1. It is a human monoclonal antibody that can be potentially used in the treatment of Solid tumors.

Tested Data
Gene Expression
Datasheet
MSDS
COA

SDS-PAGE

Figure 1 Anti-Human MUC1 Recombinant Antibody (TAB-026ML) in SDS-PAGE

Figure 1 Anti-Human MUC1 Recombinant Antibody (TAB-026ML) in SDS-PAGE

SDS-PAGE analysis of TAB-026ML in reduced (Lane 1) and non-reduced (Lane 2) conditions.

SEC-HPLC

Figure 2 Anti-Human MUC1 Recombinant Antibody (TAB-026ML) in HPLC

Figure 2 Anti-Human MUC1 Recombinant Antibody (TAB-026ML) in HPLC

The purity of TAB-026ML was greater than 95% as determined by SEC-HPLC.

Subcellular Location and Protein Expression

Figure 1 IF staining of human cell line RPTEC TERT1
(Immunofluorescent staining of human cell line RPTEC TERT1 shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/8855/1789_B9_13_cr596f381e20667_selected.jpg

Figure 2 IHC staining of human stomach
(Immunohistochemical staining of human stomach shows strong membranous positivity in glandular cells.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1986/ihc_selected.jpg

Figure 3 IF staining of human cell line A-431
(Immunofluorescent staining of human cell line A-431 shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/8855/100_E7_1_blue_red_green.jpg

Figure 4 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/8855/101_E7_1_blue_red_green.jpg

Normal Tissue

Figure 5 Stomach
(Glandular cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/36/155175_A_2_1.jpg

Figure 6 Colon
(Endocrine cells
Staining:High
Intensity: Strong
Enterocytes
Staining:High
Intensity: Strong
Quantity: 75%-25%
Goblet cells
Staining:High
Intensity: Strong
Quantity:>75%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/36/155175_A_9_3.jpg

Figure 7 Kidney
(Collecting ducts
Staining:High
Intensity: Strong
Quantity:>75%
Distal tubules
Staining:High
Intensity: Strong
Quantity:>75%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/36/155175_A_8_5.jpg

Figure 8 Testis
(Elongated or late spermatids
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/36/155175_A_6_6.jpg

RNA Expression

Figure 9 RNA cell line category: Group enriched (CAPAN-2, OE19, RPTEC TERT1, T-47d)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000185499-MUC1

Datasheet

Certificate of Analysis Lookup
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number

Specifications

Immunogen
The details of the immunogen for this antibody are not available.

Host Species
Human

Derivation
Humanized

Type
IgG1, κ

Specificity
Human MUC1

Species Reactivity
Human

Applications
ELISA, IHC, FC, IP, IF, FuncS, Stim

Conjugate
Unconjugated

Related Disease
Solid tumors

Product Property

Purity
> 95% as determined by SDS-PAGE

Storage
Store at -20°C for long-term storage. Avoid freeze/thaw cycles.

Applications

Application Notes
The MUC1 antibody has been reported in applications of ELISA, IHC, FC, IP, IF, FuncS, Stim.

Target

Alternative Names
Mucin 1; polymorphic epithelial mucin; PEM; episialin; CD227

Gene ID
4582

UniProt ID
P15941

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

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CAT	Product Name	Application	Type
NAB-2049-VHH	Recombinant Anti-human MUC1 VHH Single Domain Antibody	WB, IP, ChiP, Neut, ELISA	Llama VHH
HPAB-AP504-YC	Recombinant Camel Anti-MUC1 Single Domain Antibody (HPAB-AP504-YC)	FC	Camel VHH
HPAB-AP505-YC	Recombinant Camel Anti-MUC1 Single Domain Antibody (HPAB-AP505-YC)	ELISA	Camel VHH
HPAB-0736-YJ-VHH	Camelid Anti-MUC1 Recombinant Single Domain Antibody (HPAB-0736-YJ-VHH)	ELISA	Camelid VHH
HPAB-0737-YJ-VHH	Camelid Anti-MUC1 Recombinant Single Domain Antibody (HPAB-0737-YJ-VHH)	ELISA	Camelid VHH

CAT	Product Name	Application	Type
TAB-765	Mouse Anti-MUC1 Recombinant Antibody (clone Nacolomab); Fab Fragment	FC, IP, ELISA, Neut, FuncS, IF, ICC	Mouse Fab (IgG1, κ)
TAB-0388CL-F(E)	Mouse Anti-Human MUC1 Recombinant Antibody Fab Fragment	WB, IHC
TAB-411MZ-S(P)	Mouse Anti-MUC1 Recombinant Antibody; scFv Fragment (TAB-411MZ-S(P))	ELISA	Mouse scFv
TAB-416MZ-S(P)	Mouse Anti-MUC1 Recombinant Antibody; scFv Fragment (TAB-416MZ-S(P))	IF	Mouse scFv
TAB-417MZ-S(P)	Mouse Anti-MUC1 Recombinant Antibody; scFv Fragment (TAB-417MZ-S(P))	IF	Mouse scFv

CAT	Product Name	Application	Type
AGTO-L036E	anti-MUC1 immunotoxin C242 (Fab)-PE	Cytotoxicity assay, Functional assay
AGTO-L064E	anti-MUC1 immunotoxin H23 (scFv)-PE	Cytotoxicity assay, Functional assay

CAT	Product Name	Application	Type
PFBL-656	Mouse Anti-MUC1 Recombinant Antibody; Fab Fragment	WB, IF, FuncS	Mouse Fab
FAMAB-0225-YC-F(E)	Mouse Anti-MUC1 Recombinant Antibody (clone MUSE11); Fab Fragment	IHC	Mouse Fab
HPAB-0670-CN-F(E)	Human Anti-MUC1 Recombinant Antibody; Fab Fragment (HPAB-0670-CN-F(E))	FC	Human Fab
HPAB-0872LY-F(E)	Mouse Anti-MUC1 Recombinant Antibody; Fab Fragment (HPAB-0872LY-F(E))	ELISA, WB, FC	Mouse Fab
HPAB-0873LY-F(E)	Human Anti-MUC1 Recombinant Antibody; Fab Fragment (HPAB-0873LY-F(E))	ELISA, WB, FC	Humanized Fab

CAT	Product Name	Application	Type
TAB-412MZ	Human Anti-MUC1 Recombinant Antibody (TAB-412MZ)	ELISA	Chimeric (mouse/human) IgG
TAB-412MZ-S(P)	Mouse Anti-MUC1 Recombinant Antibody; scFv Fragment (TAB-412MZ-S(P))	ELISA	Mouse scFv
TAB-412MZ-F(E)	Human Anti-MUC1 Recombinant Antibody; Fab Fragment (TAB-412MZ-F(E))	ELISA	Chimeric (mouse/human) Fab

CAT	Product Name	Application	Type
TAB-413MZ	Human Anti-MUC1 Recombinant Antibody (TAB-413MZ)	ELISA	Humanized IgG
TAB-425MZ	Anti-Human MUC1 Recombinant Antibody (huDMB5F3)	ELISA, FC, FuncS, ICC	Humanized antibody
TAB-430MZ	Anti-Human MUC1 Recombinant Antibody (BLC595)	ELISA, FC	Humanized antibody
TAB-413MZ-F(E)	Human Anti-MUC1 Recombinant Antibody; Fab Fragment (TAB-413MZ-F(E))	ELISA	Humanized Fab
TAB-425MZ-F(E)	Anti-Human MUC1 Recombinant Antibody Fab Fragment (huDMB5F3)	FC	Humanized antibody

CAT	Product Name	Application	Type
TAB-431MZ	Anti-Human MUC1 Recombinant Antibody (PH1)	ELISA, WB, FC, IHC, SPR	Human antibody
TAB-432MZ	Human Anti-MUC1 Recombinant Antibody (TAB-432MZ)	ELISA, FC, FACS, DB, SPR	Human IgG
TAB-433MZ	Human Anti-MUC1 Recombinant Antibody (TAB-433MZ)	ELISA, FC, FACS, DB, SPR	Human IgG
TAB-434MZ	Human Anti-MUC1 Recombinant Antibody (TAB-434MZ)	ELISA, FC, FACS, DB, SPR	Human IgG
TAB-431MZ-F(E)	Anti-Human MUC1 Recombinant Antibody Fab Fragment (PH1)	ELISA, WB, FC, IHC	Human antibody

CAT	Product Name	Application	Type
Gly-012LC	Recombinant Anti-Human MUC1 Antibody (Fab glycosylation/Sialylated)	ELISA, FC, IHC	Humanized antibody
Gly-120LC	Recombinant Anti-Human MUC1 Antibody (Fab glycosylation)	ELISA	Mouse antibody

CAT	Product Name	Application	Type
Gly-012LC-1	Recombinant Anti-Human MUC1 Antibody (Fab glycosylation/Sialylated)	ELISA, FC, IHC	Humanized antibody

CAT	Product Name	Application	Type
Gly-109LC	Recombinant Anti-Human MUC1 Antibody (Fc glycosylation)	ELISA	Human antibody

CAT	Product Name	Application	Type
Gly-121LC	Recombinant Anti-Human MUC1 Antibody (Non-glycosylated)	ELISA	Mouse antibody
Gly-122LC	Recombinant Anti-Human MUC1 Antibody (Non-glycosylated)	ELISA	Mouse antibody
Gly-123LC	Recombinant Anti-Human MUC1 Antibody (Non-glycosylated)	ELISA	Mouse antibody
Gly-124LC	Recombinant Anti-Human MUC1 Antibody (Non-glycosylated)	ELISA	Mouse antibody

CAT	Product Name	Application	Type
BRD-0379MZ	Chicken Anti-MUC1 Polyclonal IgY	IHC, WB	Chicken antibody

CAT	Product Name	Application
MHC-LC054	PE-A*02:01/Human MUC1 (LLLTVLTVV) MHC Tetramer	FCM
MHC-LC781	A*0201/Human MUC-1 (LLLLTVLTV) MHC Tetramer	FCM
MHC-LC1950	PE-A2/Human MUC1 (NLTISDVSV) MHC Tetramer	FCM
MHC-YF272	A*02:01/Human MUC1 (LLLLTVLTV) MHC Monomer	MHC Multimer
MHC-YF570	A*02:01/Human Mucin (TLAPATEPA) MHC Pentamer	FCM

CAT	Product Name	Application	Type
MOR-2320	Hi-Affi™ Recombinant Rabbit Anti-MUC1 Monoclonal Antibody (DS2320AB)	IHC-P, IHC-Fr	IgG

CAT	Product Name	Application	Type
EPAF-0838LC	Recombinant Mouse Anti-Human MUC1 Antibody (SM3)	ELISA	IgG1
EPAF-0581CQ	Recombinant Mouse Anti-Human MUC1 Antibody (B27.29)	Neut, FC	IgG1
EPAF-0583CQ	Recombinant Mouse Anti-Human MUC1 Antibody (BC4E549)	Neut, FC	IgG1
EPAF-0584CQ	Recombinant Mouse Anti-Human MUC1 Antibody (DF3)	Neut, FC	IgG1

CAT	Product Name	Application	Type
PABC-399	Mouse Anti-MUC1 Recombinant Antibody (clone AR20.5)	ELISA, FC, FuncS	Mouse IgG1
PABC-400	Mouse Anti-MUC1 Recombinant Antibody (clone SM3)	FC, IHC-Fr, IF, ELISA, IHC-P	Mouse IgG1
FAMAB-1221CQ	Mouse Anti-MUC1 Recombinant Antibody (clone HMFG2)	FC, WB	Mouse IgG1
FAMAB-1222CQ	Human Anti-MUC1 Recombinant Antibody (clone E29)	WB, IHC	Human IgG1
VS3-XY1122	Mouse Anti-MUC1 Recombinant Antibody (clone CA009)	IHC, WB	Mouse IgG

CAT	Product Name	Application	Type
AFC-TAB-H56	Afuco™ Anti-MUC1 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-H56)	FuncS, IF, Neut, ELISA, FC	ADCC enhanced antibody
AFC-TAB-H65	Afuco™ Anti-MUC1 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-H65)	ELISA, FC, IP, FuncS, IF	ADCC enhanced antibody
AFC-TAB-026ML	Afuco™ Anti-MUC1 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-026ML)	ELISA, IHC, FC, IP, IF, FuncS	ADCC enhanced antibody
AFC-TAB-166	Afuco™ Anti-MUC1 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-166)	IP, IF, FuncS, FC, Neut, ELISA	ADCC enhanced antibody
AFC-TAB-H77	Afuco™ Human Anti-MUC1 Recombinant Antibody, ADCC Enhanced (AFC-TAB-H77)	ELISA, FC, IP, FuncS, IF	IgG1, κ

CAT	Product Name	Application	Type
HPAB-AP745-YC	Mouse Anti-MUC1 Recombinant Antibody (HPAB-AP745-YC)	ELISA	Mouse IgM

CAT	Product Name	Application	Type
HPAB-AP738-YC-S(P)	Mouse Anti-MUC1 Recombinant Antibody; scFv Fragment (HPAB-AP738-YC-S(P))	ELISA	Mouse scFv
HPAB-AP739-YC-S(P)	Mouse Anti-MUC1 Recombinant Antibody; scFv Fragment (HPAB-AP739-YC-S(P))	ELISA	Mouse scFv
HPAB-AP740-YC-S(P)	Mouse Anti-MUC1 Recombinant Antibody; scFv Fragment (HPAB-AP740-YC-S(P))	ELISA	Mouse scFv
HPAB-AP741-YC-S(P)	Mouse Anti-MUC1 Recombinant Antibody; scFv Fragment (HPAB-AP741-YC-S(P))	ELISA	Mouse scFv
HPAB-AP742-YC-S(P)	Mouse Anti-MUC1 Recombinant Antibody; scFv Fragment (HPAB-AP742-YC-S(P))	ELISA	Mouse scFv

CAT	Product Name	Application	Type
VS-0424-XY192	AbPlus™ Anti-MUC1 Magnetic Beads (139H2)	IP, Protein Purification
VS-0724-YC1494	AbPlus™ Anti-MUC1 Magnetic Beads (VS-0724-YC1494)	IP, Protein Purification

CAT	Product Name	Application	Type
VS-0125-FY26	Human Anti-MUC1 (clone 1B2) scFv-Fc Chimera	FC	Human IgG1, scFv-Fc

CAT	Product Name	Application	Type
VS-0225-XY169	CytoStream™ Mouse Anti-MUC1 Recombinant Antibody (VS-0225-XY169)	FC	Mouse IgG1, kappa

Customer Reviews and Q&As

Customer Review Q&As

Reliable in ELISA

We have been using Gatipotuzumab for ELISA, and it has provided consistent and reliable results. The optimal concentration was easy to determine, and the sensitivity is outstanding.

High specificity in FC

Flow cytometry with Gatipotuzumab has been very efficient. The antibody labeled MUC1-expressing cancer cells with high specificity, which facilitated our analysis significantly.

Minimal cross-reactivity

We noticed minimal cross-reactivity with non-human MUC1, which was expected but good to confirm. It's highly specific to human MUC1, as advertised.

Cite This Product

To accurately reference this product in your publication, please use the following citation information:

(Creative Biolabs Cat# TAB-026ML, RRID: AB_3111759)

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