Anti-CD33 (Gemtuzumab)-hydrazone-Calicheamicin ADC (CAT#: ADC-060LCT)

• Antibody Overview
• Humanized Murine CD33 Antibody (clone P67.6)

• Clone
• Gemtuzumab

• Antibody Isotype
• IgG4

• Linker
• hydrazone

• Linker Class/Description
• Acid-labile linkers, belonging to chemically cleavable linkers, are designed based on a pH-dependent release mechanism and remain intact during systemic circulation in the blood's neutral pH environment (pH 7.3-7.5) but to undergo hydrolysis and release drug once the ADC is internalized into mildly acidic endosomal (pH 5.0-6.5) and lysosomal (pH 4.5-5.0) compartments of the cell.

• Drug
• Calicheamicin

• Drug Class/Description
• Calicheamicin, produced by prokaryotic microorganisms, are a group of DNA cleaving agents with similar structure that binds in the minor grove of DNA in a relatively sequence-specific manner.

• Introduction
• CD33 or Siglec-3 is a transmembrane receptor expressed on cells of myeloid lineage. It is usually considered myeloid-specific, but it can also be found on some lymphoid cells. It binds sialic acids, therefore is a member of the SIGLEC family of lectins.

• Alternative Names
• CD33; CD33 molecule; p67; SIGLEC3; SIGLEC-3; myeloid cell surface antigen CD33; gp67; CD33 antigen (gp67); sialic acid binding Ig-like lectin 3; sialic acid-binding Ig-like lectin 3;

• Gene ID
• 945

• UniProt ID
• P20138

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