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    Anti-Human CD33 Recombinant Antibody (Gemtuzumab Ozogamicin) (CAT#: TAB-H37)

    Recombinant Humanized (from mouse) antibody to Human CD33. Gemtuzumab ozogamicin is a drug-linked monoclonal antibody (an antibody-drug conjugate) that was used to treat acute myelogenous leukemia. Gemtuzumab is a monoclonal antibody to CD33 linked to a cytotoxic agent from the class of calicheamicins.

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    • Modalities:

    Custom Production

    We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.

    Sequences:
    Isotype :
    Purity :
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    Other Requirements:
    We require custom production
    • Gene Expression
    • Datasheet
    • MSDS
    • COA
    Subcellular Location and Protein Expression
    Figure 1 IF staining of human cell line PC-3
    Figure 1 IF staining of human cell line PC-3
    (Immunofluorescent staining of human cell line PC-3 shows localization to nucleoplasm & plasma membrane.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/64807/1186_A4_3_selected.jpg
    Figure 2 IHC staining of human lymph node
    Figure 2 IHC staining of human lymph node
    (Immunohistochemical staining of human lymph node shows membranous and cytoplasmic positivity in germinal center cells and non-germinal center cells.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/35832/113039_A_9_8_selected.jpg
    Figure 3 IHC staining of human tonsil
    Figure 3 IHC staining of human tonsil
    (Immunohistochemical staining of human tonsil shows cytoplasmic positivity in germinal center cells and non-germinal center cells.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/11442/26430_A_6_8_selected.jpg
    Figure 4 IF staining of human cell line RH-30
    Figure 4 IF staining of human cell line RH-30
    (Immunofluorescent staining of human cell line RH-30 shows localization to nucleoplasm.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/64807/1413_G6_1_red_green.jpg
    Figure 5 IF staining of human cell line U-2 OS
    Figure 5 IF staining of human cell line U-2 OS
    (Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/64807/1200_A4_2_red_green.jpg
    Normal Tissue
    Figure 6 Kidney
    Figure 6 Kidney
    (Cells in tubules
    Staining:Medium
    Intensity: Strong
    Quantity: <25%
    Location: Cytoplasmic/membranous)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/79996/170702_A_9_5.jpg
    Figure 7 Lymph node
    Figure 7 Lymph node
    (Non-germinal center cells
    Staining:Medium
    Intensity: Strong
    Quantity: <25%
    Location: Cytoplasmic/membranous)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/79996/170702_A_9_8.jpg
    Figure 8 Spleen
    Figure 8 Spleen
    (Cells in red pulp
    Staining:Medium
    Intensity: Moderate
    Quantity:>75%
    Location: Cytoplasmic/membranous)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/79996/170702_B_8_4.jpg
    RNA Expression
    Figure 9 RNA cell line category: Cell line enhanced (HEL, HL-60, HMC-1, NB-4, RPMI-8226, THP-1, U-937)
    Figure 9 RNA cell line category: Cell line enhanced (HEL, HL-60, HMC-1, NB-4, RPMI-8226, THP-1, U-937)
    (Cell lines ordered by descending RNA expression order.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000105383-CD33

    Specifications

    • Host Species
    • Mouse
    • Derivation
    • Humanized (from mouse)
    • Type
    • IgG
    • Species Reactivity
    • Human
    • Applications
    • Suitable for use in ELISA, FC, IP, FuncS, IF, Neut, IHC and most other immunological methods.
    • CAS
    • 220578-59-6
    • Generic Name
    • gemtuzumab ozogamicin
    • ATC Code
    • L01XC05
    • DrugBank
    • DB00056
    • MW
    • 151–153 kDa

    Product Property

    • Purity
    • >95.0% as determined by analysis by SDS-PAGE.

    Target

    • Alternative Names
    • gemtuzumab ozogamicin;220578-59-6;CMA-676;P67.6;DB00056 CD33;CD33 molecule;CD33 antigen (gp67);myeloid cell surface antigen CD33;FLJ00391;p67;sialic acid binding Ig like lectin 3;SIGLEC 3;SIGLEC3;gp67;sialic acid binding Ig-like lectin 3;sialic acid-bindi

    Related Resources

    • Biosimilar Overview
    Please refer to Gemtuzumab Ozogamicin Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Gemtuzumab Ozogamicin.

    Product Notes

    This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

    • Increased sensitivity
    • Confirmed specificity
    • High repeatability
    • Excellent batch-to-batch consistency
    • Sustainable supply
    • Animal-free production

    See more details about Hi-Affi™ recombinant antibody benefits.

    Downloads

    Download resources about recombinant antibody development and antibody engineering to boost your research.

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