This CD25 specific binding protein (Z-domain of protein A) was investigated by an α-helix shuffling strategy. The primary scaffold protein was from a naive combinatorial library of the three-helix bundle Z domain derived from staphylococcal protein A. A hierarchical library was constructed through selective re-randomization of six amino acid positions in one of the two α-helices of the domain, making up the Taq DNA polymerase binding surface. After selections using monovalent phage display technology, second generation variants were identified having affinities (KD=10 pM) for CD25 as determined by biosensor technology. It's potential to be used in diagnostic, research and therapeutic applications.
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CAT | Product Name | Application | Type |
---|---|---|---|
IAB-B073(A) | Recombinant Anti-human IL2RA Intrabody [(D-Arg)9] | IF, ELISA, FuncS | scFv-(D-Arg)9 |
IAB-B073(G) | Recombinant Anti-human IL2RA Intrabody [+36 GFP] | IF, FC, WB, FuncS | scFv-(+36GFP) |
IAB-B073(T) | Recombinant Anti-human IL2RA Intrabody [Tat] | WB, CO-IP, FuncS | scFv-Tat |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-004 | Anti-Human CD25 Recombinant Antibody (Basiliximab) | IF, IP, Neut, FuncS, ELISA, FC, ICC | IgG1 - kappa |
PABX-030 | Recombinant Human Anti-CD25 Antibody (SDZCHII621) | Neut, FuncS | IgG |
PABX-030-F (E) | Recombinant Mouse Anti-CD25 Antibody Fab Fragment (SDZCHII621) | Neut, FuncS | Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-155 | Anti-Human CD25 Recombinant Antibody (Inolimomab) | IP, IF, FuncS, FC, Neut, ELISA, ICC | IgG1 - kappa |
TAB-641LC | Anti-human IL2RA Recombinant Antibody (Inolimomab) (TAB-641LC) | ELISA | |
TAB-641LC-S(P) | Anti-human IL2RA scFv Fragment (Inolimomab) | ELISA | |
TAB-641LC-F(E) | Anti-human IL2RA Fab Fragment (Inolimomab) | ELISA | |
PABX-029-S (P) | Recombinant Human Anti-CD25 Antibody scFv Fragment (Daclizumab) | WB, ELISA, FuncS | scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
AGTO-L027D | anti-IL2RA immunotoxin RFT5 (scFv)-DT | Cytotoxicity assay, Functional assay | |
AGTO-L027R | anti-IL2RA immunotoxin RFT5 (scFv)-RTA | Cytotoxicity assay, Functional assay | |
AGTO-L028E | anti-IL2RA immunotoxin RFT5 (IgG)-PE | Cytotoxicity assay, Functional assay | |
AGTO-L028D | anti-IL2RA immunotoxin RFT5 (IgG)-DT | Cytotoxicity assay, Functional assay | |
AGTO-L028R | anti-IL2RA immunotoxin RFT5 (IgG)-RTA | Cytotoxicity assay, Functional assay |
CAT | Product Name | Application | Type |
---|---|---|---|
PSBZ-082 | Mouse Anti-IL2RA Recombinant Antibody (clone SDZ CHI621); scFv Fragment | Block | Mouse scFv |
HPAB-0197-FY-S(P) | Mouse Anti-IL2RA Recombinant Antibody (clone WuTac); scFv Fragment | FC, DB, WB | Mouse scFv |
HPAB-M0454-YC-S(P) | Mouse Anti-IL2RA Recombinant Antibody; scFv Fragment (HPAB-M0454-YC-S(P)) | ELISA | Mouse scFv |
HPAB-2113-FY-S(P) | Mouse Anti-IL2RA Recombinant Antibody (clone MAK179); scFv Fragment | Inhib | Mouse scFv |
HPAB-1536WJ-S(P) | Rat Anti-IL2RA Recombinant Antibody; scFv Fragment (clone YTH 906.9.21) | ELISA, WB | Rat scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-646LC | Anti-human IL2RA Recombinant Antibody (48M54S) (TAB-646LC) | FuncS | Humanized antibody |
TAB-647LC | Anti-human IL2RA Recombinant Antibody (48M51L) (TAB-647LC) | FuncS | Humanized antibody |
TAB-648LC | Anti-human IL2RA Recombinant Antibody (48V54S) (TAB-648LC) | FuncS | Humanized antibody |
TAB-649LC | Anti-human IL2RA Recombinant Antibody (Dmab) (TAB-649LC) | FC | Humanized antibody |
TAB-650LC | Human Anti-IL2RA Recombinant Antibody (TAB-650LC) | Block | Humanized IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-642LC-F(E) | Human Anti-IL2RA Recombinant Antibody; Fab Fragment (TAB-642LC-F(E)) | ELISA, FC | Human Fab |
TAB-643LC-F(E) | Human Anti-IL2RA Recombinant Antibody; Fab Fragment (TAB-643LC-F(E)) | ELISA, FC | Human Fab |
TAB-644LC-F(E) | Human Anti-IL2RA Recombinant Antibody; Fab Fragment (TAB-644LC-F(E)) | ELISA, FC | Human Fab |
PABX-029 | Recombinant Human Anti-CD25 Antibody (Daclizumab) | WB, ELISA, FuncS, FC, Cyt | IgG |
PABX-029-F (E) | Recombinant Human Anti-CD25 Antibody Fab Fragment (Daclizumab) | WB, ELISA, FuncS | Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-1344CQ | Mouse Anti-IL2RA Recombinant Antibody (clone B-B10) | FC, Neut, WB, IF | Mouse IgG1, κ |
NEUT-1345CQ | Mouse Anti-IL2RA Recombinant Antibody (clone CBL017) | Neut, WB, IHC | Mouse IgG1 |
NEUT-1346CQ | Mouse Anti-IL2RA Recombinant Antibody (clone CBL242) | ELISA, FC, Neut | Mouse IgG1, κ |
NEUT-1348CQ | Mouse Anti-IL2RA Recombinant Antibody (clone CBL726) | WB, IHC, ICC, Neut | Mouse IgG1 |
NEUT-1349CQ | Mouse Anti-IL2RA Recombinant Antibody (clone 1X27) | IHC, Neut, WB | Mouse IgG1 |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-1350CQ | Mouse Anti-IL2RA Recombinant Antibody (clone 2R12) | Block, FC, ICC, IF, IHC, IP, WB | Mouse IgG1 |
NEUT-1356CQ | Rat Anti-Il2ra Recombinant Antibody (VMC199) | FC, IP, IHC, Block, Depletion | Rat IgG1, λ |
NEUT-1357CQ | Rat Anti-Il2ra Recombinant Antibody (clone 3C7) | FC, IP, Inhib | Rat IgG2b, κ |
NEUT-1358CQ | Rat Anti-Il2ra Recombinant Antibody (clone mAb0817) | Block, Depletion | Rat IgG1 |
NEUT-1359CQ | Rat Anti-Il2ra Recombinant Antibody (clone mAb0845) | Block, FC, IHC-Fr, IP | Rat IgG1 |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-1808 | Rabbit Anti-IL2RA Recombinant Antibody (clone DS1808AB) | IHC, ICC, IP | Rabbit IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
FAMAB-0197CQ | Mouse Anti-IL2RA Recombinant Antibody (clone 2C8) | ELISA, WB, FC | Mouse IgG1, κ |
FAMAB-0198CQ | Human Anti-IL2RA Recombinant Antibody (clone 4C1) | ELISA, WB, FC | Chimeric (mouse/human) IgG1, κ |
FAMAB-0199CQ | Mouse Anti-IL2RA Recombinant Antibody (clone 4F8) | ELISA, WB, FC | Mouse IgG2a, κ |
FAMAB-0200CQ | Human Anti-IL2RA Recombinant Antibody (clone huD1) | ELISA, FC, Block | Humanized IgG1, κ |
FAMAB-0201CQ | Mouse Anti-IL2RA Recombinant Antibody (clone D1) | ELISA, FC, Block | Mouse IgG2a, κ |
CAT | Product Name | Application | Type |
---|---|---|---|
FAMAB-0197CQ-F(E) | Mouse Anti-IL2RA Recombinant Antibody (clone 2C8); Fab Fragment | ELISA, WB, FC | Mouse Fab |
HPAB-0060-FY-F(E) | Human Anti-IL2RA Recombinant Antibody; Fab Fragment (HPAB-0060-FY-F(E)) | ELISA | Humanized Fab |
HPAB-0559-WJ-F(E) | Human Anti-IL2RA Recombinant Antibody; Fab Fragment (HPAB-0559-WJ-F(E)) | ELISA, FC | Human Fab |
HPAB-0560-WJ-F(E) | Human Anti-IL2RA Recombinant Antibody; Fab Fragment (HPAB-0560-WJ-F(E)) | ELISA, FC | Human Fab |
HPAB-0561-WJ-F(E) | Human Anti-IL2RA Recombinant Antibody; Fab Fragment (HPAB-0561-WJ-F(E)) | ELISA, FC | Human Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
AFC-TAB-004 | Afuco™ Anti-IL2RA ADCC Recombinant Antibody (Basiliximab), ADCC Enhanced | IF, IP, Neut, FuncS, ELISA, FC | ADCC enhanced antibody |
AFC-TAB-023 | Afuco™ Anti-IL2RA ADCC Recombinant Antibody (Daclizumab), ADCC Enhanced | ELISA, Neut, IF, IP, FC, FuncS | ADCC enhanced antibody |
AFC-TAB-155 | Afuco™ Anti-IL2RA ADCC Recombinant Antibody (Inolimomab), ADCC Enhanced | IP, IF, FuncS, FC, Neut, ELISA | ADCC enhanced antibody |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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