Anti-CD19 (clone W24HD37) Recombinant Antibody Coupled Liposome (VS-1024-FY46)
CAT#: VS-1024-FY46
The Anti-CD19 (clone W24HD37) Antibody Liposome is a novel targeted therapeutic formulation that utilizes advanced liposomal technology to precisely deliver anti-CD19 antibodies to tumor cells. By encapsulating the antibodies within liposomes, this innovative approach aims to significantly improve the therapeutic efficacy against B-cell malignancies while minimizing systemic toxicity and side effects commonly associated with traditional antibody therapies. As a result, this targeted delivery system promises to enhance patient outcomes in the treatment of conditions such as B-cell lymphomas and leukemias, offering a more effective and safer alternative for those affected by these diseases.





Specifications
- Potential Clinical Applications
- B-cell malignancies
- Immunoliposomes Method
- 1. Reduction of Antibody Fragments:
Reduce W24HD37-CCH using 5 mM DTT in HBS (pH 8.0) for 15-20 minutes at room temperature.
2. Removal of Unreacted Reducing Agent:
Remove unreacted DTT by chromatographic separation using a Sephadex G-25 column equilibrated with degassed HBS (pH 7.4).
3. Coupling to Liposome Mediators:
Combine W24HD37-CCH with Mal-PEG2000-DSPE particles at a molar ratio of 1:4 (antibody fragment: Mal-PEG2000-DSPE) and stir at room temperature for 16 hours.
4. Thiolating Antibodies:
Treat W24HD37 monoclonal antibody (mAb) with Traut's reagent at a molar ratio of 10:1 (Traut's reagent: W24HD37 mAb) for 1 hour using degassed HBS (pH 8.0).
5. Removal of Unreacted Traut's Reagent:
Remove unreacted Traut's reagent by chromatographic separation using a Sephadex G-50 column equilibrated with degassed HBS (pH 7.4).
6. Coupling to Liposome Mediators:
Combine thiolated W24HD37 mAb with a mixture of Mal-PEG2000-DSPE/mPEG2000-DSPE at a molar ratio of 1:10 (mAb: Mal-PEG2000-DSPE) and stir at room temperature for 16 hours.
7. Liposome Formation and Antibody Insertion:
Incubate the particles bound to Mal-PEG2000-DSPE (W24HD37-CCH, or W24HD37 mAb) with pre-formed liposomes (SIL) for 16 hours at room temperature with continuous stirring to facilitate the insertion of antibodies or fragments.
8. Separation:
Separate using a Sepharose CL-4B column under HBS (pH 7.4) conditions to remove unbound antibodies and free liposomes.
Product Composition
- Clone
- W24HD37
- Antibody Type
- IgG1
- Antibody Host
- Mouse
- Antibody Reactivity
- Human
- Antibody Description
- This is a mouse monoclonal IgG1, kappa antibody that specifically targets CD19 from human sources. It was developed through immunization with hairy cell leukaemia cells. The antibody is recommended for the detection of human CD19 using immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM) methodologies.
Product Property
- Storage
- See in the COA
- Storage Shelf Time
- See in the COA
Target Information
- Target
- CD19
- Introduction
- CD19 (CD19 Molecule) is a Protein Coding gene. Diseases associated with CD19 include Immunodeficiency, Common Variable, 3 and Common Variable Immunodeficiency. Among its related pathways are RET signaling and Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers. Gene Ontology (GO) annotations related to this gene include signal transducer activity, downstream of receptor.
- Alternative Names
- CD19 Molecule; B-Lymphocyte Surface Antigen B4; T-Cell Surface Antigen Leu-12; Differentiation Antigen CD19; CD19 Antigen; B-Lymphocyte Antigen CD19; CVID3; B4
- Full Name
- CD19 Molecule
- Gene ID
- 930
- UniProt ID
- P15391
- Cellular Localization
- Cell membrane
- Post Translation Modifications
- Phosphorylated on tyrosine following B-cell activation. Phosphorylated on tyrosine residues by LYN.
- Protein Refseq
- XP_011544283.1
- Function
- Functions as a coreceptor for the B-cell antigen receptor complex (BCR) on B-lymphocytes. Decreases the threshold for activation of downstream signaling pathways and for triggering B-cell responses to antigens. Activates signaling pathways that lead to the activation of phosphatidylinositol 3-kinase and the mobilization of intracellular Ca2+ stores.
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Datasheet
MSDS
COA
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