Afuco™ Anti-CD40 ADCC Recombinant Antibody (Dacetuzumab), ADCC Enhanced (CAT#: AFC-TAB-152)
This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant monoclonal antibody to CD40. Dacetuzumab (also known as SGN-40 or huS2C6) is a humanized monoclonal antibody being developed for the treatment of CD40-positive cancers like non-Hodgkin's lymphoma and hematological malignancies.
Specific Inquiry
Normal Tissue
RNA Expression
Figure 1 Lymph node
(Germinal center cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/72868/156401_A_8_8.jpg
(Germinal center cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/72868/156401_A_8_8.jpg
Figure 2 Tonsil
(Germinal center cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/31567/156626_A_6_8.jpg
(Germinal center cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/31567/156626_A_6_8.jpg
Figure 3 RNA cell line category: Cell line enhanced (CAPAN-2, Daudi, EFO-21)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000101017-CD40
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000101017-CD40
Figure 3 RNA cell line category: Cell line enhanced (CAPAN-2, Daudi, EFO-21)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000101017-CD40
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000101017-CD40
Specifications
- Immunogen
- Recombinant protein of extracellular domain of CD40
- Host Species
- Human
- Derivation
- Humanized (from mouse)
- Type
- ADCC enhanced antibody
- Species Reactivity
- Human
- Clone
- Dacetuzumab
- Applications
- IF, IP, Neut, FuncS, ELISA, FC
- Conjugate
- Unconjugated
- Generic Name
- Dacetuzumab
- Related Disease
- Multiple myeloma (MM)
Product Property
- Purity
- >95% by SDS-PAGE
- Storage
- Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- Dacetuzumab; 880486-59-9; SGN-40; huS2C6; anti-huCD40; SGN-14; PRO64553; SGN-40; huS2C6; CD40; CD40 molecule, TNF receptor superfamily member 5; TNFRSF5, tumor necrosis factor receptor superfamily, member 5; tumor necrosis factor receptor superfamily member 5; Bp50;
- Gene ID
- 958
- UniProt ID
- P25942
Related Resources
Please refer to Dacetuzumab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Dacetuzumab.
Asthma
Systemic Lupus Erythematosus
Primary Immunodeficiency
Allograft Rejection
Autoimmune Thyroid Disease
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "Dacetuzumab"
Anti-Human CD40 Recombinant Antibody (Dacetuzumab)Recombinant monoclonal antibody to CD40. Dacetuzumab (also known as SGN-40 or huS2C6) is a humanized monoclonal antibody being developed for the treatment of CD40-positive cancers like non-Hodgkin's lymphoma and hematological malignancies.
See other products for "CD40"
Select a product category from the dropdown menu below to view related products.
Please select product type
Humanized Antibody
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Human Antibody
Blocking Antibody
Neutralizing Antibody
Rabbit Monoclonal Antibody
Agonistic Antibody
Fab Fragment Antibody
Recombinant Antibody
Neuroscience Antibody
ADCC Enhanced Antibody
scFv Fragment Antibody
Single-domain Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-152 | Anti-Human CD40 Recombinant Antibody (Dacetuzumab) | IF, IP, Neut, FuncS, ELISA, FC, ICC | IgG1 |
| TAB-126CL | Human Anti-CD40 Recombinant Antibody (TAB-126CL) | Block, Cyt, FuncS, Inhib | Human IgG |
| TAB-189LC-F(E) | Anti-Human CD40 Recombinant Antibody Fab Fragment (F4) | SPR, ELISA | Humanized antibody |
| TAB-190LC-F(E) | Anti-Human CD40 Recombinant Antibody Fab Fragment (L3.17) | SPR, ELISA | Humanized antibody |
| TAB-194LC-F(E) | Human Anti-CD40 Recombinant Antibody; Fab Fragment (TAB-194LC-F(E)) | ELISA | Humanized Fab |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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