Human Anti-CD40 Recombinant Antibody (clone 3.1.1) (CAT#: HPAB-1833-FY)

This product is a recombinant antibody that recognizes CD40. The monoclonal antibody 3.1.1 reacts with the epitope of CD40. This anti-tumor activity for antibody 3.11 was enhanced when immune cells were present.

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Custom Production

We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.

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  • Published Data
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Activ

Figure 1 CH1-hinge basis of agonistically inactive IgG3 and superior IgG2.

Figure 1 CH1-hinge basis of agonistically inactive IgG3 and superior IgG2.

Representative FACS profile showing the percentage of OT-I cells (CD45.1+TCRVα2+) among CD8+ T cells in human CD40/FcγR-transgenic mice treated and analyzed together with control or anti-human CD40 antibodies of indicated clones (Clones 21.4.1 and 3.1.1 have been described in Patent No.:US 7,338,660; Clone 21.4.1 in the IgG2 form is also known as CP-870,893) and constant domains (30 μg per mouse).

Liu, X., Zhao, Y., Shi, H., Zhang, Y., Yin, X., Liu, M., ... & Li, F. (2019). Human immunoglobulin G hinge regulates agonistic anti-CD40 immunostimulatory and antitumour activities through biophysical flexibility. Nature communications, 10(1), 1-15.

Activ

Figure 2 CH1-hinge basis of agonistically inactive IgG3 and superior IgG2.

Figure 2 CH1-hinge basis of agonistically inactive IgG3 and superior IgG2.

Representative quantification showing the percentage of OT-I cells (CD45.1+TCRVα2+) among CD8+ T cells in human CD40/FcγR-transgenic mice treated and analyzed together with control or anti-human CD40 antibodies of indicated clones (Clones 3.1.1) and constant domains (30 μg per mouse).

Liu, X., Zhao, Y., Shi, H., Zhang, Y., Yin, X., Liu, M., ... & Li, F. (2019). Human immunoglobulin G hinge regulates agonistic anti-CD40 immunostimulatory and antitumour activities through biophysical flexibility. Nature communications, 10(1), 1-15.

Agonist

Figure 3 Shows inhibition in the growth of CD40 negative K562 tumors in SCID mice by different concentrations of anti-CD40 agonist mAb 3.1.1.

Figure 3 Shows inhibition in the growth of CD40 negative K562 tumors in SCID mice by different concentrations of anti-CD40 agonist mAb 3.1.1.

Agonist

Figure 4 Shows inhibition in the growth of BT 474 breast cancer cells in SCID-beige mice by anti-CD40 agonist antibodies.

Figure 4 Shows inhibition in the growth of BT 474 breast cancer cells in SCID-beige mice by anti-CD40 agonist antibodies.


Specifications

  • Host Species
  • Human
  • Type
  • Human IgG
  • Specificity
  • Human CD40
  • Species Reactivity
  • Human
  • Clone
  • 3.1.1
  • Applications
  • Activ, Agonist
  • Related Disease
  • Cancer

Product Property

  • Purity
  • >95% as determined by SDS-PAGE and HPLC analysis
  • Concentration
  • Please refer to the vial label for the specific concentration.
  • Buffer
  • PBS
  • Preservative
  • No preservatives
  • Storage
  • Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Applications

  • Application Notes
  • The CD40 antibody has been reported in applications of Activation, Agonist.

Target

  • Alternative Names
  • CD40 Molecule; CD40 Molecule, TNF Receptor Superfamily Member 5; CD40L Receptor; TNFRSF5; CDW40; Bp50; Tumor Necrosis Factor Receptor Superfamily, Member 5

Related Resources

  • Related Diseases

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

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TAB-262 Anti-Human CD40 Recombinant Antibody (TAB-262) IP, IF, FuncS, FC, Neut, ELISA, ICC IgG1
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TAB-202LC Anti-CD40 Recombinant Antibody (TAB-202LC) ELISA, FC, FuncS Chimeric (mouse/rhesus) IgG1
TAB-203LC Anti-CD40 Recombinant Antibody (TAB-203LC) ELISA, FC, FuncS Chimeric (mouse/rhesus) IgG4
TAB-188LC-F(E) Anti-Human CD40 Recombinant Antibody Fab Fragment (chi220) SPR, ELISA Chimeric antibody (mouse/human)

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