Human Anti-CD40 Recombinant Antibody (clone 3.1.1) (CAT#: HPAB-1833-FY)
This product is a recombinant antibody that recognizes CD40. The monoclonal antibody 3.1.1 reacts with the epitope of CD40. This anti-tumor activity for antibody 3.11 was enhanced when immune cells were present.
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Activ
Figure 1 CH1-hinge basis of agonistically inactive IgG3 and superior IgG2.
Representative FACS profile showing the percentage of OT-I cells (CD45.1+TCRVα2+) among CD8+ T cells in human CD40/FcγR-transgenic mice treated and analyzed together with control or anti-human CD40 antibodies of indicated clones (Clones 21.4.1 and 3.1.1 have been described in Patent No.:US 7,338,660; Clone 21.4.1 in the IgG2 form is also known as CP-870,893) and constant domains (30 μg per mouse).
Liu, X., Zhao, Y., Shi, H., Zhang, Y., Yin, X., Liu, M., ... & Li, F. (2019). Human immunoglobulin G hinge regulates agonistic anti-CD40 immunostimulatory and antitumour activities through biophysical flexibility. Nature communications, 10(1), 1-15.
Activ
Figure 2 CH1-hinge basis of agonistically inactive IgG3 and superior IgG2.
Representative quantification showing the percentage of OT-I cells (CD45.1+TCRVα2+) among CD8+ T cells in human CD40/FcγR-transgenic mice treated and analyzed together with control or anti-human CD40 antibodies of indicated clones (Clones 3.1.1) and constant domains (30 μg per mouse).
Liu, X., Zhao, Y., Shi, H., Zhang, Y., Yin, X., Liu, M., ... & Li, F. (2019). Human immunoglobulin G hinge regulates agonistic anti-CD40 immunostimulatory and antitumour activities through biophysical flexibility. Nature communications, 10(1), 1-15.
Agonist
Figure 3 Shows inhibition in the growth of CD40 negative K562 tumors in SCID mice by different concentrations of anti-CD40 agonist mAb 3.1.1.
Agonist
Figure 4 Shows inhibition in the growth of BT 474 breast cancer cells in SCID-beige mice by anti-CD40 agonist antibodies.
Specifications
- Host Species
- Human
- Type
- Human IgG
- Specificity
- Human CD40
- Species Reactivity
- Human
- Clone
- 3.1.1
- Applications
- Activ, Agonist
- Related Disease
- Cancer
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- The CD40 antibody has been reported in applications of Activation, Agonist.
Target
- Alternative Names
- CD40 Molecule; CD40 Molecule, TNF Receptor Superfamily Member 5; CD40L Receptor; TNFRSF5; CDW40; Bp50; Tumor Necrosis Factor Receptor Superfamily, Member 5
- Gene ID
- 958
- UniProt ID
- P25942
Related Resources
Asthma
Systemic Lupus Erythematosus
Primary Immunodeficiency
Allograft Rejection
Autoimmune Thyroid Disease
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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Extracellular Vesicle (EV) Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-262 | Anti-Human CD40 Recombinant Antibody (TAB-262) | IP, IF, FuncS, FC, Neut, ELISA, ICC | IgG1 |
| TAB-188LC | Anti-Human CD40 Recombinant Antibody (chi220) | SPR, ELISA, Inhib, FuncS | Chimeric antibody (mouse/human) |
| TAB-202LC | Anti-CD40 Recombinant Antibody (TAB-202LC) | ELISA, FC, FuncS | Chimeric (mouse/rhesus) IgG1 |
| TAB-203LC | Anti-CD40 Recombinant Antibody (TAB-203LC) | ELISA, FC, FuncS | Chimeric (mouse/rhesus) IgG4 |
| TAB-188LC-F(E) | Anti-Human CD40 Recombinant Antibody Fab Fragment (chi220) | SPR, ELISA | Chimeric antibody (mouse/human) |
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