Human Anti-EPCAM Recombinant Antibody (clone HuMAB UBS-54) (CAT#: HPAB-0163CQ)

This product is a recombinant human antibody that recognizes EPCAM. This product is a human monoclonal antibody that is capable of binding to human Ep-CAM.


Specific Inquiry
  • Size:
  • Conjugation:
  • Endotoxin:
  • Purity:
  • Fc Engineering:
  • Published Data
  • Tested Data
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
IHC

Figure 1 Localization of the fully human anti-EpCAM-directed UBS54 Ab applied i.p. in EpCAM-transgenic FVB/N-C57BL/6 hybrid mice.

Figure 1 Localization of the fully human anti-EpCAM-directed UBS54 Ab applied i.p. in EpCAM-transgenic FVB/N-C57BL/6 hybrid mice.

UBS54 localization was determined immunohistochemically 48 h after injection by staining with an anti-human IgG peroxidase conjugate. UBS54 localized on the EpCAM-expressing epithelial cell lining of the kidney (a), uterus (c), bladder (e), pancreas (f), colon (h), lung (j), liver (k), and salivary glands (o), whereas no UBS54 was observed in EpCAM-negative tissues, such as, for instance, heart (m). No specific staining was observed after incubation of similar EpCAM-expressing tissue sections obtained from transgenic mice injected with PBS: kidney (b), uterus (d), pancreas (g), colon (i), liver (l), and on slides of EpCAM-negative heart tissue (n).

Kosterink, J. G., McLaughlin, P. M., Lub-de Hooge, M. N., Hendrikse, H. H., van Zanten, J., van Garderen, E.,... & de Leij, L. F. (2007). Biodistribution studies of epithelial cell adhesion molecule (EpCAM)-directed monoclonal antibodies in the EpCAM-transgenic mouse tumor model. The Journal of Immunology, 179(2), 1362-1368.

FuncS

Figure 2 Biodistribution of ̶¹²⁵I-labeled mAbs in most relevant tissues and organs in EpCAM-transgenic FVB/N-V57BL/6 hybrid mice and in nontransgenic FVB/N-C57BL/6 hybrid mice 48 h after injection.

Figure 2 Biodistribution of ̶¹²⁵I-labeled mAbs in most relevant tissues and organs in EpCAM-transgenic FVB/N-V57BL/6 hybrid mice and in nontransgenic FVB/N-C57BL/6 hybrid mice 48 h after injection.

Biodistribution is expressed as tissue-to-blood ratio per gram tissue.

Kosterink, J. G., McLaughlin, P. M., Lub-de Hooge, M. N., Hendrikse, H. H., van Zanten, J., van Garderen, E.,... & de Leij, L. F. (2007). Biodistribution studies of epithelial cell adhesion molecule (EpCAM)-directed monoclonal antibodies in the EpCAM-transgenic mouse tumor model. The Journal of Immunology, 179(2), 1362-1368.


Specifications

  • Host Species
  • Human
  • Type
  • Human IgG1
  • Specificity
  • Human EPCAM
  • Species Reactivity
  • Human
  • Clone
  • HuMAB UBS-54
  • Applications
  • ELISA, FC, FuncS
  • Related Disease
  • Solid tumor

Product Property

  • Purity
  • >95% as determined by SDS-PAGE and HPLC analysis
  • Concentration
  • Please refer to the vial label for the specific concentration.
  • Buffer
  • PBS
  • Preservative
  • No preservatives
  • Storage
  • Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Applications

  • Application Notes
  • This antibody has been tested for use in Immunohistochemistry and Functional Assay. Please see the Published Data for further information.

Target

  • Alternative Names
  • Epithelial Cell Adhesion Molecule; Tumor-Associated Calcium Signal Transducer 1; Major Gastrointestinal Tumor-Associated Protein GA733-2; Adenocarcinoma-Associated Antigen; Cell Surface Glycoprotein Trop-1; Epithelial Glycoprotein 314; TACSTD1; EGP314; MIC18; TROP1; M4S1; KSA; Membrane Component, Chromosome 4, Surface Marker (35kD Glycoprotein); Antigen Identified By Monoclonal Antibody AUA1; Human Epithelial Glycoprotein-2; Epithelial Cell Surface Antigen;

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "Clone HuMAB UBS-54"

See other products for "EPCAM"

Immunotoxin

CAT Product Name Application Type
AGTO-L013E anti-EPCAM immunotoxin MOC31 (IgG)-PE Cytotoxicity assay, Functional assay
AGTO-L013D anti-EPCAM immunotoxin MOC31 (IgG)-DT Cytotoxicity assay, Functional assay
AGTO-L013G anti-EPCAM immunotoxin MOC31 (IgG)-Gel Cytotoxicity assay, Functional assay
AGTO-L013R anti-EPCAM immunotoxin MOC31 (IgG)-RTA Cytotoxicity assay, Functional assay
AGTO-L013O anti-EPCAM immunotoxin MOC31 (IgG)-Bouganin Cytotoxicity assay, Functional assay

Humanized Antibody

Recombinant Antibody

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-1163 Hi-Affi™ Rabbit Anti-EPCAM Recombinant Antibody (clone DS1163AB) IHC-P, WB, ICC, ICC, IF Rabbit IgG

ADCC Enhanced Antibody

CAT Product Name Application Type
AFC-TAB-106 Afuco™ Anti-EPCAM ADCC Recombinant Antibody (Adecatumumab), ADCC Enhanced ELISA, IP, FC, FuncS, Neut ADCC enhanced antibody
AFC-TAB-213 Afuco™ Anti-EPCAM ADCC Recombinant Antibody (Tucotuzumab), ADCC Enhanced Neut, ELISA, IF, IP, FuncS ADCC enhanced antibody
AFC-TAB-701 Afuco™ Anti-EpCAM ADCC Recombinant Antibody (Edrecolomab), ADCC Enhanced ELISA, IP, FC, FuncS, IF, Neut ADCC enhanced antibody

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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