Anti-IGF1R (clone 13F5) Recombinant Antibody Coupled Liposome (VS-1024-FY251) (CAT#: VS-1024-FY251)

• Potential Clinical Applications
• Adrenocortical carcinoma

• Clone
• 13F5

• Antibody Type
• IgG1, kappa

• Antibody Host
• Mouse

• Antibody Reactivity
• Human

• Antibody Description
• This is a mouse monoclonal IgG1, kappa antibody, specifically designed against the IGF-I receptor, which has been purified from human placental tissues. The Anti-IGF-1 Receptor α/IGF1R Antibody (13F5) is highly recommended for the detection of IGF-IRα in human samples. It is suitable for various applications, including immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry (IHC-P), and flow cytometry (FCM).

• Storage
• See in the COA

• Storage Shelf Time
• See in the COA

• Target
• IGF1R

• Introduction
• This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

• Alternative Names
• Insulin Like Growth Factor 1 Receptor

• Full Name
• Insulin Like Growth Factor 1 Receptor

• Gene ID
• 3480

• UniProt ID
• P08069

• Sequence Similarities
• Belongs to the protein kinase superfamily.

• Cellular Localization
• Cell membrane

• Post Translation Modifications
• Autophosphorylated on tyrosine residues in response to ligand binding.
  Autophosphorylation occurs in trans, i.e.
  one subunit of the dimeric receptor phosphorylates tyrosine residues on the other subunit.
  Autophosphorylation occurs in a sequential manner; Tyr-1165 is predominantly phosphorylated first, followed by phosphorylation of Tyr-1161 and Tyr-1166.

• Protein Refseq
• XP_011519818.1; XP_011519819.1; XP_016877626.1; XP_047288398.1; XP_047288399.1

• Function
• Receptor tyrosine kinase which mediates actions of insulin-like growth factor 1 (IGF1).
  Binds IGF1 with high affinity and IGF2 and insulin (INS) with a lower affinity.
  The activated IGF1R is involved in cell growth and survival control.
  IGF1R is crucial for tumor transformation and survival of malignant cell.

Select a product category from the dropdown menu below to view related products.