Anti-IGF1R (clone 13F5) Recombinant Antibody Coupled Liposome (VS-1024-FY251)

Name: Anti-IGF1R (clone 13F5) Recombinant Antibody Coupled Liposome (VS-1024-FY251)
SKU: VS-1024-FY251
Rating: 5 (1 reviews)

CAT#: VS-1024-FY251

IGF1-R (Insulin-like Growth Factor 1 Receptor) antibody liposomes are a targeted therapeutic system that can bind to IGF1-R and subsequently block its signaling pathway. This treatment strategy has the potential to enhance anti-cancer effects by inhibiting the growth and survival of tumor cells. Additionally, combining it with other targets such as EGFR (Epidermal Growth Factor Receptor) may achieve a stronger inhibitory effect.

Gene Expression

Normal Tissue Figure 1 Cerebral cortex

Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Glial cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Neuronal cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Neuropil
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10268/32662_B_7_5.jpg

Normal Tissue Figure 2 Colon

Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Glandular cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10268/32662_A_7_3.jpg

Normal Tissue Figure 3 Liver

Cholangiocytes
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Hepatocytes
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10268/32662_A_8_4.jpg

Normal Tissue Figure 4 Kidney

Cells in glomeruli
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Cells in tubules
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10268/32662_A_7_5.jpg

Normal Tissue Figure 5 Testis

Cells in seminiferous ducts
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Leydig cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10268/32662_A_6_6.jpg

Normal Tissue Figure 6 Heart muscle

Cardiomyocytes
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10268/32662_B_5_6.jpg

Normal Tissue Figure 7 Lymph node

Germinal center cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10268/32662_A_7_8.jpg

RNA Expression Figure 8 RNA cell line category: Low cell line specificity

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000140443-IGF1R

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Sub Cat	Product Name	Liposome Name	Datasheet
VS-1124-FY4251	Anti-IGF1R (clone 13F5) Recombinant Antibody Coupled PEGylated Liposome (VS-1124-FY4251)	PEGylated liposome
VS-1124-FY4252	Anti-IGF1R (clone 13F5) Recombinant Antibody Coupled Triptolide-loaded Liposome (VS-1124-FY4252)	Triptolide-loaded liposome
VS-1124-FY4253	Anti-IGF1R (clone 13F5) Recombinant Antibody Coupled Gd-SLs Liposome (VS-1124-FY4253)	Gd-SLs liposome
VS-1124-FY4254	Anti-IGF1R (clone 13F5) Recombinant Antibody Coupled Phospholipid Liposome (VS-1124-FY4254)	Phospholipid liposome
VS-1124-FY4255	Anti-IGF1R (clone 13F5) Recombinant Antibody Coupled Cationic Liposome (VS-1124-FY4255)	Cationic liposome
VS-1124-FY4256	Anti-IGF1R (clone 13F5) Recombinant Antibody Coupled Adriamycin-encapsulated Liposome (VS-1124-FY4256)	Adriamycin-encapsulated liposome
VS-1124-FY4257	Anti-IGF1R (clone 13F5) Recombinant Antibody Coupled Magnetofluorescent Liposome (VS-1124-FY4257)	Magnetofluorescent liposome
VS-1124-FY4258	Anti-IGF1R (clone 13F5) Recombinant Antibody Coupled pH-sensitive Liposome (VS-1124-FY4258)	pH-sensitive liposome
VS-1124-FY4259	Anti-IGF1R (clone 13F5) Recombinant Antibody Coupled Phototoxic Liposome (VS-1124-FY4259)	Phototoxic liposome
VS-1124-FY4260	Anti-IGF1R (clone 13F5) Recombinant Antibody Coupled Targeted Liposome (VS-1124-FY4260)	Targeted Liposome
VS-1124-FY4261	Anti-IGF1R (clone 13F5) Recombinant Antibody Coupled Apt1-Liposome (VS-1124-FY4261)	Apt1-liposome
VS-1124-FY4262	Anti-IGF1R (clone 13F5) Recombinant Antibody Coupled Thermosensitive Liposome (VS-1124-FY4262)	Thermosensitive liposome
VS-1124-FY4263	Anti-IGF1R (clone 13F5) Recombinant Antibody Coupled Clodronate Liposome (VS-1124-FY4263)	Clodronate liposome
VS-1124-FY4264	Anti-IGF1R (clone 13F5) Recombinant Antibody Coupled Galcer Liposome (VS-1124-FY4264)	Galcer liposome
VS-1124-FY4265	Anti-IGF1R (clone 13F5) Recombinant Antibody Coupled HBsAg-loaded Liposome (VS-1124-FY4265)	HBsAg-loaded liposome
VS-1124-FY4266	Anti-IGF1R (clone 13F5) Recombinant Antibody Coupled Phospholipid Liposome and Cationic Liposome (VS-1124-FY4266)	Phospholipid liposome and Cationic liposome
VS-1124-FY4267	Anti-IGF1R (clone 13F5) Recombinant Antibody Coupled ISMN Liposome (VS-1124-FY4267)	ISMN liposome

More Infomation

Specifications

Potential Clinical Applications
Adrenocortical carcinoma

Product Composition

Clone
13F5

Antibody Type
IgG1, kappa

Antibody Host
Mouse

Antibody Reactivity
Human

Antibody Description
This is a mouse monoclonal IgG1, kappa antibody, specifically designed against the IGF-I receptor, which has been purified from human placental tissues. The Anti-IGF-1 Receptor α/IGF1R Antibody (13F5) is highly recommended for the detection of IGF-IRα in human samples. It is suitable for various applications, including immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry (IHC-P), and flow cytometry (FCM).

Product Property

Storage
See in the COA

Storage Shelf Time
See in the COA

Target Information

Target
IGF1R

Introduction
This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

Alternative Names
Insulin Like Growth Factor 1 Receptor

Full Name
Insulin Like Growth Factor 1 Receptor

Gene ID
3480

UniProt ID
P08069

Sequence Similarities
Belongs to the protein kinase superfamily.

Cellular Localization
Cell membrane

Post Translation Modifications
Autophosphorylated on tyrosine residues in response to ligand binding.
Autophosphorylation occurs in trans, i.e.
one subunit of the dimeric receptor phosphorylates tyrosine residues on the other subunit.
Autophosphorylation occurs in a sequential manner; Tyr-1165 is predominantly phosphorylated first, followed by phosphorylation of Tyr-1161 and Tyr-1166.

Protein Refseq
XP_011519818.1; XP_011519819.1; XP_016877626.1; XP_047288398.1; XP_047288399.1

Function
Receptor tyrosine kinase which mediates actions of insulin-like growth factor 1 (IGF1).
Binds IGF1 with high affinity and IGF2 and insulin (INS) with a lower affinity.
The activated IGF1R is involved in cell growth and survival control.
IGF1R is crucial for tumor transformation and survival of malignant cell.

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Related Signaling Pathways

Insulin Signaling Pathway

Related Diseases

Endocrine Resistance

Type I Diabetes Mellitus

Downloadable Resources

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Datasheet

Datasheet - VS-1024-FY251.pdf

MSDS

MSDS - VS-1024-FY251.pdf

COA

Certificate of Analysis Lookup

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MOR-1755	Rabbit Anti-IGF1R Recombinant Antibody (clone DS1755AB)	IP, ELISA	Rabbit IgG
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HPAB-0084-YC	Human Anti-IGF1R Recombinant Antibody (HPAB-0084-YC)	ELISA, FC	Humanized IgG
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HPAB-0210CQ	Human Anti-IGF1R Recombinant Antibody (clone 15H12)	ELISA, FC, Neut	Human IgG3, κ
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NS-041CN	Mouse Anti-IGF1R Recombinant Antibody (NS-041CN)	ELISA, WB, FC	Mouse IgG
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NS-041CN-S(P)	Mouse Anti-IGF1R Recombinant Antibody; scFv Fragment (NS-041CN-S(P))	ELISA, WB, FC	Mouse scFv

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