Anti-IL2RA (clone MAK179) Recombinant Antibody Coupled Liposome (VS-1024-FY86)
CAT#: VS-1024-FY86
Lipidosomes conjugated with anti-CD25 antibodies show promising prospects in the treatment of gliomas. CD25 is a marker on the surface of leukocytes that is often associated with immune suppression in the tumor microenvironment. By combining anti-CD25 antibodies with lipidosomes, it is possible to specifically target tumor-associated immune cells, thereby increasing the local concentration of the drug. This technology not only enhances the drug's effectiveness against tumor cells but also helps to improve the safety and tolerability of the treatment. Future research may further optimize its application in gliomas, providing new therapeutic strategies.
Gene Expression
Normal Tissue
Figure 1 Lymph node
Germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/54622/137874_A_8_8.jpg
Normal Tissue
Figure 2 Tonsil
Non-germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/54622/137874_A_4_8.jpg
RNA Expression
Figure 3 RNA cell line category: Cell line enriched (HDLM-2)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000134460-IL2RA
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More Infomation
Specifications
- Potential Clinical Applications
- Glioma
Product Composition
- Clone
- MAK179
- Antibody Type
- IgG1, kappa
- Antibody Host
- Human
- Antibody Reactivity
- Human
- Antibody Description
- The recombinant human antibody exhibits a high degree of specificity in its binding affinity toward human CD25, a cell surface protein that plays a crucial role in the immune response. This engineered antibody has been meticulously designed to recognize and attach to CD25 with remarkable precision, ensuring that it can effectively target cells expressing this marker. This characteristic makes it a valuable tool for various therapeutic and diagnostic applications, particularly in the context of immunological disorders and cancer therapies.
Product Property
- Storage
- See in the COA
- Storage Shelf Time
- See in the COA
Target Information
- Target
- IL2RA
- Introduction
- The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency.
- Alternative Names
- Interleukin 2 Receptor Subunit Alpha
- Full Name
- Interleukin 2 Receptor Subunit Alpha
- Gene ID
- 3559
- UniProt ID
- P01589
- Cellular Localization
- Membrane
- Post Translation Modifications
- Glycosylation at Asn70, Asn89, Thr218, Thr224, Thr229, and Thr237 (NX_P01589 [NX_P01589-1])
Modification sites at PhosphoSitePlus (P01589)
Glycosylation from GlyGen (P01589) 6 sites
- Protein Refseq
- NP_001295171.1; NP_000408.1
- Function
- Receptor for interleukin-2.
The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity.
TREGs suppress the activation and expansion of autoreactive T-cells.
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Datasheet
MSDS
COA
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| IAB-B073(A) | Recombinant Anti-human IL2RA Intrabody [(D-Arg)9] | IF, ELISA, FuncS | scFv-(D-Arg)9 |
| IAB-B073(G) | Recombinant Anti-human IL2RA Intrabody [+36 GFP] | IF, FC, WB, FuncS | scFv-(+36GFP) |
| IAB-B073(T) | Recombinant Anti-human IL2RA Intrabody [Tat] | WB, CO-IP, FuncS | scFv-Tat |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-004 | Anti-Human CD25 Recombinant Antibody (Basiliximab) | IF, IP, Neut, FuncS, ELISA, FC, ICC | IgG1 - kappa |
| PABX-030 | Recombinant Human Anti-CD25 Antibody (SDZCHII621) | Neut, FuncS | IgG |
| PABX-030-F (E) | Recombinant Mouse Anti-CD25 Antibody Fab Fragment (SDZCHII621) | Neut, FuncS | Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-155 | Anti-Human CD25 Recombinant Antibody (TAB-155) | IP, IF, FuncS, FC, Neut, ELISA, ICC | IgG1 - kappa |
| TAB-641LC | Anti-human IL2RA Recombinant Antibody (TAB-641LC) | ELISA | |
| TAB-641LC-S(P) | Anti-human IL2RA scFv Fragment (TAB-641LC-S(P)) | ELISA | |
| TAB-641LC-F(E) | Anti-human IL2RA Fab Fragment (TAB-641LC-F(E)) | ELISA | |
| PABX-029-S (P) | Recombinant Human Anti-CD25 Antibody scFv Fragment (Daclizumab) | WB, ELISA, FuncS | scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AGTO-L027D | anti-IL2RA immunotoxin RFT5 (scFv)-DT | Cytotoxicity assay, Functional assay | |
| AGTO-L027R | anti-IL2RA immunotoxin RFT5 (scFv)-RTA | Cytotoxicity assay, Functional assay | |
| AGTO-L078E | IL2-PE immunotoxin | Cytotoxicity assay, Functional assay | |
| AGTO-L078D | IL2-DT immunotoxin | Cytotoxicity assay, Functional assay | |
| AGTO-L078R | IL2-RTA immunotoxin | Cytotoxicity assay, Functional assay |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBL-242 | Human Anti-IL2RA Recombinant Antibody (clone 1H4); scFv Fragment | WB, IHC, FuncS | Human scFv |
| PSBZ-020 | Mouse Anti-IL2RA Recombinant Antibody (clone CHI621); scFv Fragment | Block | Mouse scFv |
| FAMAB-0197CQ-S(P) | Mouse Anti-IL2RA Recombinant Antibody (clone 2C8); scFv Fragment | ELISA, WB, FC | Mouse scFv |
| FAMAB-0198CQ-S(P) | Mouse Anti-IL2RA Recombinant Antibody (clone 4C1); scFv Fragment | ELISA, WB, FC | Mouse scFv |
| HPAB-1536WJ-S(P) | Rat Anti-IL2RA Recombinant Antibody; scFv Fragment (clone YTH 906.9.21) | ELISA, WB | Rat scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABZ-082 | Human Anti-IL2RA Recombinant Antibody (clone SDZ CHI621) | Block | Chimeric (mouse/human) IgG |
| HPAB-0060-FY | Human Anti-IL2RA Recombinant Antibody (HPAB-0060-FY) | ELISA, PD | Humanized IgG1, κ |
| HPAB-0197-FY | Mouse Anti-IL2RA Recombinant Antibody (clone WuTac) | FC, DB, WB | Mouse IgG |
| ZG-0845F | Mouse Anti-IL2RA Recombinant Antibody (clone ITYV) | FC | Mouse IgG1 |
| VS3-WK802 | Mouse Anti-IL2RA Recombinant Antibody (clone W4A7G7B6) | FC, IF | Mouse IgG2a |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBL-608 | Human Anti-IL2RA Recombinant Antibody (clone RTF5); Fab Fragment | WB, FuncS | Chimeric (mouse/human) Fab |
| HPAB-0559-WJ-F(E) | Human Anti-IL2RA Recombinant Antibody; Fab Fragment (HPAB-0559-WJ-F(E)) | ELISA, FC | Human Fab |
| HPAB-0560-WJ-F(E) | Human Anti-IL2RA Recombinant Antibody; Fab Fragment (HPAB-0560-WJ-F(E)) | ELISA, FC | Human Fab |
| HPAB-0561-WJ-F(E) | Human Anti-IL2RA Recombinant Antibody; Fab Fragment (HPAB-0561-WJ-F(E)) | ELISA, FC | Human Fab |
| HPAB-1536WJ-F(E) | Rat Anti-IL2RA Recombinant Antibody; Fab Fragment (clone YTH 906.9.21) | ELISA, WB | Rat Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-642LC | Human Anti-IL2RA Recombinant Antibody (TAB-642LC) | ELISA, FC, Inhib | Human IgG1, κ |
| TAB-642LC-S(P) | Human Anti-IL2RA Recombinant Antibody; scFv Fragment (TAB-642LC-S(P)) | ELISA, FC | Human scFv |
| TAB-643LC-S(P) | Human Anti-IL2RA Recombinant Antibody; scFv Fragment (TAB-643LC-S(P)) | ELISA, FC | Human scFv |
| TAB-644LC-S(P) | Human Anti-IL2RA Recombinant Antibody; scFv Fragment (TAB-644LC-S(P)) | ELISA, FC | Human scFv |
| TAB-645LC-S(P) | Human Anti-IL2RA Recombinant Antibody; scFv Fragment (TAB-645LC-S(P)) | ELISA, FC | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-646LC-S(P) | Anti-human IL2RA scFv Fragment (48M54S) | ELISA, FC | Humanized antibody |
| TAB-647LC-S(P) | Anti-human IL2RA scFv Fragment (48M51L) | ELISA, FC | Humanized antibody |
| TAB-648LC-S(P) | Anti-human IL2RA scFv Fragment (48V54S) | ELISA, FC | Humanized antibody |
| TAB-649LC-S(P) | Anti-human IL2RA scFv Fragment (Dmab) | FC | Humanized antibody |
| TAB-650LC-S(P) | Human Anti-IL2RA Recombinant Antibody; scFv Fragment (TAB-650LC-S(P)) | ELISA | Humanized scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1344CQ | Mouse Anti-IL2RA Recombinant Antibody (clone B-B10) | FC, Neut, WB, IF | Mouse IgG1, κ |
| NEUT-1345CQ | Mouse Anti-IL2RA Recombinant Antibody (clone CBL017) | Neut, WB, IHC | Mouse IgG1 |
| NEUT-1346CQ | Mouse Anti-IL2RA Recombinant Antibody (clone CBL242) | ELISA, FC, Neut | Mouse IgG1, κ |
| NEUT-1348CQ | Mouse Anti-IL2RA Recombinant Antibody (clone CBL726) | WB, IHC, ICC, Neut | Mouse IgG1 |
| NEUT-1349CQ | Mouse Anti-IL2RA Recombinant Antibody (NEUT-1349CQ) | IHC, Neut, WB | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1350CQ | Mouse Anti-IL2RA Recombinant Antibody (NEUT-1350CQ) | Block, FC, ICC, IF, IHC, IP, WB | Mouse IgG1 |
| NEUT-1356CQ | Rat Anti-Il2ra Recombinant Antibody (VMC199) | FC, IP, IHC, Block, Depletion | Rat IgG1, λ |
| NEUT-1357CQ | Rat Anti-Il2ra Recombinant Antibody (clone 3C7) | FC, IP, Inhib | Rat IgG2b, κ |
| NEUT-1358CQ | Rat Anti-Il2ra Recombinant Antibody (NEUT-1358CQ) | Block, Depletion | Rat IgG1 |
| NEUT-1359CQ | Rat Anti-Il2ra Recombinant Antibody (NEUT-1359CQ) | Block, FC, IHC-Fr, IP | Rat IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1808 | Rabbit Anti-IL2RA Recombinant Antibody (clone DS1808AB) | IHC, ICC, IP | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-004 | Afuco™ Anti-IL2RA ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-004) | IF, IP, Neut, FuncS, ELISA, FC | ADCC enhanced antibody |
| AFC-TAB-023 | Afuco™ Anti-IL2RA ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-023) | ELISA, Neut, IF, IP, FC, FuncS | ADCC enhanced antibody |
| AFC-TAB-155 | Afuco™ Anti-IL2RA ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-155) | IP, IF, FuncS, FC, Neut, ELISA | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0424-XY150 | AbPlus™ Anti-IL2RA Magnetic Beads (2R12) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0924-YC133 | Human Anti-IL2RA Recombinant Antibody Hexamer (VS-0924-YC133), CDC Enhanced | CDC | Antibody hexamer |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0924-YC47 | Rabbit Anti-IL2RA Antibody (VS-0924-YC47) - Cancer Stem Cell Marker | IHC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0125-FY44 | Human Anti-IL2RA (clone MAK179) scFv-Fc Chimera | Inhib | Human IgG1, scFv-Fc |
| VS-0425-FY42 | Mouse Anti-IL2RA (clone mAb1) scFv-Fc Chimera | ELISA | Mouse IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0225-XY135 | CytoStream™ Mouse Anti-IL2RA Recombinant Antibody (clone BC96) | FC | Mouse IgG1, kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC386 | Recombinant Anti-IL2RA Vesicular Antibody, EV Displayed (VS-0425-YC386) | ELISA, FC, Neut, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY3520 | Anti-IL2RA Immunohistochemistry Kit | IHC | |
| VS-0525-XY3521 | Anti-Mouse IL2RA Immunohistochemistry Kit | IHC | |
| VS-0525-XY3522 | Anti-Rat IL2RA Immunohistochemistry Kit | IHC |
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