Anti-PD-L1 Antibody-Cytokine Fusion Protein, IgG (1.14.4)-TNFSF8
CAT#: ACFP-CQ5215
This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-PD-L1 IgG to TNFSF8. It was expressed in CHO and purified with affinity chromatography. The immunocytokine retains the ability to bind the PD-L1 as well as the biological activity of TNFSF8.






Specifications
- Target
- PD-L1
- Molecule Class
- IgG-TNFSF8
- Species Reactivity
- Human
- Expression Host
- CHO
- Clone
- 1.14.4
- Cytokine 1
- TNFSF8
- Cytokines 1 Description
- The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF8/CD30, which is a cell surface antigen and a marker for Hodgkin lymphoma and related hematologic malignancies. The engagement of this cytokine expressed on B cell surface plays an inhibitory role in modulating Ig class switch. This cytokine was shown to enhance cell proliferation of some lymphoma cell lines, while to induce cell death and reduce cell proliferation of other lymphoma cell lines. The pleiotropic biologic activities of this cytokine on different CD30+ lymphoma cell lines may play a pathophysiologic role in Hodgkin's and some non-Hodgkin's lymphomas. Two transcript variants encoding different isoforms have been found for this gene.
- Cytokine 1 Species
- Human
- Applications
- This product can be used therapeutically to deliver biologically active ligands to a desired tissue.
Target
- Introduction
- This gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation.
- Alternative Names
- CD274; PD-L1; PDCD1L1; B7-H; Programmed Death Ligand 1; Programmed Cell Death 1 Ligand 1; PDCD1LG1; B7H1
- Gene ID
- 29126
- UniProt ID
- Q9NZQ7
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Datasheet
MSDS
COA
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See other products for "Clone 1.14.4"
- CAT
- Product Name
See other products for "Cd274"
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CAT | Product Name | Application | Type |
---|---|---|---|
PFBL-298 | Human Anti-CD274 Recombinant Antibody (clone CBLC-006); Fab Fragment | WB, ELISA, FuncS | Human Fab |
HPAB-0193-YC-F(E) | Human Anti-CD274 Recombinant Antibody; Fab Fragment (HPAB-0193-YC-F(E)) | ELISA | Humanized Fab |
HPAB-0194-YC-F(E) | Mouse Anti-CD274 Recombinant Antibody; Fab Fragment (HPAB-0194-YC-F(E)) | ELISA | Mouse Fab |
HPAB-0195-YC-F(E) | Human Anti-CD274 Recombinant Antibody; Fab Fragment (HPAB-0195-YC-F(E)) | SPR | Humanized Fab |
HPAB-0196-YC-F(E) | Human Anti-CD274 Recombinant Antibody; Fab Fragment (HPAB-0196-YC-F(E)) | FC | Human Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-0995CL | Human Anti-CD274 Recombinant Antibody (TAB-0995CL) | ELISA, FC | Chimeric (Mouse/Human) IgG1, κ |
TAB-0995CL-S(P) | Human Anti-CD274 Recombinant Antibody; scFv Fragment (TAB-0995CL-S(P)) | ELISA, FC | Human scFv |
TAB-0995CL-F(E) | Human Anti-CD274 Recombinant Antibody; Fab Fragment (TAB-0995CL-F(E)) | ELISA, FC | Chimeric (Mouse/Human) Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-0992CL-S(P) | Mouse Anti-CD274 Recombinant Antibody; scFv Fragment (TAB-0992CL-S(P)) | FC | Mouse scFv |
TAB-0262CL-F(E) | Mouse Anti-CD274 Recombinant Antibody; Fab Fragment (TAB-0262CL-F(E)) | ELISA, WB, SPR, FuncS | Mouse Fab |
TAB-1009CL-F(E) | Mouse Anti-CD274 Recombinant Antibody; Fab Fragment (TAB-1009CL-F(E)) | WB, IHC | Mouse Fab |
TAB-1010CL-F(E) | Anti-Human CD274 Recombinant Antibody Fab Fragment | FC | |
TAB-1011CL-F(E) | Mouse Anti-CD274 Recombinant Antibody; Fab Fragment (TAB-1011CL-F(E)) | ELISA | Mouse Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-0263CL-F(E) | Human Anti-CD274 Recombinant Antibody; Fab Fragment (TAB-0263CL-F(E)) | ELISA, WB, SPR, FuncS | Humanized Fab |
TAB-0264CL-F(E) | Human Anti-CD274 Recombinant Antibody; Fab Fragment (TAB-0264CL-F(E)) | ELISA, WB, SPR, Inhib, FuncS | Humanized Fab |
TAB-0265CL-F(E) | Human Anti-CD274 Recombinant Antibody; Fab Fragment (TAB-0265CL-F(E)) | ELISA, WB, SPR, FuncS | Humanized Fab |
TAB-0266CL-F(E) | Human Anti-CD274 Recombinant Antibody; Fab Fragment (TAB-0266CL-F(E)) | ELISA, WB, SPR, FuncS | Humanized Fab |
VS3-WK1521 | Human Anti-CD274 Recombinant Antibody (clone RG7446) | ELISA, FC | Humanized IgG1 |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-0998CL-F(E) | Anti-Human CD274 Recombinant Antibody Fab Fragment (BII61-62) | ELISA | Human antibody |
TAB-0999CL-F(E) | Anti-Human CD274 Recombinant Antibody Fab Fragment (B50-6) | ELISA | Human antibody |
TAB-1000CL-F(E) | Human Anti-CD274 Recombinant Antibody; Fab Fragment (TAB-1000CL-F(E)) | ELISA | Human Fab |
TAB-1001CL-F(E) | Human Anti-CD274 Recombinant Antibody; Fab Fragment (TAB-1001CL-F(E)) | FC | Human Fab |
TAB-417CQ | Anti-Human CD274 Recombinant Antibody (TAB-417CQ) | ELISA, IHC, FC, IP, IF, Inhib | IgG1, κ |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-324CQ | Mouse Anti-CD274 Recombinant Antibody (clone 29E.2A3.C6) | IHC-P, FC, Neut, ICC | Mouse IgG2b, κ |
NEUT-325CQ | Human Anti-CD274 Recombinant Antibody (clone CBLS-206) | Neut | Human IgG1, κ |
NEUT-326CQ | Human Anti-CD274 Recombinant Antibody (clone CBLS-207) | ELISA, Neut | Human IgG1, κ |
NEUT-327CQ | Mouse Anti-CD274 Recombinant Antibody (clone MIH1) | FC, FuncS, Neut, IHC, IF | Mouse IgG1, κ |
NEUT-330CQ | Rat Anti-CD274 Recombinant Antibody (clone MIH5) | FC, FuncS, Neut, IHC-Fr, WB | Rat IgG2a, λ |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-328CQ | Rat Anti-CD274 Recombinant Antibody (VMC171) | Block, FC | Rat IgG2 |
NEUT-329CQ | Rat Anti-CD274 Recombinant Antibody (clone 10F.9G2) | FC, IF, Block | Rat IgG2b, κ |
NEUT-331CQ | Mouse Anti-CD274 Recombinant Antibody (clone alphaPD-L1) | ELISA, Block | Mouse IgG1, λ |
NEUT-332CQ | Rabbit Anti-CD274 Recombinant Antibody (clone CBL1009) | Block | Rabbit IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-0548 | Hi-Affi™ Rabbit Anti-CD274 Recombinant Antibody (clone DS548AB) | ELISA | Rabbit IgG |
MOR-4049 | Hi-Affi™ Rabbit Anti-CD274 Recombinant Antibody (clone SI116DS) | ELISA | Rabbit IgG |
MOR-4050 | Hi-Affi™ Rabbit Anti-CD274 Recombinant Antibody (clone SI117DS) | ICC, IF, FC | Rabbit IgG |
MOR-4051 | Hi-Affi™ Rabbit Anti-CD274 Recombinant Antibody (clone SI118DS) | FC | Rabbit IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-N0408-YC-VHH | Recombinant Humanized Anti-CD274 Single Domain Antibody (HPAB-N0408-YC-VHH) | ELISA, FC, BL | Human VHH |
HPAB-N0307-YC-VHH | Recombinant Humanized Anti-CD274 Single Domain Antibody (HPAB-N0307-YC-VHH) | ELISA, FC, BL | Humanized VHH |
NBD-0065-YJ-VHH | Camelid Anti-CD274 Recombinant Single Domain Antibody (NBD-0065-YJ-VHH) | ELISA | Camelid VHH |
NBD-0066-YJ-VHH | Camelid Anti-CD274 Recombinant Single Domain Antibody (NBD-0066-YJ-VHH) | ELISA, Inihb | Camelid VHH |
NBD-0067-YJ-VHH | Camelid Anti-CD274 Recombinant Single Domain Antibody (NBD-0067-YJ-VHH) | ELISA, FC | Camelid VHH |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0400LY | Human Anti-PDCD1 Recombinant Antibody (HPAB-0400LY) | ELISA, RIA, WB | Human IgG1 |
HPAB-0401LY | Human Anti-PDCD1 Recombinant Antibody (HPAB-0401LY) | ELISA, RIA, WB | Human IgG1 |
HPAB-0402LY | Human Anti-PDCD1 Recombinant Antibody (HPAB-0402LY) | ELISA, RIA, WB | Human IgG1 |
HPAB-0403LY | Human Anti-PDCD1 Recombinant Antibody (HPAB-0403LY) | ELISA, RIA, WB | Human IgG1 |
HPAB-0404LY | Human Anti-CD274 Recombinant Antibody (HPAB-0404LY) | ELISA, RIA, WB | Human IgG1 |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0561LY-S(P) | Human Anti-CD274 Recombinant Antibody; scFv Fragment (HPAB-0561LY-S(P)) | ELISA, Block | Chimeric scfv |
HPAB-0562LY-S(P) | Human Anti-CD274 Recombinant Antibody; scFv Fragment (HPAB-0562LY-S(P)) | ELISA, Block | Chimeric scfv |
HPAB-0563LY-S(P) | Human Anti-CD274 Recombinant Antibody; scFv Fragment (HPAB-0563LY-S(P)) | ELISA, Block | Chimeric scfv |
HPAB-0564LY-S(P) | Human Anti-CD274 Recombinant Antibody; scFv Fragment (HPAB-0564LY-S(P)) | ELISA, Block | Chimeric scfv |
HPAB-0565LY-S(P) | Human Anti-CD274 Recombinant Antibody; scFv Fragment (HPAB-0565LY-S(P)) | ELISA, Block | Chimeric scfv |
CAT | Product Name | Application | Type |
---|---|---|---|
AFC-TAB-417CQ | Afuco™ Anti-CD274 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-417CQ) | ELISA, IHC, FC, IP, IF, Inhib | ADCC enhanced antibody |
AFC-TAB-418CQ | Afuco™ Anti-CD274 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-418CQ) | ELISA, IHC, FC, IP, IF, BL | ADCC enhanced antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
VS-0924-YC110 | Mouse Anti-CD274 Recombinant Antibody Hexamer (VS-0924-YC110), CDC Enhanced | ELISA, WB, SPR, ADCC, CDC | Antibody hexamer |
VS-0924-YC111 | Human Anti-CD274 Recombinant Antibody Hexamer (VS-0924-YC111), CDC Enhanced | ELISA, WB, SPR, ADCC, CDC, Inhib | Antibody hexamer |
CAT | Product Name | Application | Type |
---|---|---|---|
VS-1024-XY375 | Mouse Anti-NHP CD274 Recombinant Antibody (clone 29E.2A3) | FC | Mouse IgG2b, kappa |
CAT | Product Name | Application | Type |
---|---|---|---|
VS-0225-XY32 | CytoStream™ Mouse Anti-CD274 Recombinant Antibody (clone 29E.2A3) | FC | Mouse IgG2b, kappa |
CAT | Product Name | Application | Type |
---|---|---|---|
VS-0325-FY65 | Human Anti-CD274 (clone MI4736) scFv-Fc Chimera | ELISA, Inhib | Human IgG1, scFv-Fc |
CAT | Product Name | Application | Type |
---|---|---|---|
VS-0425-YC608 | Recombinant Anti-CD274 Vesicular Antibody, EV Displayed (VS-0425-YC608) | Block, ELISA, FC, Cell-uptake |
CAT | Product Name | Application | Type |
---|---|---|---|
VS-0525-XY1152 | Anti-CD274 Immunohistochemistry Kit | IHC | |
VS-0525-XY1153 | Anti-Mouse CD274 Immunohistochemistry Kit | IHC | |
VS-0525-XY1154 | Anti-Human CD274 Immunohistochemistry Kit | IHC |
CAT | Product Name | Application | Type |
---|---|---|---|
VS-0525-YC202 | Recombinant Anti-CD274 Biparatopic Antibody, Tandem scFv | ELISA, IHC, FC, IP, IF | Tandem scFv |
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