Anti-PD-L1 Antibody-Cytokine Fusion Protein, IgG (3A7)-XCL2
CAT#: ACFP-CQ5416
This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-PD-L1 IgG to XCL2. It was expressed in CHO and purified with affinity chromatography. The immunocytokine retains the ability to bind the PD-L1 as well as the biological activity of XCL2.
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/3528/1899_B9_6_cr5ba2049576272_selected.jpg
Subcellular Location and Protein Expression
Figure 2 IF staining of human cell line BJ
Immunofluorescent staining of human cell line BJ shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/3528/1936_G3_3_blue_red_green.jpg
Subcellular Location and Protein Expression
Figure 3 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/3528/1953_G5_3_blue_red_green.jpg
Normal Tissue
Figure 4 Colon
Peripheral nerve/ganglion
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/76385/169546_A_9_3.jpg
Normal Tissue
Figure 5 Placenta
Cytotrophoblasts
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Syncytiotrophoblasts - cell body
Staining:Medium
Intensity: Moderate
Quantity:>75%
Syncytiotrophoblasts - microvilli
Staining:High
Intensity: Strong
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/76385/169546_A_1_7.jpg
RNA Expression
Figure 6 RNA cell line category: Cell line enhanced (HDLM-2, HHSteC, U-251 MG)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000120217-CD274
❮
❯
Specifications
- Target
- PD-L1
- Molecule Class
- IgG-XCL2
- Species Reactivity
- Human
- Expression Host
- CHO
- Clone
- 3A7
- Cytokine 1
- XCL2
- Cytokines 1 Description
- XCL2 (X-C Motif Chemokine Ligand 2) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include chemokine activity. An important paralog of this gene is XCL1.
- Cytokine 1 Species
- Human
- Applications
- This product can be used therapeutically to deliver biologically active ligands to a desired tissue.
Target
- Introduction
- This gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation.
- Alternative Names
- CD274; PD-L1; PDCD1L1; B7-H; Programmed Death Ligand 1; Programmed Cell Death 1 Ligand 1; PDCD1LG1; B7H1
- Gene ID
- 29126
- UniProt ID
- Q9NZQ7
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Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "Clone 3A7"
- CAT
- Product Name
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| HPAB-N0408-YC-VHH | Recombinant Humanized Anti-CD274 Single Domain Antibody (HPAB-N0408-YC-VHH) | ELISA, FC, BL | Human VHH |
| NBD-0065-YJ-VHH | Camelid Anti-CD274 Recombinant Single Domain Antibody (NBD-0065-YJ-VHH) | ELISA | Camelid VHH |
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| CAT | Product Name | Application | Type |
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| TAB-0190CL | Anti-Human CD274 Recombinant Antibody (PD1-AB1) | FC, ELISA, FuncS | |
| TAB-0997CL | Anti-Human CD274 Recombinant Antibody (B60-55) | ELISA, FuncS, FC, PK | Human antibody |
| TAB-0190CL-F(E) | Anti-Human CD274 Recombinant Antibody Fab Fragment (PD1-AB1) | FC, ELISA, FuncS | |
| TAB-0997CL-F(E) | Anti-Human CD274 Recombinant Antibody Fab Fragment (B60-55) | ELISA | Human antibody |
| TAB-1002CL-F(E) | Mouse Anti-CD274 Recombinant Antibody (TAB-1002CL-F(E)); Fab Fragment | ELISA, FC | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0262CL | Mouse Anti-CD274 Recombinant Antibody (TAB-0262CL) | ELISA, WB, SPR, ADCC, CDC, FuncS | Mouse IgG |
| TAB-0992CL | Mouse Anti-CD274 Recombinant Antibody (TAB-0992CL) | Inhib, FC, SPR | Mouse IgG |
| TAB-0992CL-F(E) | Mouse Anti-CD274 Recombinant Antibody; Fab Fragment (TAB-0992CL-F(E)) | FC | Mouse Fab |
| TAB-0993CL-F(E) | Mouse Anti-CD274 Recombinant Antibody; Fab Fragment (TAB-0993CL-F(E)) | FC | Mouse Fab |
| TAB-0994CL-F(E) | Mouse Anti-CD274 Recombinant Antibody; Fab Fragment (TAB-0994CL-F(E)) | ELISA, FC | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0263CL | Human Anti-CD274 Recombinant Antibody (TAB-0263CL) | ELISA, WB, SPR, FuncS | Humanized IgG |
| TAB-0264CL | Human Anti-CD274 Recombinant Antibody (TAB-0264CL) | ELISA, WB, SPR, ADCC, CDC, FuncS, Inhib | Humanized IgG |
| TAB-0265CL | Human Anti-CD274 Recombinant Antibody (TAB-0265CL) | ELISA, WB, SPR, ADCC, CDC, FuncS | Humanized IgG |
| TAB-0996CL-F(E) | Human Anti-CD274 Recombinant Antibody; Fab Fragment (TAB-0996CL-F(E)) | ELISA, FC | Humanized Fab |
| VS3-WK1521 | Human Anti-CD274 Recombinant Antibody (clone RG7446) | ELISA, FC | Humanized IgG1 |
| CAT | Product Name | Application | Type |
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| TAB-0995CL | Human Anti-CD274 Recombinant Antibody (TAB-0995CL) | ELISA, FC | Chimeric (Mouse/Human) IgG1, κ |
| TAB-0995CL-S(P) | Human Anti-CD274 Recombinant Antibody; scFv Fragment (TAB-0995CL-S(P)) | ELISA, FC | Human scFv |
| TAB-0995CL-F(E) | Human Anti-CD274 Recombinant Antibody; Fab Fragment (TAB-0995CL-F(E)) | ELISA, FC | Chimeric (Mouse/Human) Fab |
| CAT | Product Name | Application | Type |
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| NEUT-324CQ | Mouse Anti-CD274 Recombinant Antibody (clone 29E.2A3.C6) | IHC-P, FC, Neut, ICC | Mouse IgG2b, κ |
| NEUT-325CQ | Human Anti-CD274 Recombinant Antibody (clone CBLS-206) | Neut | Human IgG1, κ |
| NEUT-326CQ | Human Anti-CD274 Recombinant Antibody (clone CBLS-207) | ELISA, Neut | Human IgG1, κ |
| NEUT-327CQ | Mouse Anti-CD274 Recombinant Antibody (clone MIH1) | FC, FuncS, Neut, IHC, IF | Mouse IgG1, κ |
| NEUT-330CQ | Rat Anti-CD274 Recombinant Antibody (clone MIH5) | FC, FuncS, Neut, IHC-Fr, WB | Rat IgG2a, λ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-328CQ | Rat Anti-CD274 Recombinant Antibody (VMC171) | Block, FC | Rat IgG2 |
| NEUT-329CQ | Rat Anti-CD274 Recombinant Antibody (clone 10F.9G2) | FC, IF, Block | Rat IgG2b, κ |
| NEUT-331CQ | Mouse Anti-CD274 Recombinant Antibody (clone alphaPD-L1) | ELISA, Block | Mouse IgG1, λ |
| NEUT-332CQ | Rabbit Anti-CD274 Recombinant Antibody (clone CBL1009) | Block | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0548 | Hi-Affi™ Rabbit Anti-CD274 Recombinant Antibody (clone DS548AB) | ELISA | Rabbit IgG |
| MOR-4049 | Hi-Affi™ Rabbit Anti-CD274 Recombinant Antibody (clone SI116DS) | ELISA | Rabbit IgG |
| MOR-4050 | Hi-Affi™ Rabbit Anti-CD274 Recombinant Antibody (clone SI117DS) | ICC, IF, FC | Rabbit IgG |
| MOR-4051 | Hi-Affi™ Rabbit Anti-CD274 Recombinant Antibody (clone SI118DS) | FC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-005LC | Rat Anti-CD274 Recombinant Antibody (clone CBLS-205) | FC, IHC | Rat IgG |
| MOB-070LC | Human Anti-CD274 Recombinant Antibody (MOB-070LC) | ELISA, WB, FC, FuncS | Humanized IgG4 |
| HPAB-N0326-YC | Human Anti-CD274 Recombinant Antibody (HPAB-N0326-YC) | ELISA, FuncS | Human IgG |
| HPAB-N0407-YC | Human Anti-CD274 Recombinant Antibody; VHH-Fc Fragment (HPAB-N0407-YC) | FuncS, ELISA, Block | Human VHH-Fc |
| HPAB-0528LY | Human Anti-CD274 Recombinant Antibody (clone 047HAb-1) | ELISA | Human IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0406LY-S(P) | Human Anti-CD274 Recombinant Antibody; scFv Fragment (HPAB-0406LY-S(P)) | ELISA, RIA, WB | Human scfv |
| HPAB-0407LY-S(P) | Human Anti-CD274 Recombinant Antibody; scFv Fragment (HPAB-0407LY-S(P)) | ELISA, RIA, WB | Human scfv |
| HPAB-0408LY-S(P) | Human Anti-CD274 Recombinant Antibody; scFv Fragment (HPAB-0408LY-S(P)) | ELISA, RIA, WB | Human scfv |
| HPAB-0409LY-S(P) | Human Anti-CD274 Recombinant Antibody; scFv Fragment (HPAB-0409LY-S(P)) | ELISA, RIA, WB | Human scfv |
| HPAB-0410LY-S(P) | Human Anti-CD274 Recombinant Antibody; scFv Fragment (HPAB-0410LY-S(P)) | ELISA, RIA, WB | Human scfv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0400LY-F(E) | Human Anti-PDCD1 Recombinant Antibody; Fab Fragment (HPAB-0400LY-F(E)) | ELISA, RIA, WB | Human Fab |
| HPAB-0401LY-F(E) | Human Anti-CD274 Recombinant Antibody; Fab Fragment (HPAB-0401LY-F(E)) | ELISA, RIA, WB | Human Fab |
| HPAB-0402LY-F(E) | Human Anti-CD274 Recombinant Antibody; Fab Fragment (HPAB-0402LY-F(E)) | ELISA, RIA, WB | Human Fab |
| HPAB-0403LY-F(E) | Human Anti-CD274 Recombinant Antibody; Fab Fragment (HPAB-0403LY-F(E)) | ELISA, RIA, WB | Human Fab |
| HPAB-0404LY-F(E) | Human Anti-CD274 Recombinant Antibody; Fab Fragment (HPAB-0404LY-F(E)) | ELISA, RIA, WB | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-417CQ | Afuco™ Anti-CD274 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-417CQ) | ELISA, IHC, FC, IP, IF, Inhib | ADCC enhanced antibody |
| AFC-TAB-418CQ | Afuco™ Anti-CD274 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-418CQ) | ELISA, IHC, FC, IP, IF, BL | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0924-YC110 | Mouse Anti-CD274 Recombinant Antibody Hexamer (VS-0924-YC110), CDC Enhanced | ELISA, WB, SPR, ADCC, CDC | Antibody hexamer |
| VS-0924-YC111 | Human Anti-CD274 Recombinant Antibody Hexamer (VS-0924-YC111), CDC Enhanced | ELISA, WB, SPR, ADCC, CDC, Inhib | Antibody hexamer |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1024-XY375 | Mouse Anti-NHP CD274 Recombinant Antibody (clone 29E.2A3) | FC | Mouse IgG2b, kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0225-XY32 | CytoStream™ Mouse Anti-CD274 Recombinant Antibody (clone 29E.2A3) | FC | Mouse IgG2b, kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-FY65 | Human Anti-CD274 (clone MI4736) scFv-Fc Chimera | ELISA, Inhib | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC608 | Recombinant Anti-CD274 Vesicular Antibody, EV Displayed (VS-0425-YC608) | Block, ELISA, FC, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY1152 | Anti-CD274 Immunohistochemistry Kit | IHC | |
| VS-0525-XY1153 | Anti-Mouse CD274 Immunohistochemistry Kit | IHC | |
| VS-0525-XY1154 | Anti-Human CD274 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-YC202 | Recombinant Anti-CD274 Biparatopic Antibody, Tandem scFv | ELISA, IHC, FC, IP, IF | Tandem scFv |
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