Anti-PD-L1 Antibody-Cytokine Fusion Protein, IgG (PD1-AB1)-TNFSF13
CAT#: ACFP-CQ5117
This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-PD-L1 IgG to TNFSF13. It was expressed in CHO and purified with affinity chromatography. The immunocytokine retains the ability to bind the PD-L1 as well as the biological activity of TNFSF13.
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/3528/1899_B9_6_cr5ba2049576272_selected.jpg
Subcellular Location and Protein Expression
Figure 2 IF staining of human cell line BJ
Immunofluorescent staining of human cell line BJ shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/3528/1936_G3_3_blue_red_green.jpg
Subcellular Location and Protein Expression
Figure 3 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/3528/1953_G5_3_blue_red_green.jpg
Normal Tissue
Figure 4 Colon
Peripheral nerve/ganglion
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/76385/169546_A_9_3.jpg
Normal Tissue
Figure 5 Placenta
Cytotrophoblasts
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Syncytiotrophoblasts - cell body
Staining:Medium
Intensity: Moderate
Quantity:>75%
Syncytiotrophoblasts - microvilli
Staining:High
Intensity: Strong
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/76385/169546_A_1_7.jpg
RNA Expression
Figure 6 RNA cell line category: Cell line enhanced (HDLM-2, HHSteC, U-251 MG)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000120217-CD274
❮
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Specifications
- Target
- PD-L1
- Molecule Class
- IgG-TNFSF13
- Species Reactivity
- Human
- Expression Host
- CHO
- Clone
- PD1-AB1
- Cytokine 1
- TNFSF13
- Cytokines 1 Description
- The protein encoded by this gene is a member of the tumor necrosis factor (TNF) ligand family. This protein is a ligand for TNFRSF17/BCMA, a member of the TNF receptor family. This protein and its receptor are both found to be important for B cell development. In vitro experiments suggested that this protein may be able to induce apoptosis through its interaction with other TNF receptor family proteins such as TNFRSF6/FAS and TNFRSF14/HVEM. Alternative splicing results in multiple transcript variants. Some transcripts that skip the last exon of the upstream gene (TNFSF12) and continue into the second exon of this gene have been identified; such read-through transcripts are contained in GeneID 407977, TNFSF12-TNFSF13.
- Cytokine 1 Species
- Human
- Applications
- This product can be used therapeutically to deliver biologically active ligands to a desired tissue.
Target
- Introduction
- This gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation.
- Alternative Names
- CD274; PD-L1; PDCD1L1; B7-H; Programmed Death Ligand 1; Programmed Cell Death 1 Ligand 1; PDCD1LG1; B7H1
- Gene ID
- 29126
- UniProt ID
- Q9NZQ7
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Datasheet
MSDS
COA
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- CAT
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| PFBL-298 | Human Anti-CD274 Recombinant Antibody (clone CBLC-006); Fab Fragment | WB, ELISA, FuncS | Human Fab |
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| TAB-0995CL | Human Anti-CD274 Recombinant Antibody (TAB-0995CL) | ELISA, FC | Chimeric (Mouse/Human) IgG1, κ |
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| TAB-0262CL-S(P) | Mouse Anti-CD274 Recombinant Antibody; scFv Fragment (TAB-0262CL-S(P)) | ELISA, WB, SPR, FuncS | Mouse scFv |
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| TAB-0263CL-S(P) | Human Anti-CD274 Recombinant Antibody; scFv Fragment (TAB-0263CL-S(P)) | ELISA, WB, SPR, FuncS | Humanized scFv |
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| TAB-0266CL-S(P) | Human Anti-CD274 Recombinant Antibody; scFv Fragment (TAB-0266CL-S(P)) | ELISA, WB, SPR, FuncS | Humanized scFv |
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| TAB-1003CL-F(E) | Human Anti-CD274 Recombinant Antibody; Fab Fragment (TAB-1003CL-F(E)) | FC, ELISA | Human Fab |
| TAB-1004CL-F(E) | Human Anti-CD274 Recombinant Antibody; Fab Fragment (TAB-1004CL-F(E)) | FC | Human Fab |
| TAB-1005CL-F(E) | Human Anti-CD274 Recombinant Antibody; Fab Fragment (TAB-1005CL-F(E)) | FC | Human Fab |
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| TAB-1007CL-F(E) | Human Anti-CD274 Recombinant Antibody; Fab Fragment (TAB-1007CL-F(E)) | FC | Human Fab |
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| NEUT-324CQ | Mouse Anti-CD274 Recombinant Antibody (clone 29E.2A3.C6) | IHC-P, FC, Neut, ICC | Mouse IgG2b, κ |
| NEUT-325CQ | Human Anti-CD274 Recombinant Antibody (clone CBLS-206) | Neut | Human IgG1, κ |
| NEUT-326CQ | Human Anti-CD274 Recombinant Antibody (clone CBLS-207) | ELISA, Neut | Human IgG1, κ |
| NEUT-327CQ | Mouse Anti-CD274 Recombinant Antibody (clone MIH1) | FC, FuncS, Neut, IHC, IF | Mouse IgG1, κ |
| NEUT-330CQ | Rat Anti-CD274 Recombinant Antibody (clone MIH5) | FC, FuncS, Neut, IHC-Fr, WB | Rat IgG2a, λ |
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| NEUT-328CQ | Rat Anti-CD274 Recombinant Antibody (VMC171) | Block, FC | Rat IgG2 |
| NEUT-329CQ | Rat Anti-CD274 Recombinant Antibody (clone 10F.9G2) | FC, IF, Block | Rat IgG2b, κ |
| NEUT-331CQ | Mouse Anti-CD274 Recombinant Antibody (clone alphaPD-L1) | ELISA, Block | Mouse IgG1, λ |
| NEUT-332CQ | Rabbit Anti-CD274 Recombinant Antibody (clone CBL1009) | Block | Rabbit IgG |
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| MOR-0548 | Hi-Affi™ Rabbit Anti-CD274 Recombinant Antibody (clone DS548AB) | ELISA | Rabbit IgG |
| MOR-4049 | Hi-Affi™ Rabbit Anti-CD274 Recombinant Antibody (clone SI116DS) | ELISA | Rabbit IgG |
| MOR-4050 | Hi-Affi™ Rabbit Anti-CD274 Recombinant Antibody (clone SI117DS) | ICC, IF, FC | Rabbit IgG |
| MOR-4051 | Hi-Affi™ Rabbit Anti-CD274 Recombinant Antibody (clone SI118DS) | FC | Rabbit IgG |
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| HPAB-0193-YC | Human Anti-CD274 Recombinant Antibody (HPAB-0193-YC) | ELISA | Humanized IgG4, κ |
| HPAB-0194-YC | Mouse Anti-CD274 Recombinant Antibody (HPAB-0194-YC) | ELISA | Mouse IgG |
| HPAB-0195-YC | Human Anti-CD274 Recombinant Antibody (HPAB-0195-YC) | SPR | Humanized IgG |
| MOB-005LC | Rat Anti-CD274 Recombinant Antibody (clone CBLS-205) | FC, IHC | Rat IgG |
| MOB-070LC | Human Anti-CD274 Recombinant Antibody (MOB-070LC) | ELISA, WB, FC, FuncS | Humanized IgG4 |
| CAT | Product Name | Application | Type |
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| HPAB-M0455-YC-S(P) | Mouse Anti-CD274 Recombinant Antibody; scFv Fragment (HPAB-M0455-YC-S(P)) | ELISA | Mouse scFv |
| HPAB-M0456-YC-S(P) | Human Anti-CD274 Recombinant Antibody; scFv Fragment (HPAB-M0456-YC-S(P)) | ELISA, FC | Human scFv |
| HPAB-M0457-YC-S(P) | Human Anti-CD274 Recombinant Antibody; scFv Fragment (HPAB-M0457-YC-S(P)) | ELISA, FC, Block, FuncS | Human scFv |
| HPAB-M0458-YC-S(P) | Human Anti-CD274 Recombinant Antibody; scFv Fragment (HPAB-M0458-YC-S(P)) | ELISA, FC | Human scFv |
| HPAB-M0459-YC-S(P) | Human Anti-CD274 Recombinant Antibody; scFv Fragment (HPAB-M0459-YC-S(P)) | ELISA, FC | Human scFv |
| CAT | Product Name | Application | Type |
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| AFC-TAB-417CQ | Afuco™ Anti-CD274 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-417CQ) | ELISA, IHC, FC, IP, IF, Inhib | ADCC enhanced antibody |
| AFC-TAB-418CQ | Afuco™ Anti-CD274 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-418CQ) | ELISA, IHC, FC, IP, IF, BL | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
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| VS-0924-YC110 | Mouse Anti-CD274 Recombinant Antibody Hexamer (VS-0924-YC110), CDC Enhanced | ELISA, WB, SPR, ADCC, CDC | Antibody hexamer |
| VS-0924-YC111 | Human Anti-CD274 Recombinant Antibody Hexamer (VS-0924-YC111), CDC Enhanced | ELISA, WB, SPR, ADCC, CDC, Inhib | Antibody hexamer |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1024-XY375 | Mouse Anti-NHP CD274 Recombinant Antibody (clone 29E.2A3) | FC | Mouse IgG2b, kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0225-XY32 | CytoStream™ Mouse Anti-CD274 Recombinant Antibody (clone 29E.2A3) | FC | Mouse IgG2b, kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-FY65 | Human Anti-CD274 (clone MI4736) scFv-Fc Chimera | ELISA, Inhib | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC608 | Recombinant Anti-CD274 Vesicular Antibody, EV Displayed (VS-0425-YC608) | Block, ELISA, FC, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY1152 | Anti-CD274 Immunohistochemistry Kit | IHC | |
| VS-0525-XY1153 | Anti-Mouse CD274 Immunohistochemistry Kit | IHC | |
| VS-0525-XY1154 | Anti-Human CD274 Immunohistochemistry Kit | IHC |
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| VS-0525-YC202 | Recombinant Anti-CD274 Biparatopic Antibody, Tandem scFv | ELISA, IHC, FC, IP, IF | Tandem scFv |
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