Anti-CD33 (h2H12)-vc-PABC-MMAE ADC (CAT#: ADC-063LCT)

• Antibody Overview
• Humanized Murine CD33 Antibody (clone h2H12)

• Clone
• h2H12

• Linker
• VC-PABC (valine-citrulline-p-aminobenzoyloxycarbonyl)

• Linker Class/Description
• Peptide linkers, belonging to Enzymatically cleavable linkers, combine greater systemic stability with rapid enzymatic release of the drug in the target cell. The scission of peptidic bonds relies on lysosomal proteolytic enzymes, which have very low activities in blood due to endogenous inhibitors and the unfavorably high pH value of blood.

• Drug
• MMAE (Monomethyl auristatin E)

• Drug Class/Description
• Auristatins are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.

• Introduction
• CD33 or Siglec-3 is a transmembrane receptor expressed on cells of myeloid lineage. It is usually considered myeloid-specific, but it can also be found on some lymphoid cells. It binds sialic acids, therefore is a member of the SIGLEC family of lectins.

• Alternative Names
• CD33; CD33 molecule; p67; SIGLEC3; SIGLEC-3; myeloid cell surface antigen CD33; gp67; CD33 antigen (gp67); sialic acid binding Ig-like lectin 3; sialic acid-binding Ig-like lectin 3;

• Gene ID
• 945

• UniProt ID
• P20138

• ADC-093CL
• Anti-CD33 (clone h2H12) ADC

• ADC-146CL
• Anti-CD33 (clone h2H12)-mc-MMAF ADC

• ADC-062LCT
• Anti-CD33 (h2H12)-mc-vc-PBD ADC

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