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Anti-CD33 (clone hP67.6)-calicheamicin ADC (CAT#: ADC-143CL)

This ADC product is composed of an anti-CD33 antibody (clone hP67.6) conjugated via linker to calicheamicin(hP67.6-calicheamicin). It has demonstrated a response in CD33-expressing cancers treatment.


Specific Inquiry
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line PC-3
Figure 1 IF staining of human cell line PC-3
(Immunofluorescent staining of human cell line PC-3 shows localization to nucleoplasm & plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/64807/1186_A4_3_selected.jpg
Figure 2 IHC staining of human lymph node
Figure 2 IHC staining of human lymph node
(Immunohistochemical staining of human lymph node shows membranous and cytoplasmic positivity in germinal center cells and non-germinal center cells.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/35832/113039_A_9_8_selected.jpg
Figure 3 IHC staining of human tonsil
Figure 3 IHC staining of human tonsil
(Immunohistochemical staining of human tonsil shows cytoplasmic positivity in germinal center cells and non-germinal center cells.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/11442/26430_A_6_8_selected.jpg
Figure 4 IF staining of human cell line RH-30
Figure 4 IF staining of human cell line RH-30
(Immunofluorescent staining of human cell line RH-30 shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/64807/1413_G6_1_red_green.jpg
Figure 5 IF staining of human cell line U-2 OS
Figure 5 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/64807/1200_A4_2_red_green.jpg
Normal Tissue
Figure 6 Kidney
Figure 6 Kidney
(Cells in tubules
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/79996/170702_A_9_5.jpg
Figure 7 Lymph node
Figure 7 Lymph node
(Non-germinal center cells
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/79996/170702_A_9_8.jpg
Figure 8 Spleen
Figure 8 Spleen
(Cells in red pulp
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/79996/170702_B_8_4.jpg
RNA Expression
Figure 9 RNA cell line category: Cell line enhanced (HEL, HL-60, HMC-1, NB-4, RPMI-8226, THP-1, U-937)
Figure 9 RNA cell line category: Cell line enhanced (HEL, HL-60, HMC-1, NB-4, RPMI-8226, THP-1, U-937)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000105383-CD33

Specifications

  • Antibody Overview
  • Anti-CD33 Antibody hP67.6
  • Clone
  • hP67.6
  • Drug
  • calicheamicin
  • Drug Class/Description
  • Class: Calicheamicin
    Description: Calicheamicin, produced by prokaryotic microorganisms, are a group of DNA cleaving agents with similar structure that binds in the minor grove of DNA in a relatively sequence-specific manner.

Target

  • Introduction
  • CD33 or Siglec-3 is a transmembrane receptor expressed on cells of myeloid lineage. It is usually considered myeloid-specific, but it can also be found on some lymphoid cells. It binds sialic acids, therefore is a member of the SIGLEC family of lectins.
  • Alternative Names
  • CD33; CD33 molecule; p67; SIGLEC3; SIGLEC-3; myeloid cell surface antigen CD33; gp67; CD33 antigen (gp67); sialic acid binding Ig-like lectin 3; sialic acid-binding Ig-like lectin 3;

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Single-domain Antibody

CAT Product Name Application Type
NAB-321-sdAb Recombinant Anti-human CD33 VHH Single Domain Antibody WB, IP, ChiP, Neut, ELISA Llama VHH

Humanized Antibody

CAT Product Name Application Type
TAB-013 Humanized Anti-CD33 Recombinant Antibody (clone Gemtuzumab) IF, IP, Neut, FuncS, ELISA, FC, WB Humanized (from mouse) IgG4, κ
TAB-H37 Anti-Human CD33 Recombinant Antibody (Gemtuzumab Ozogamicin) ELISA, FC, IP, FuncS, IF, Neut, IHC IgG
TAB-756 Anti-CD33 Recombinant Antibody (Lintuzumab) IF, IP, Neut, FuncS, ELISA, FC, ICC IgG1 - kappa
VS3-WK1523 Human Anti-CD33 Recombinant Antibody (clone CDP-771) FC Humanized IgG4

Immunotoxin

CAT Product Name Application Type
AGTO-G008E Anti-CD33 immunotoxin (scFv)-PE Cytotoxicity assay, Function study
AGTO-G008G Anti-CD33 immunotoxin (scFv)-Gel Cytotoxicity assay, Function study
AGTO-L050E anti-CD33 immunotoxin M195 (IgG)-PE Cytotoxicity assay, Functional assay
AGTO-L050G anti-CD33 immunotoxin M195 (IgG)-Gel Cytotoxicity assay, Functional assay

Human Antibody

CAT Product Name Application Type
TAB-123LC Anti-Human CD33 Recombinant Antibody FC Human antibody
TAB-123LC-S(P) Anti-Human CD33 Recombinant Antibody scFv Fragment FC Human antibody
TAB-146LC-S(P) Human Anti-CD33 Recombinant Antibody; scFv Fragment (TAB-146LC-S(P)) ELISA Human scFv
TAB-123LC-F(E) Anti-Human CD33 Recombinant Antibody Fab Fragment FC Human antibody
TAB-146LC-F(E) Human Anti-CD33 Recombinant Antibody; Fab Fragment (TAB-146LC-F(E)) ELISA Human Fab

Mouse Antibody

CAT Product Name Application Type
TAB-133LC-F(E) Mouse Anti-CD33 Recombinant Antibody; Fab Fragment (TAB-133LC-F(E)) ELISA, FC Mouse Fab
TAB-134LC-F(E) Mouse Anti-CD33 Recombinant Antibody; Fab Fragment (TAB-134LC-F(E)) ELISA, FC Mouse Fab
TAB-135LC-F(E) Mouse Anti-CD33 Recombinant Antibody; Fab Fragment (TAB-135LC-F(E)) ELISA, FC Mouse Fab
TAB-136LC-F(E) Mouse Anti-CD33 Recombinant Antibody; Fab Fragment (TAB-136LC-F(E)) ELISA, FC Mouse Fab
TAB-137LC-F(E) Mouse Anti-CD33 Recombinant Antibody; Fab Fragment (TAB-137LC-F(E)) ELISA, FC Mouse Fab

Fab Glycosylation

CAT Product Name Application Type
Gly-013LC Recombinant Anti-Human CD33 Antibody (Fab glycosylation) ELISA Humanized antibody

Blocking Antibody

CAT Product Name Application Type
NEUT-341CQ Mouse Anti-CD33 Recombinant Antibody (clone WM53) FC, IHC-Fr, ICC, IP, WB, Block Mouse IgG1, κ

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-0553 Hi-Affi™ Rabbit Anti-CD33 Recombinant Antibody (clone DS553AB) WB, ICC, IP Rabbit IgG

Chimeric Antibody

CAT Product Name Application Type
TAB-471CQ Anti-Human CD33 Recombinant Antibody (Vadastuximab) ELISA, IHC, FC, IP, IF, FuncS IgG1, κ

MHC Tetramer for Cancer

CAT Product Name Application Type
MHC-LC2064 PE-A*02:01/Human CD33 (AIISGDSPV) MHC Tetramer FCM
MHC-CN0509 PE-A*02:01/Human CD33 (YLISGDSPV) MHC Tetramer FCM, IHC
MHC-CN0510 APC-A*02:01/Human CD33 (YLISGDSPV) MHC Tetramer FCM, IHC
MHC-CN0511 FITC-A*02:01/Human CD33 (YLISGDSPV) MHC Tetramer FCM, IHC
MHC-CN0512 A*02:01/Human CD33 (YLISGDSPV) MHC Tetramer FCM, IHC

scFv Fragment Antibody

CAT Product Name Application Type
FAMAB-0045CQ-S(P) Human Anti-CD33 Recombinant Antibody (clone huM195); scFv Fragment ELISA, FC Humanized scFv
HPAB-0741-FY-F(E) Mouse Anti-CD33 Recombinant Antibody (clone KM4074); scFv Fragment ELISA Mouse scFv
HPAB-0742-FY-F(E) Mouse Anti-CD33 Recombinant Antibody (clone KM4075); scFv Fragment ELISA Mouse scFv
HPAB-1103WJ-S(P) Mouse Anti-CD33 Recombinant Antibody; scFv Fragment (HPAB-1103WJ-S(P)) ELISA, WB Mouse scFv
HPAB-0532-YJ-S(P) Human Anti-CD33 Recombinant Antibody (clone ZJL101); scFv Fragment ELISA, Inhib Human scFv

Fab Fragment Antibody

CAT Product Name Application Type
HPAB-0307-FY-F(E) Human Anti-CD33 Recombinant Antibody (clone GO); Fab Fragment WB Humanized Fab
HPAB-1983LY-F(E) Human Anti-CD33 Recombinant Antibody; Fab Fragment (HPAB-1983LY-F(E)) FC Humanized Fab
HPAB-1984LY-F(E) Human Anti-CD33 Recombinant Antibody; Fab Fragment (HPAB-1984LY-F(E)) FC Humanized Fab
HPAB-1985LY-F(E) Human Anti-CD33 Recombinant Antibody; Fab Fragment (HPAB-1985LY-F(E)) FC Humanized Fab
HPAB-1986LY-F(E) Human Anti-CD33 Recombinant Antibody; Fab Fragment (HPAB-1986LY-F(E)) FC Humanized Fab

Recombinant Antibody

CAT Product Name Application Type
HPAB-M0471-YC Human Anti-CD33 Recombinant Antibody (HPAB-M0471-YC) FuncS Humanized IgG
HPAB-1993LY Human Anti-CD33 Recombinant Antibody (HPAB-1993LY) FC, ELISA Humanized IgG
HPAB-1994LY Human Anti-CD33 Recombinant Antibody (HPAB-1994LY) FC, ELISA Humanized IgG
HPAB-1995LY Human Anti-CD33 Recombinant Antibody (HPAB-1995LY) FC, ELISA Humanized IgG
HPAB-1996LY Human Anti-CD33 Recombinant Antibody (HPAB-1996LY) FC, ELISA Humanized IgG

ADCC Enhanced Antibody

CAT Product Name Application Type
AFC-TAB-471CQ Afuco™ Anti-CD33 ADCC Recombinant Antibody (Vadastuximab), ADCC Enhanced ELISA, IHC, FC, IP, IF, FuncS ADCC enhanced antibody
AFC-TAB-756 Afuco™ Anti-CD33 ADCC Recombinant Antibody (Lintuzumab), ADCC Enhanced IF, IP, Neut, FuncS, ELISA, FC ADCC enhanced antibody
AFC-TAB-013 Afuco™ Anti-CD33 ADCC Recombinant Antibody (Gemtuzumab), ADCC Enhanced IF, IP, Neut, FuncS, ELISA, FC ADCC enhanced antibody

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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